What does fact checked mean?
At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- PubMed.gov: Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cell
- PubMed.gov: Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cell
- PubMed.gov: Intestinal alkaline phosphatase secretion in oil-fed rats
- PubMed.gov: Intestinal alkaline phosphatase secretion in oil-fed rats
- PubMed Central: Zinc deficiency negatively affects alkaline phosphatase and the concentration of Ca, Mg and P in rat
- PubMed Central: Zinc deficiency negatively affects alkaline phosphatase and the concentration of Ca, Mg and P in rat
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
What Foods Raise Alkaline Phosphatase Levels?
Alkaline phosphatase is an enzyme that is present in every single tissue of the body, though it is concentrated in the liver, gallbladder, bones, kidneys, placenta and intestines. This enzyme plays a number of roles within the body, including but not limited to, aiding proper bone formation, protecting the intestinal tract from bacteria, aiding the digestion and breakdown of fats as well as vitamins B1, B2 and B6. Often high alkaline phosphatase is used as a test for bone, liver and kidney diseases, but there are also foods that can increase alkaline phosphatase levels.
Phosphorous
Phosphorous is the most important nutritional ingredient for creating alkaline phosphate in the body, and the amount of phosphorous needed by our body each day is second only to calcium. In addition to helping create alkaline phosphatase, phosphorous is important for energy production, healthy bone formation, DNA production and calcium absorption. The majority of phosphorous in the diet comes from soft drinks, though it is far better to gain it from healthy food sources such as:
- yogurt
- lentils
- salmon
- halibut
- chicken
- turkey
- almonds
- eggs
Fats
Does Magnesium Help You Lose Weight?
Learn More
Alkaline phosphatase plays a role in the digestion and absorption of fats in the intestinal tract, and some types of oils have been found to directly stimulate alkaline phosphate production 3. In particular, one study published in the journal "Digestive Diseases and Sciences" in 2007 found that animals fed cod liver oil, coconut oil and corn oil had higher alkaline phosphate levels than normal.
Zinc
Adequate dietary zinc is important for the production of alkaline phosphatase in the body and deficiencies of zinc will result in low alkaline phosphatase in the blood. Supplementing with zinc will increase alkaline phosphatase to healthy levels quickly. Zinc also plays a role in healthy bone formation, supporting the immune system and supporting healthy skin. This mineral can be found in foods such as:
- oysters
- pumpkin seeds
- ginger root
- pecans
- peas
- Brazil nuts
Supplemental zinc should never exceed 30 mg per day.
- Adequate dietary zinc is important for the production of alkaline phosphatase in the body and deficiencies of zinc will result in low alkaline phosphatase in the blood.
Vitamin B12
Vitamins That Make the Body Alkaline
Learn More
Deficiencies in vitamin B12 lead to pernicious anemia, a condition which is linked to low alkaline phosphate levels as well as bone diseases, such as osteoporosis. A study in Korea by the Asian Medical Center found that pernicious anemia resulted in decreased levels of bone formation and decreased production of alkaline phosphatase from bone cells. Vitamin B12 can be found in most meats, fish, eggs, dairy products and sea vegetables. Vegetarians and vegans are recommended to supplement with 2 mcg of vitamin B12 daily, best taken as a sub-lingual tablet absorbed under the tongue.
- Deficiencies in vitamin B12 lead to pernicious anemia, a condition which is linked to low alkaline phosphate levels as well as bone diseases, such as osteoporosis.
- A study in Korea by the Asian Medical Center found that pernicious anemia resulted in decreased levels of bone formation and decreased production of alkaline phosphatase from bone cells.
Vitamin A
Vitamin A helps to stimulate production of alkaline phosphatase from bone cells, and may help to regulate production of alkaline phosphatase in the intestinal tract 3. Increasing vitamin A should be done with caution, as this nutrient is stored within our fat cells throughout the year. Vitamin A is also found within fish oils such as salmon oil and cod liver oil.
Related Articles
References
- "The Encyclopaedia of Healing Foods;" Pizzorno, Joseph; 2005
- PubMed.gov: Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cell
- PubMed.gov: Intestinal alkaline phosphatase secretion in oil-fed rats
- PubMed Central: Zinc deficiency negatively affects alkaline phosphatase and the concentration of Ca, Mg and P in rat
- Li D, Lv H, Hao X, Hu B, Song Y. Prognostic value of serum alkaline phosphatase in the survival of prostate cancer: evidence from a meta-analysis. Cancer Manag Res. 2018;10:3125-3139. doi:10.2147/CMAR.S174237
- Siddique A, Kowdley KV. Approach to a patient with elevated serum alkaline phosphatase. Clin Liver Dis. 2012;16(2):199-229. doi:10.1016/j.cld.2012.03.012
- Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed.
Writer Bio
Joel Le Blanc is a professional writer for various websites. Le Blanc is currently a student at the University of Canterbury, where he studies English literature, folklore and creative writing. He holds a Diploma in Herbal Medicine and has studied massage, nutrition, bach flowers and reiki.