Monistat 3 Combination Pack Side Effects

Monistat, also known as miconazole nitrate, is an over-the-counter antifungal medication used to treat vaginal yeast infections 12. Symptoms of a vaginal yeast infection include itching, irritation, burning during urination and thick, white vaginal discharge. The Monistat 3 Combination Pack is a three-day yeast infection treatment. The pack includes three doses of miconazole nitrate for internal vaginal use as well as an external miconazole cream that helps relieve the itching and burning commonly associated with yeast infections 12.

Is This an Emergency?

If you are experiencing serious medical symptoms, seek emergency treatment immediately.

Transient Side Effects

Monistat has several transient side effects that should lessen or completely resolve as the body gets used to this medication 3. According to, a headache is one of the most commonly reported transient side effects 3. Wearing loose-fitting clothing made from natural fibers that allow for air circulation may help alleviate some of these symptoms and speed up healing.

Skin Irritation

Skin irritation can occur after using the external itch relief cream included in the Monistat 3 Combination pack 1. According to, side effects commonly associated with topical miconazole use include blistering, burning, redness, skin rash or irritation at the application site 234. Patients using Monistat external itch relief cream should not apply any other skin medications or lotions to the affected area unless directed by their physician 1.

Allergic Reactions

Some first-time users may experience an allergic reaction to Monistat. Side effects associated with a severe allergic reaction to this drug include:

  • shortness of breath
  • difficulty swallowing
  • chest tightness
  • swelling of the lips
  • face or tongue
  • according to 3

If you experience any of these side effects while using Monistat, stop using this drug immediately and seek emergency medical assistance 3. Users may also experience milder allergy symptoms such as hives or rash.

Side Effects Requiring Medical Evaluation

According to MedlinePlus, a publication of the National Institutes of Health, it is important to note that while Monistat is an over-the-counter medication, seeking a doctor’s advice prior to use is recommended if you are experiencing yeast infection symptoms for the first time or have any questions or concerns 2. Occasionally, women already using Monistat may develop additional symptoms indicative of other vaginal conditions 1. According to, women who develop fever, chills, lower abdominal, back or shoulder pain, nausea, vomiting or a foul-smelling discharge while taking Monistat need to be evaluated by their doctor to determine if they actually have a yeast infection. While it is possible to experience some of these side effects with a yeast infection, these symptoms are also associated with other conditions such as bacterial vaginosis or sexually transmitted diseases. Your doctor will decide whether continuing treatment with Monistat is right for you.