Vitamin D and Its Effects on Eyesight
It has been estimated that the complex system that enables eyesight requires about 30 percent of a person’s oxygen intake and 25 percent of their nutritional intake. Thus, healthy eyesight depends on essential nutrients, such as vitamins. Vitamins A, C and E are antioxidants that have been well-established as preserving eyesight and promoting healthy eyes, but evidence suggests vitamin D is associated with reduced risks of macular degeneration.
Macular degeneration is a condition that leads to the loss of a person's central field of vision as a result of a degenerating macula, the small region within the retina where vision is sharpest. It is widely recognized as the leading cause of adult irreversible vision loss in developed countries. Macular degeneration doesn’t lead to complete blindness, as peripheral vision is unaffected. The National Eye Institute states about 9 million Americans over the age of 40 suffer from macular degeneration.
- Macular degeneration is a condition that leads to the loss of a person's central field of vision as a result of a degenerating macula, the small region within the retina where vision is sharpest.
- The National Eye Institute states about 9 million Americans over the age of 40 suffer from macular degeneration.
Vitamin D and Macular Degeneration
Foods to Help Prevent Cataracts
A study published in April 2011 in the “Archives of Ophthalmology” found that people who ate more foods with vitamin D, or who took vitamin D supplements, were less likely to develop age-related macular degeneration. Specifically, researchers measured blood levels of vitamin D in 1,313 women under the age of 75 and found that higher levels of vitamin D were associated with a 59 percent reduced risk of developing early macular degeneration.
Vitamin D Deficiency
According to the Office of Dietary Supplements, serum concentration of calcidiol is the best indication of vitamin D status, and levels below 37.5 nanomoles per liter are considered deficient. The recommended daily amounts for vitamin D are 400 international units for infants, whereas most adults require 600 to 700 IU depending on age. Vitamin D is fat soluble and stored in the body for long periods, so deficiency symptoms can take many months to manifest, or years, as is the case with macular degeneration.
Nutrients for the Cornea
Common initial vitamin D deficiency symptoms include severe fatigue, profuse sweating, muscle aches, bone pain and depression. Muscle weakness eventually develops with long-term deficiency, which can affect the small muscles of the eye responsible for focusing the lens, as cited in “Vitamins: Fundamental Aspects in Nutrition and Health.” Consequently, blurry vision is possible with chronic lack of vitamin D. Other deficiency-related symptoms that could affect eyesight include reduced immunity and higher risks of infection, hypertension and Type 2 diabetes, which could both lead to blood vessel damage to the small arteries supplying blood to the eye.
Vitamin D Sources
The best source of vitamin D is the sun, which triggers the synthesis of it within skin. Certain frequencies of UVB radiation are required, though, which occur only seasonally in most regions in the United States. Vitamin D is not especially prevalent in foods, but good sources include milk, fish and fortified margarines, cereals and juices.
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Nutrients for the Cornea
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- “Textbook of Medical Physiology”; Arthur C. Guyton, et al.; 2000
- The National Eye Institute: Summary of Eye Disease Prevalence Data: Macular Degeneration
- “Archives of Ophthalmology”; Vitamin D Status and Early Age-Related Macular Degeneration in Postmenopausal Women; A. Millen, et al.; April 2011
- Office of Dietary Supplements: Vitamin D Fact Sheet
- “Vitamins: Fundamental Aspects in Nutrition and Health”; G. Combs; 2008
- American Academy of Ophthalmology. What is macular degeneration? February 28, 2020.
- Thiele S, Nadal J, Pfau M, et al. Prognostic value of intermediate age-related macular degeneration phenotypes for geographic atrophy progression. Br J Ophthalmol. 2020;bjophthalmol-2020-316004. doi:10.1136/bjophthalmol-2020-316004
- Brown EE, Lewin AS, Ash JD. Mitochondria: Potential targets for protection in age-related macular degeneration. Adv Exp Med Biol. 2018;1074:11‐17. doi:10.1007/978-3-319-75402-4_2
- Heesterbeek TJ, Lechanteur YTE, Lorés-Motta L, et al. Complement activation levels are related to disease stage in AMD. Invest Ophthalmol Vis Sci. 2020;61(3):18. doi:10.1167/iovs.61.3.18
- Kassa E, Ciulla TA, Hussain RM, Dugel PU. Complement inhibition as a therapeutic strategy in retinal disorders. Expert Opin Biol Ther. 2019;19(4):335‐342. doi:10.1080/14712598.2019.1575358
- American Academy of Ophthalmology. Promising new treatments for AMD. February 3, 2020.
- Shaw LT, Mackin A, Shah R, et al. Risuteganib-a novel integrin inhibitor for the treatment of non-exudative (dry) age-related macular degeneration and diabetic macular edema [published online ahead of print, 2020 May 13]. Expert Opin Investig Drugs. 2020;1‐7. doi:10.1080/13543784.2020.1763953
- Wang B, Wang L, Gu S, et al. D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration. Signal Transduct Target Ther. 2020;5(1):20. Published 2020 Mar 4. doi:10.1038/s41392-020-0122-1
Owen Bond began writing professionally in 1997. Bond wrote and published a monthly nutritional newsletter for six years while working in Brisbane, Australia as an accredited nutritionalist. Some of his articles were published in the "Brisbane Courier-Mail" newspaper. He received a Master of Science in nutrition from the University of Saskatchewan.