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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- MayoClinic.com: Nutrition and Healthy Eating
- MayoClinic.com: Niacin (vitamin B3, nicotinic acid), Niacinamide
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
Side Effects of Niacin and Caffeine Together
Niacin is a B vitamin that you may get from food, or you can take it as a standalone supplement or part of a multivitamin. Green leafy plants and many vegetables such as beans, broccoli and poultry and fish contain niacin, MayoClinic.com reports 5. You can take it as a supplement to treat high cholesterol levels in your blood, as well as to treat high blood pressure. You may get caffeine, a natural stimulant substance, in teas, sodas and supplements among other substances, MayoClinic.com says. Caffeine and niacin have known side effects 3.
Dizziness
Both caffeine and niacin may cause dizziness, Drugs.com says 35. You may experience a heightened effect of this dizziness by taking them together. Your head may feel fuzzy and you may experience an uncommon sensation of motion, even if you're not moving. You may need to become still in a sitting or lying position. If this common side effect continues or feels severe, call your doctor. Dizziness as a side effect of niacin and caffeine most likely occurs during the first stage of your use of the substances but should fade without the aid of your doctor.
- Both caffeine and niacin may cause dizziness, Drugs.com says 3.
- If this common side effect continues or feels severe, call your doctor.
Nausea
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Caffeine and niacin both may induce problems in your stomach and produce nausea -- primarily when you first use them together. For example, if you already drink caffeinated soda, you may develop nausea when you start ingesting niacin as a supplement. Your stomach may feel queasy and your appetite may go away. If this feeling doesn't stop on its own, call your physician.
- Caffeine and niacin both may induce problems in your stomach and produce nausea -- primarily when you first use them together.
Diarrhea
You may get a bout of diarrhea when you start niacin as a supplement, RxList.com reports 45. You may need to have several bowel movements that appear watery, and you may feel cramps in your abdomen because of this intestinal disturbance. Caffeine doesn't produce this common side effect. Talk with your doctor if this side effect continues.
- You may get a bout of diarrhea when you start niacin as a supplement, RxList.com reports 4.
Flushing
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Your skin may flush or become warmer than normal and produce breakout sweating when you take niacin, RxList.com says 45. This non-serious and temporary side effect doesn't result from caffeine but relates to niacin use. Flushing should cease on its own.
Nervousness
Caffeine, a central nervous stimulant, may cause you to feel jittery and jumpy, Drugs.com says 5. It also may cause you to feel irritable and anxious -- but usually only when you start taking it into your body, or if you ingested too much. If this common side effect continues, consult your doctor.
Niacin and Caffeine Interactions
There are no known side effects of caffeine and niacin, Drugs.com says 35. However, interactions between the two may cause side effects not yet discovered through clinical trials. Before starting any new medication or supplement, consult your doctor and pharmacist.
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References
- Drugs.com: Drug Interactions Results
- MayoClinic.com: Nutrition and Healthy Eating
- Drugs.com: Niacin Side Effects
- RxList.com: Niaspan
- Drugs.com: Niacin
- National Institutes of Medicine Office of Dietary Supplements. Niacin Fact Sheet for Health Professionals. Updated June 3, 2020.
- MedlinePlus. Niacin. Updated June 4, 2020.
- Boden WE, Probstfield JL, Anderson T, et al. Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy. N Engl J Med. 2011;365(24):2255-2267. doi:10.1056/NEJMoa1107579
- Morris MC, Evans DA, Bienias JL, et al. Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline. J Neurol Neurosurg Psychiatry. 2004;75(8):1093-1099. doi:10.1136/jnnp.2003.025858
- Elam MB, Hunninghake DB, Davis KB, et al. Effect of Niacin on Lipid and Lipoprotein Levels and Glycemic Control in Patients With Diabetes and Peripheral Arterial Disease: The ADMIT Study: A Randomized Trial. JAMA. 2000;284(10):1263-1270. doi:10.1001/jama.284.10.1263
- Zhai G. Alteration of Metabolic Pathways in Osteoarthritis. Metabolites. 2019;9(1):11. doi:10.3390/metabo9010011
Writer Bio
Carole Anne Tomlinson is a registered nurse with experience in rehabilitation, nutrition, chemical dependency, diabetes and health problems related to the elderly. Tomlinson holds a Bachelor of Arts in criminal justice and is presently working on her master's degree in nursing. Her screenplays have been viewed by Merchant Ivory, Angela Lansbury and Steven King's associates.