Protonix is the name of a prescription medication that operates by preventing the stomach from producing acid 1. It is a drug that is classified as a proton pump inhibitor (abbreviated as PPI). It is commonly used for throat and stomach issues that are directly caused by acid, such as gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome. As with any type of medicine, there are some possible side effects that can occur as a result of taking Protonix 1.

Is This an Emergency?

If you are experiencing serious medical symptoms, seek emergency treatment immediately.

Common Side Effects

There are several relatively common side effects that are often linked to Protonix 1. In general, these side effects are not considered to be serious, as they tend to subside quickly on their own as the body adjusts to the medication. However, if they linger or get worse, medical attention might be necessary. These side effects include:

  • insomnia
  • abdominal ache
  • diarrhea
  • burping
  • gas
  • hyperglycemia
  • nausea
  • throwing up
  • skin rash

Less Common Side Effects

There are also some less common, but possible side effects of Protonix 1. These side effects include:

  • respiratory tract infection
  • coughing
  • constipation
  • chest ache
  • bronchitis
  • neck pain
  • back ache
  • sore throat
  • anxiety
  • joint pain
  • dizziness
  • feeling lightheaded
  • indigestion
  • high levels of fat in the blood
  • migraine headache
  • flu syndrome
  • rhinitis
  • urinary tract infection (UTI)
  • gastroenteritis
  • insufficient energy or strength

Rare Side Effects

There are also some highly rare side effects of Protonix 1.


Some of the Protonix side effects are extremely dangerous 1. The most dangerous side effects of the medication involve pancreas inflammation, damage to the eyes and serious allergic reactions. It is vital to get emergency medical attention if you have trouble with swallowing or breathing, or suddenly develop peeling and blistering of the skin (or any other unusual side effects).

Drug Interactions

Drug interactions can occur when more than one medication is taken at the same time. Drug interactions can result in unpleasant side effects, as well as decreased or increased effectiveness of one or all of the medicines that are involved. Some drugs that can result in interactions with Protonix include ketoconazole, ampicillin and warfarin 1. It is crucial to notify your doctor of all medications and nutritional supplements you might be taking when considering Protonix as an option 1.