Can You Take Zoloft & Chantix Together?

Although the antidepressant Zoloft and the smoking cessation medication Chantix have no known interactions with each other, many people are still concerned about the best way to go about taking these two medications at the same time. While there are certain things that should be kept in mind when taking these two medications together, it usually is not a problem if you follow a few simple steps.

Is This an Emergency?

If you are experiencing serious medical symptoms, seek emergency treatment immediately.

Talk to your doctor. Make sure you are aware of the potential risks and side effects involved with Zoloft and Chanitx. Provide a complete medical background so your doctor can advise you of any considerations that may be unique to your specific situation. Although both Chantix and Zoloft are taken once a day and can be taken with or without food, talk to your doctor about the advantages and disadvantages about taking the medications at the same time of day or at two different times.

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Take each medication according to its instructions. It can be easy when taking more than one medication to confuse one set of instructions with another, so keep each set of instructions easily accessible for reference and review each as necessary.

Monitor yourself for unusual side effects. Both medications can cause side effects, but many of these side effects are mild and will go away on their own as your body adjusts to the medication, according to 12. However, if you experience any side effect that is persistent, bothersome or seems to indicate a serious problem, contact your doctor to see what should be done.

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Watch for suicidal thoughts or expressions. Although both Chantix and Zoloft can cause suicidal thoughts or tendencies, according to, taking these medications together should not increase this risk any more than if you were taking either medication by itself 12. However, it is important that you remain vigilant about monitoring your thoughts and feelings to make sure these suicidal tendencies are not present.

Communicate on an ongoing basis with your doctor while on the medications. Your doctor may need to test your kidney function periodically while you are taking Chantix, reports, and she also may need to monitor your mood and behavior while on Zoloft to determine if your dosage needs to be changed 12. Therefore, it is important that you keep all scheduled doctor's appointments and frequently communicate with your doctor about how you are feeling.


Ask your family and friends to also monitor your mood and behavior and keep an eye out for signs of suicidal expressions. It can be very beneficial to have this objective viewpoint, especially if a medication is interfering with your normal judgment.


Report any thoughts of suicide to a doctor or mental health professional immediately.