Melatonin and Alprazolam for Anxiety
Muscle tension, racing thoughts and nervousness are common symptoms of anxiety that make it difficult to relax. Although relaxation techniques such as deep breathing, yoga or meditation can be effective, they may not work for everyone. Over-the-counter supplements are available to help alleviate anxiety. In more severe cases, you may require an anti-anxiety medication to get some relief. Consult your doctor before you take anything to treat your symptoms of anxiety.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Melatonin
Melatonin is a hormone produced by the body that regulates your sleeping and waking patterns. It is also available as a supplement and works as an antioxidant. Melatonin supplements are used to treat insomnia, a common symptom of anxiety. Anxiety can interfere with your ability to fall asleep or cause you to toss and turn throughout the night. According to a study published in the January 2011 issue of "Clinical Medical Research and Opinion," sleep latency, sleep quality and quality of life improved among participants aged 18 to 80 who took prolonged-release melatonin over a three-week period 2.
- Melatonin is a hormone produced by the body that regulates your sleeping and waking patterns.
- According to a study published in the January 2011 issue of "Clinical Medical Research and Opinion," sleep latency, sleep quality and quality of life improved among participants aged 18 to 80 who took prolonged-release melatonin over a three-week period 2.
Alprazolam
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Alprazolam, brand name Xanax, is an anti-anxiety medication that is used to treat anxiety disorders as well as panic disorder, and may be prescribed for some cases of depression. It is a strong, habit-forming medication and is not prescribed to alleviate day-to-day anxiety or stress. The starting dosage is typically 0.25 mg or 0.5 mg per day and may be gradually increased up to 4 mg daily. The availability of alprazolam from sources outside of the United States has contributed to its abuse. Alprazolam obtained via the Internet may contain dangerous ingredients and can be harmful.
- Alprazolam, brand name Xanax, is an anti-anxiety medication that is used to treat anxiety disorders as well as panic disorder, and may be prescribed for some cases of depression.
- Alprazolam obtained via the Internet may contain dangerous ingredients and can be harmful.
Side Effects
Some side effects of melatonin include stomach pain, headaches, dizziness and daytime drowsiness. Drowsiness may dissipate if the dosage is reduced. Nightmares are also a possible side effect of melatonin. The side effects of alprazolam are much more severe. Alprazolam is highly addictive and can cause harmful withdrawal symptoms if its use is discontinued abruptly. Withdrawal symptoms may include:
- seizures
- insomnia
- depression
- vomiting
- nervousness
- muscle twitching or cramps
- Some side effects of melatonin include stomach pain, headaches, dizziness and daytime drowsiness.
Interactions
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Melatonin can have negative side effects as a result of interaction with a number of other types of medication. For example, caution should be taken when taking melatonin along with psychotropic medications such as antidepressants, antipsychotics or benzodiazpines, such as alprazolam. It can be dangerous when taken in combination with blood pressure medications or blood thinners. Alprazolam can interact with other psychotropic drugs, anticonvulsants and antihistaminics that also depress the central nervous system.
- Melatonin can have negative side effects as a result of interaction with a number of other types of medication.
Related Articles
References
- University of Maryland Medical Center: Melatonin
- "Current Medical Research and Opinion"; Prolonged Release Melatonin in the Treatment of Primary Insomnia: Evaluation of the Age Cut-off for Short- and Long-Term Response; A.G. Wade; January 2011
- University of Maryland Medical Center: Possible Interactions with Melatonin
- RxList.com: Xanax
- Buscemi N, Vandermeer B, Hooton N, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med 2005;20:1151-8. doi:10.1111/j.1525-1497.2005.0243.x
- James M, Tremea MO, Jones JS, Krohmer JR. Can melatonin improve adaptation to night shift? Am J Emerg Med 1998;16:367-70. doi:10.1016/s0735-6757(98)90129-2
- Fischer, S., Smolnik, R., Herms, M., Born, J., and Fehm, H. L. Melatonin acutely improves the neuroendocrine architecture of sleep in blind individuals. J Clin Endocrinol.Metab 2003;88(11):5315-5320. doi10.1210/jc.2003-030540
- Gringras P, Gamble C, Jones AP, et al; MENDS Study Group. Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial. BMJ. 2012 Nov 5;345:e6664. doi10.1136/bmj.e6664
- Jan, J. E., Hamilton, D., Seward, N., Fast, D. K., Freeman, R. D., and Laudon, M. Clinical trials of controlled-release melatonin in children with sleep- wake cycle disorders. J Pineal Res 2000;29(1):34-39.
- Nagtegaal JE, Laurant MW, Kerkhof GA, et al. Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. J Psychosom Res 2000;48:45-50. doi:10.1016/s0022-3999(99)00075-6
- Natural Standard. "Melatonin" Mayoclinic.com.
- PDRHealth. "Melatonin"
- Rossignol, D. A. and Frye, R. E. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev.Med.Child Neurol. 2011;53(9):783-792. doi:10.1111/j.1469-8749.2011.03980.x
- Sack RL, Brandes RW, Kendall AR, et al. Entrainment of free-running circadian rhythms by melatonin in blind people. N Engl J Med 2000;343:1070-7. doi:10.1056/NEJM200010123431503
Writer Bio
Barbara Aufiero has been writing health-related articles since 2008, specializing in mental health and health insurance. Aufiero resides in New York and holds a Master of Arts in psychology.