Vitamin E, which you might be ingesting with your meals or taking as a supplement, is an antioxidant, meaning it helps protect your cells from toxic environmental pollutants and the potentially damaging side effects of metabolism. Aspirin, which your health care provider might recommend to help you limit your risk for heart attacks or strokes, is categorized as a drug. For any supplement you take, you should check with your doctor about possible harmful interactions with drugs you might be taking, including aspirin.

Risks of Taking Vitamin E and Aspirin Together

According to, you need to talk to your physician about using supplemental vitamin E at doses greater than 400 units per day if you’re taking antiplatelet or anticoagulant medications, or if you are vitamin K deficient, because such a dose of vitamin E could increase your risk for bleeding. Low-dose aspirin is an antiplatelet drug, while warfarin, also known as Coumadin, is an anticoagulant.

Benefits of Combining Vitamin E and Aspirin

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Both low-dose aspirin and moderate amounts of vitamin E have benefits separately and only rarely cause problems if taken at the same time. One benefit of combining the two was reported in 2005 in the journal “Neuroscience.” In a study, researchers demonstrated that guinea pigs given aspirin and vitamin E as long as three days after high levels of noise exposure were able to mitigate their hearing loss and hair cell damage 3.

Vitamin E, Aspirin and Cardiovascular Disease

A study reported in the "American Journal of Clinical Nutrition" in 1995 found that participants who took both vitamin E and aspirin had fewer stroke-like incidents than participants who took aspirin alone 4. The organization does, however, continue to recommend daily low-dose aspirin use for those who are at risk of heart disease.

Vitamin E Basics

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Vitamin E comes in many forms but it’s only the alpha-tocopherol form that really benefits your health. The Office of Dietary Supplements, or ODS, lists 15 mg — or 22.4 IU — per day as the recommended dietary allowance for adults 5.

Aspirin Risks and Benefits

If you are at risk for heart disease or if already have had a heart attack, the AHA recommends talking to your doctor about taking daily doses of up to 325 mg of aspirin. Low-dose aspirin also might help prevent strokes by keeping the platelets in your blood from being too sticky, leading to clogging of your arteries.