Can You Take Dexedrine & Vitamins?

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The process of metabolizing an ingested medication is complex, leaving little room for error. Something as minor as taking a vitamin supplement with your Dexedrine can impact the way your body metabolizes the medication. Consult your doctor or pharmacist before adding any vitamins, supplements or medications to your regimen.

About Dexedrine

Dexedrine is the trade name for dextroamphetamine, a prescription medication used to treat attention deficit hyperactivity disorder and narcolepsy. This medication is a central nervous system stimulant. Typically, Dexedrine is prescribed to be administered once or twice per day in the early or mid-morning. It is generally not recommended that Dexedrine be taken in the afternoon because doing so could cause insomnia. Unlike many other medications, it is usually necessary to take Dexedrine only on days when you need its benefits.

Dexedrine and Vitamins

Most vitamins do not interact with Dexedrine. However, taking vitamin C or eating vitamin C-rich food within two hours of taking Dexedrine can inhibit your body's absorption of the medication and decrease its effectiveness. Some people do this by scheduling their Dexedrine as soon as they wake up and then eat breakfast and take their vitamins two hours later.

Sources of Vitamin C

Knowing which foods and vitamins are rich in vitamin C is the first step in avoiding mixing Dexedrine with vitamin C. Many over-the-counter supplements contain vitamin C, including many multivitamins and throat lozenges. Nearly all fruits and fruit juices are rich in vitamin C with citrus fruits and fruit juices containing the most vitamin C. Leafy green vegetables are also high in vitamin C.


Dexedrine can be taken with or without food, although some people find that Dexedrine causes stomach upset when administered on an empty stomach. Drink a glass of milk or eat a slice of toast when you take Dexedrine if you are prone to stomach upset. These foods are poor sources of vitamin C and are small enough to be consumed in the morning without ruining your appetite for breakfast yet dense enough to prevent gastrointestinal upset.