If you’re taking omeprazole or another proton pump inhibitor to treat GERD or other stomach or esophagus problems, you may be at risk of iron deficiency 123. Research suggests a connection between omeprazole and anemia 1.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
If you have concerns about how long-term use of omeprazole may affect your health, talk to your doctor 1. The following information can give you some talking points for such a discussion.
Omeprazole is a proton pump inhibitor that decreases the amount of acid your stomach makes, helping treat issues such as acid reflux and ulcers. Long-term use of proton pump inhibitors does increase your risk of developing iron-deficient anemia. Talk to your doctor about the risks and benefits of the prescription medication.
Use of Omeprazole
Omeprazole can help heal acid damage to the stomach and esophagus caused by gastroesophageal reflux disease (GERD) and other stomach or esophagus problems associated with the amount of acid your stomach creates, explains MedlinePlus 1.
GERD occurs when the backward flow of acid from the stomach gurgles into your throat, causing heartburn, persistent cough, sensation of a lump in your throat and difficulty swallowing.
Omeprazole is available in prescription and nonprescription forms 1. The prescription form may be recommended to treat severe GERD and its complications. Nonprescription forms are available at your local drugstore to treat frequent heartburn, which is defined as occurring more than twice per week.
- Omeprazole can help heal acid damage to the stomach and esophagus caused by gastroesophageal reflux disease (GERD) and other stomach or esophagus problems associated with the amount of acid your stomach creates.
- Nonprescription forms are available at your local drugstore to treat frequent heartburn, which is defined as occurring more than twice per week.
Side Effects of Omeprazole
Vegetarian GERD Diet
You may experience issues such as gas, constipation, nausea and diarrhea while taking the medication. Vomiting and headaches can also occur. The listed side effects of omeprazole don’t mention effects on your iron levels or ability to absorb iron 1.
If you're on a prescription dose of omeprazole, consult with your physician if you experience the side effects regularly and they interfere with your quality of life 1. Take only the prescribed dose of omeprazole at the recommended times to minimize complications 1.
- You can eat a normal diet.
- If you're on a prescription dose of omeprazole, consult with your physician if you experience the side effects regularly and they interfere with your quality of life 1.
About the Mineral Iron
Iron is a micronutrient, a mineral you need in small doses for proper body function.
Iron helps you produce red blood cells and deliver oxygen to tissues and cells. It helps support optimal physical growth and development.
Iron is available in two forms: Heme and nonheme.
Heme forms are found in animal products, such as liver, beef and shellfish. Nonheme forms are available in plant foods such as legumes and spinach.
According to the National Institutes of Health, people in the United States usually get enough iron through a balanced diet 5. Some people, particularly menstruating women, those suffering from certain illnesses and people who follow a vegetarian diet, are at a risk of iron-deficient anemia.
Your cognitive abilities and immune system may also suffer.
- Iron is a micronutrient, a mineral you need in small doses for proper body function.
Omeprazole and Anemia
Causes of Microcytic Hypochromic Anemia
You may be concerned about use of omeprazole and your iron levels 1. Gastric acid produced in your stomach helps your body absorb nonheme iron from your diet, explains the National Institutes of Health 5. Proton pump inhibitors, such as omeprazole, reduce your production of stomach acid, having an impact on your ability to absorb iron 1.
Case studies show a connection between PPIs and iron-deficient anemia.
Doctors concluded his anemia was due to malabsorption of iron caused by reduced stomach acid. His anemia didn't result from taking in too little of the mineral or from undetected bleeding.
Another case study published in a March 2018 issue of Internal Medicine showed that a 52-year-old man who took omeprazole for 25 years developed iron-deficiency anemia due to lack of absorption of the mineral 16. This long-term use of the medication was the attributed cause of his condition.
Case studies aren’t often enough to prove a relationship, but a larger study of almost 3,000 cases published in the Journal of Internal Medicine in February 2019 confirmed that chronic use of proton pump inhibitors increases a person’s risk of iron deficiency anemia 236. The researchers recommend that physicians consider this association between omeprazole and iron absorption when prescribing the drug to patients 1.
People can’t correct the iron deficiency easily if they’re on omeprazole 1. The National Institutes of Health explains that people who have iron deficiency and who take proton pump inhibitors often have less than desirable responses to iron supplementation 35.
- You may be concerned about use of omeprazole and your iron levels 1.
- Case studies aren’t often enough to prove a relationship, but a larger study of almost 3,000 cases published in the Journal of Internal Medicine.
- People can’t correct the iron deficiency easily if they’re on omeprazole 1.
Natural Ways to Control GERD
Of course, if your GERD or other esophageal or stomach acid issues are severe, proton pump inhibitors may be essential.
Talk to your doctor about limiting your intake of these medications, especially if you're already at risk of iron deficiency. Also reconsider your personal treatment of mild symptoms of GERD. Think again if you always reach for a few doses of Prevacid (a type of proton pump inhibitor called lansoprazole) or Prilosec (omeprazole) whenever you suffer heartburn 1.
Lifestyle changes can go a long way in reducing symptoms of acid reflux. Cut back on your total fat intake by reducing ingredients such as butter, full-fat dairy, fatty meats and oils. Eating small, frequent meals, rather than three large meals, can also help with digestion and acid production.
Always eat when upright, rather than lying down, and finish your last meal or snack at least three hours prior to bedtime.
You may also raise the head of your bed with wooden blocks by about 6 to 8 inches. The Cleveland Clinic says that pillows don't work 7.
- Of course, if your GERD or other esophageal or stomach acid issues are severe, proton pump inhibitors may be essential.
- Read more: The Best Foods to Eat if You Have Acid Reflux Always eat when upright, rather than lying down, and finish your last meal or snack at least three hours prior to bedtime.
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What are the Long-Term Effects of Omeprazole?
Names of Iron Supplements
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Omeprazole and Vitamin B-12 Deficiency
- Medline Plus: "Omeprazole"
- Internal Medicine: "Iron Deficiency Anemia Due to the Long-term Use of a Proton Pump Inhibitor"
- Journal of Internal Medicine: "Use of Proton Pump Inhibitors and Risk of Iron Deficiency: A Population-based Case-control Study"
- Current Therapeutic Research, Clinical and Experimental: "A Case of Severe Iron Deficiency Anemia Associated With Long-Term Proton Pump Inhibitor Use"
- National Institutes of Health: "Iron"
- Medline Plus: "Iron Deficiency Anemia"
- Cleveland Clinic: "Lifestyle Guidelines for the Treatment of GERD"
- American Academy of Pediatrics Clinical Report. Diagnosis and Prevention of Iron Deficiency and Iron Deficiency Anemia in Infants and Young Children (0-3 Years of Age). Pediatrics 2010; 126: 1040-1050.
- Hoffman: Hematology: Basic Principles and Practice, 5th ed.
- Kliegman: Nelson Textbook of Pediatrics, 18th ed.
- NIH. Office of Dietary Supplements. Dietary Supplement Fact Sheet: Iron. Updated August 2007.
Andrea Cespedes is a professionally trained chef who has focused studies in nutrition. With more than 20 years of experience in the fitness industry, she coaches cycling and running and teaches Pilates and yoga. She is an American Council on Exercise-certified personal trainer, RYT-200 and has degrees from Princeton and Columbia University.