Stevia Side Effects: Nervous System & Psychological
Stevia is a type of natural sweetener derived from the leaves of a variety of plants that primarily grow throughout North and South America. Stevia is used as a sweetener and a sugar substitute because it has about 300 times the sweetness of sugar without the calories. However, stevia's safety and potential side effects have generated controversy. According to the Mayo Clinic, the U.S. Food and Drug Administration, FDA, has approved refined stevia for use as a sugar substitute; however, whole-leaf or crude extracts of stevia are not approved. Consult your physician before using a product containing stevia.
Central Nervous System Effects
Your central nervous system is composed of your brain and spinal cord and serves as the collection point for nerve impulses. Stevia contains beta-caryophyllene and caryophyllene oxide, compounds that may depress the activity of your central nervous system. Beta-caryophyllene epoxides may depress central nervous system activity by crossing the blood-brain barrier and binding to cellular receptors that regulate neurological impulses within your brain. More research is needed to determine the long-term effects of stevia on both brain and spinal cord.
- Your central nervous system is composed of your brain and spinal cord and serves as the collection point for nerve impulses.
- Stevia contains beta-caryophyllene and caryophyllene oxide, compounds that may depress the activity of your central nervous system.
Peripheral Nervous System Effects
Stevia Nutrition Information
Long-term stevia use may have adverse effects on your peripheral nervous system, which is comprised of sensory nerves that send and receive messages to and from your spinal cord and brain. Stevia may affect the transmission of nerve impulses to and from your central nervous system and may slow down nerve conduction velocity. Overdosing with stevia may lead to tingling or numbness in your hands and feet, similar to the feeling of neuropathy, as well as a temporary loss in motor control.
Stevia use may cause mild to severe psychological side effects, accordingn to The New Encyclopedia of Vitamins, Minerals, Supplements, and Herbs. Individuals suffering from psychosis, schizophrenia and other psychotic disorders may find a worsening of their symptoms as a result of stevia use. Stevia may interfere with the actions of anti-psychotic medications because they can compete for the same cellular receptors in the brain. Individuals taking anti-psychotic medications should consult with their physicians prior to using any products containing stevia.
- Stevia use may cause mild to severe psychological side effects, accordingn to The New Encyclopedia of Vitamins, Minerals, Supplements, and Herbs.
- Individuals suffering from psychosis, schizophrenia and other psychotic disorders may find a worsening of their symptoms as a result of stevia use.
Effects on Mood
Stevia & Testosterone
Stevia may affect hormone and neurotransmitter production in the brain. Neurotransmitters, such as dopamine and serotonin, are important in the natural regulation of mood and greatly influence thoughts of happiness and satisfaction. When these compounds are inhibited, you may have increased thoughts of depression and sadness. If you suffer from depression, anxiety, or nervousness, stevia may compound these symptoms because it slows the release of dopamine and serotonin.
- Stevia may affect hormone and neurotransmitter production in the brain.
- If you suffer from depression, anxiety, or nervousness, stevia may compound these symptoms because it slows the release of dopamine and serotonin.
Stevia Nutrition Information
Stevia & Testosterone
Stevia and Weight Loss
The Calories in Stevia
An Allergy to Stevia
Xylitol Vs. Stevia
Stevia Leaf Powder Vs. Leaf Extract
The Side Effects of Pure Via Stevia
Stevia & the Atkins Diet
Negative Side Effects of Royal Maca
- "The New Encyclopedia of Vitamins, Minerals, Supplements, and Herbs"; Nicola Reavley; 1999
- "Mayo Clinic"; Stevia: Can It Help With Weight Control?; Katherine Zeratsky, R.D., L.D; 2010
- "Human Anatomy and Physiology"; Elaine N. Marieb; 2004
- Toxicology Data Network; Beta-Caryophyllene Epoxide; 2002
- Giuffre L, Romaniuk R, Ciarlo E. Stevia, ka'a he'e, wild sweet herb from South America - An overview. Emir J. Food Agric. 2013;25(10):746-750. doi:10.9755/ejfa.v25i10.16405
- USDA. Stevia. Updated April 2019.
- Tandel KR. Sugar substitutes: Health controversy over perceived benefits. J Pharmacol Pharmacother. 2011;2(4):236–243. doi:10.4103/0976-500X.85936
- Regnat K, Mach RL, Mach-Aigner AR. Erythritol as sweetener-wherefrom and whereto?. Appl Microbiol Biotechnol. 2018;102(2):587–595. doi:10.1007/s00253-017-8654-1
- Samakkarnthani P, Payanundana M, Sathavarodom N, Siriwan C, Boonyavarakul A. Effect of stevia on glycemic and insulin responses in obese patients - A randomized, double-blind, placebo-controlled crossover study. Diabetes. 2018;67(Suppl 1). doi:10.2337/db18-790-P
- Dyrskog SE, Jeppesen PB, Chen J, Christensen LP, Hermansen K. The diterpene glycoside, rebaudioside A, does not improve glycemic control or affect blood pressure after eight weeks treatment in the Goto-Kakizaki rat. Rev Diabet Stud. 2005;2(2):84–91. doi:10.1900/RDS.2005.2.84
- Ashwell M. Stevia, Nature's zero-calorie sustainable sweetener: A new player in the fight against obesity. Nutr Today. 2015;50(3):129–134. doi:10.1097/NT.0000000000000094
- USDA. Has Stevia been approved by FDA to be used as a sweetener?. Updated March 2018.
- Nunes AP, Ferreira-Machado SC, Nunes RM, Dantas FJ, De Mattos JC, Caldeira-de-Araújo A. Analysis of genotoxic potentiality of stevioside by comet assay. Food Chem Toxicol. 2007;45(4):662–666. doi:10.1016/j.fct.2006.10.015
- American Academy of Allergy Asthma & Immunology. Allergic reactions to stevia, sucralose. Updated April 29, 2019.
- Kimata H. Anaphylaxis by stevioside in infants with atopic eczema. Allergy. 2007;62(5):565–566. doi:10.1111/j.1398-9995.2007.01317.x
Joe King began writing fitness and nutrition articles in 2001 for the "Journal of Hyperplasia Research" and Champion Nutrition. As a personal trainer, he has been helping clients reach their fitness goals for more than a decade. King holds a Bachelor of Science in kinesiology from California State University, Hayward, and a Master of Science in exercise physiology from California State University, East Bay.