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Do GABA Supplements Have Side Effects?

GABA, known more formally as gamma-aminobutyric acid, is a chemical in the brain responsible for sending nerve signals throughout your central nervous system. Treatment with GABA supplements are purported to help reduce high blood pressure as well as symptoms of stress, anxiety and insomnia. However, the effectiveness of GABA supplements has yet to be fully evaluated. Consult your medical provider about the safety of GABA supplements before initiating treatment.

Safety Issues

Treatment with GABA supplements is generally regarded as safe when used appropriately. However, more extensive clinical studies evaluating the safety of this supplement are necessary. If you experience any unusual health problems or side effects while taking GABA supplements, contact your doctor for further evaluation.

Medication Interactions

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To date, there are no known medication interactions associated with taking GABA supplements. Before taking this supplement, however, discuss all medications you're taking with your physician.


The safety and effectiveness of GABA supplements have not been evaluated during pregnancy or related side effects. For this reason, women who are pregnant or lactating should avoid taking GABA supplements. In addition, people with liver or kidney disease shouldn't take GABA supplements without first consulting a doctor.

Dosing Guidelines

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To reduce high blood pressure, health professionals with the University of Pittsburgh Medical Center recommend adults take 10 mg of GABA daily. Higher doses of GABA of up to 1,000 mg daily may be necessary to alleviate symptoms associated with insomnia or anxiety. For more personalized dosing recommendations, seek guidance from your medical provider.