Medications That Will Test Positve for THC
The American Council for Drug Education reports marijuana, also known as THC for its active ingredient of delta-9-tetrahydrocannabinol, as the most commonly used illegal drug 3. To help increase productivity and fight the war on drugs, many employers, parents and schools routinely test for drugs through urine, blood or hair drug screens. These drug tests detect the metabolites of drugs--the substances produced when the body breaks down the drug. This allows for false-positive test results triggered by the metabolites of certain prescription and nonprescription medications, which occurs in approximately one to 2.5 percent of cases, according to the NetWellness Consumer Health Information 1.
Dronabinol
Dronabinol consists of the chemical delta-9-tetrahydrocannabinol, the active ingredient found in marijuana. Therefore, this medication produces a positive result when testing for THC. Doctors prescribe dronabinol to stimulate the appetite in patients with AIDS anorexia as well as to treat nausea and vomiting triggered by chemotherapy treatments. According to the Oregon State College of Pharmacy, doctors continue to perform additional studies testing the use of dronabinol in treating symptoms of multiple sclerosis, migraine and glaucoma.
- Dronabinol consists of the chemical delta-9-tetrahydrocannabinol, the active ingredient found in marijuana.
- According to the Oregon State College of Pharmacy, doctors continue to perform additional studies testing the use of dronabinol in treating symptoms of multiple sclerosis, migraine and glaucoma.
Ibuprofen
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Ibuprofen, classified as a nonsteroidal anti-inflammatory medication, effectively relieves pain and reduces swelling and stiffness. Both prescription and nonprescription medications contain ibuprofen, which often occurs in combinations with other drug such as in some cough and cold medications. In the past, ibuprofen proved to cause false-positive test results; however, the National Organization for the Reform of Marijuana Laws reports that this problem has been resolved 2.
Ketoprofen
Ketoprofen, similar to ibuprofen, relieves pain, swelling and stiffness. Often prescribed to treat rheumatoid arthritis--swelling of the joints--the chemical structure of ketoprofen resembles that of ibuprofen. This means the metabolites look similar and can cause the same interference with drug tests for THC.
Naproxen
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Naproxen, also classified as a nonsteroidal anti-inflammatory drug, treats inflammation, swelling, stiffness and pain in joints. Available in prescription and nonprescription strength, naproxen can trigger a false-positive result on a drug test, according to NetWellness Consumer Health Information 1.
Promethazine
Promethazine, a prescription medication, blocks the effects of histamine, a substance produced and released in the body during an immune response. Doctors prescribe promethazine for many types of conditions. It relieves the symptoms of allergies, including runny nose, watery eyes and skin reactions. Promethazine also works as an anti-emetic, controlling the symptoms of nausea and vomiting. Because promethazine causes drowsiness, doctors often use it before and after surgery to sedate patients. Medications containing promethazine may produce false-positive results in THC drug tests.
- Promethazine, a prescription medication, blocks the effects of histamine, a substance produced and released in the body during an immune response.
- Because promethazine causes drowsiness, doctors often use it before and after surgery to sedate patients.
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References
- NetWellness Consumer Health Information: Drug Testing
- National Organization for the Reform of Marijuana Laws: Drug Testing Tips
- American Council for Drug Education: Basic Facts About Marijuana
- U.S. National Library of Medicine. Compound summary: Promethazine. Updated February 15, 2020.
- Monczor F, Fernandez N. Current knowledge and perspectives on histamine H1 and H2 receptor pharmacology: Functional selectivity, receptor crosstalk, and repositioning of classic histaminergic ligands. Mol Pharmacol. 2016;90(5):640-8. doi:10.1124/mol.116.105981
- U.S. Food and Drug Administration. Promethazine hydrochloride injection, USP. Revised October 2009.
- Wilson MP, Pepper D, Currier GW, Holloman GH Jr, Feifel D. The psychopharmacology of agitation: consensus statement of the American Association for Emergency Psychiatry Project Beta Psychopharmacology Workgroup. West J Emerg Med. 2012;13(1):26-34. doi:10.5811/westjem.2011.9.6866
- Gelfand AA, Goadsby PJ. A neurologist's guide to acute migraine therapy in the emergency room. Neurohospitalist. 2012;2(2):51-9. doi:10.1177/1941874412439583
- Recto MT, Gabriel MT, Kulthanan K, et al. Selecting optimal second-generation antihistamines for allergic rhinitis and urticaria in Asia. Clin Mol Allergy. 2017;15:19. doi:10.1186/s12948-017-0074-3
- U.S. Food and Drug Administration. Phenergan (promethazine HCI) tablets and suppositories. Revised 2004.
- U.S. Food and Drug Administration. Promethazine HCl and codeine phosphate oral solution. Revised January 2017.
- U.S. Food and Drug Administration. Promethazine HCL plain oral solution. Revised May 2008.
- Cantisani C, Ricci S, Grieco T, et al. Topical promethazine side effects: our experience and review of the literature. Biomed Res Int. 2013;2013:151509. doi:10.1155/2013/151509
- Kar S, Krishnan A, Preetha K, Mohankar A. A review of antihistamines used during pregnancy. J Pharmacol Pharmacother. 2012;3(2):105-8. doi:10.4103/0976-500X.95503
- Bustos M, Venkataramanan R, Caritis S. Nausea and vomiting of pregnancy - What's new?. Auton Neurosci. 2017;202:62-72. doi:10.1016/j.autneu.2016.05.002
- American College of Obstetrics and Gynecology. ACOG practice bulletin no. 189: Nausea and vomiting of pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. doi:10.1097/AOG.0000000000002456
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Writer Bio
Stephanie Chandler is a freelance writer whose master's degree in biomedical science and over 15 years experience in the scientific and pharmaceutical professions provide her with the knowledge to contribute to health topics. Chandler has been writing for corporations and small businesses since 1991. In addition to writing scientific papers and procedures, her articles are published on Overstock.com and other websites.