The liver is the largest gland in the human body and the sole internal organ that has the ability to regenerate itself. Its key functions include secretion of bile, storing vitamins, clotting blood and destroying bacteria. The liver also acts as a detoxification agent by disposing of toxic substances through the kidneys and bowels.
The kidneys maintain water balance in the body, assist with chemical balance and remove waste products. There are a number of vitamins essential for effective functioning of the liver and kidneys.
According to the University of Maryland Medical Center, vitamin B6 is essential for a healthy liver and kidneys 36. Vitamin B6 is a water-soluble vitamin that plays a key role in converting carbohydrates into energy and removing toxins from the body. Healthy sources of vitamin B6 include:
Vitamin B6 also assists in maintaining a healthy immune system, metabolism of proteins and reducing kidney stone occurrence.
What Is the General Function of Vitamins?
Vitamin D is a fat-soluble vitamin which is crucial for absorption of calcium and for healthy immune function. The Colorado State University Website states that dietary calcium is not absorbed efficiently in the absence of vitamin D. People who suffer from liver disease may benefit from vitamin D which is also essential for efficient kidney function 34. It is believed to slow down the progression of chronic liver disease as well, according to the U.S. National Library of Medicine. Important food sources of vitamin D include:
- leafy vegetables
- fish oils
- fortified cereals
- Vitamin D is a fat-soluble vitamin which is crucial for absorption of calcium and for healthy immune function.
- The Colorado State University Website states that dietary calcium is not absorbed efficiently in the absence of vitamin D. People who suffer from liver disease may benefit from vitamin D which is also essential for efficient kidney function 3.
Vitamin C is a water soluble vitamin that protects the liver by stimulating the production of detoxifying enzymes and helps with the absorption of iron. It also aids in preventing and dissolving kidney stones. Vitamin C intake with B-complex vitamins can assist in lessening liver disorders like cirrhosis and hepatitis. Major sources include citrus fruits like oranges and grapefruit as well as kiwi, pineapple, broccoli and red pepper.
- Vitamin C is a water soluble vitamin that protects the liver by stimulating the production of detoxifying enzymes and helps with the absorption of iron.
- Vitamin C intake with B-complex vitamins can assist in lessening liver disorders like cirrhosis and hepatitis.
Foods and Vitamins to Help Heal Nerve Endings
Vitamin E is a fat soluble vitamin which prevents vitamin A and essential fatty acids from being oxidized in the cells. As an antioxidant, it assists the liver with the process of detoxification and in breaking down fats. According to a study by the U.C. Irvine College of Medicine, high doses of vitamin E may play a key role in reducing blood pressure, especially in patients with kidney disease. Another study by the University of Essex Department of Biological and Chemical Sciences indicates that dietary supplementation with Vitamin E may cut down oxidative stress thereby slowing the progression of kidney disease 23. Healthy sources of vitamin E are nuts, broccoli and spinach.
- Vitamin E is a fat soluble vitamin which prevents vitamin A and essential fatty acids from being oxidized in the cells.
- Another study by the University of Essex Department of Biological and Chemical Sciences indicates that dietary supplementation with Vitamin E may cut down oxidative stress thereby slowing the progression of kidney disease 2.
What Is the General Function of Vitamins?
Foods and Vitamins to Help Heal Nerve Endings
Vitamins for an Overactive Bladder
Vitamin B5 for Weight Loss
Supplements for Gallbladder Removal
Anemia & Vitamin K
Foods That Heal Nerve Damage
7 Functions of the Liver
Can Vitamins Prevent the Flu?
Vitamins For Pancreatitis
- MedlinePlus: Vitamin D
- PubMed: Vitamin E May Slow Kidney Failure Owing to Oxidative Stress
- Oregon State University: Vitamin C
- Colorado State University: Vitamin D; Calcitriol
- Linus Pauling Institute: Vitamin D
- University of Maryland Medical Center: Vitamin B6; Pyridoxine
- Holick MF, Gordon CM. Patient Guide to Vitamin D Deficiency. The Journal of Clinical Endocrinology & Metabolism. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a
- Sunyecz JA. The use of calcium and vitamin D in the management of osteoporosis. Ther Clin Risk Manag. 2008;4(4):827-836. doi:10.2147/tcrm.s3552
- Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168(11):1174-1180. doi:10.1001/archinte.168.11.1174
- Gorham ED, Garland CF, Garland FC, et al. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med. 2007;32(3):210-216. doi:10.1016/j.amepre.2006.11.004
- Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. The American Journal of Clinical Nutrition. 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586
- Prentice RL, Pettinger MB, Jackson RD, et al. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Osteoporos Int. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2
- Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91(5):1255-1260. doi:10.3945/ajcn.2009.29094
- Salehpour A, Hosseinpanah F, Shidfar F, et al. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. Nutr J. 2012;11:78. doi:10.1186/1475-2891-11-78
- Carrillo AE, Flynn MG, Pinkston C, et al. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. 2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014
- Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. Front Endocrinol. 2018;9:550. doi:10.3389/fendo.2018.00550
- Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(1):53-58. doi:10.1210/jc.2010-2704
- Bouillon R, Van Schoor NM, Gielen E, et al. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab. 2013;98(8):E1283-E1304. doi:10.1210/jc.2013-1195
- American Academy of Dermatology. Position Statement of Vitamin D. 2010.
- Taksler GB, Cutler DM, Giovannucci E, Keating NL. Vitamin D deficiency in minority populations. Public Health Nutr. 2015;18(3):379-391. doi:10.1017/S1368980014000457
- Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-1930. doi:10.1210/jc.2011-0385
- Cannell JJ, Vieth R, Umhau JC, et al. Epidemic Influenza and Vitamin D. Epidemiol Infect. 2006; 134:1129-40.
- Carrillo AE1, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of Vitamin D Supplementation During a Resistance Training Intervention on Body Composition, Muscle Function, and Glucose Tolerance in Overweight and Obese Adults. Clin Nutr. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. Epub 2012 Aug 31.
- Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009; 169:384-90.
- Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and Risk of Myocardial Infarction in Men: a Prospective Study. Arch Intern Med. 2008; 168:1174-80.
- Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. Am J Prev Med. 2007 Mar;32(3):210-6.
- Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9.
- Holick MF. Vitamin D. In: Shils M, Olson J, Shike M, Ross AC, ed. Modern Nutrition in Health and Disease, 9th ed. Baltimore: Williams and Wilkins, 1999.
- National Institutes of Health Office of Dietary Supplements. Vitamin D: Dietary Supplement Fact Sheet. University of Ottawa Evidence-based Practice Center. Effectiveness and Safety of Vitamin D in Relation to Bone Health. Agency for Healthcare Research and Quality. Aug 2007: 07-E013.
- Salehpour A1, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M. A 12-week Double-blind Randomized Clinical Trial of Vitamin D₃ Supplementation on Body Fat Mass in Healthy Overweight and Obese Women. Nutr J. 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78.
- Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. Am J Clin Nutr. 2010 91:1255-60. Epub 2010 Mar 10.
- Wilkins, Consuelo H. and Yvette I. Sheline, et al. “Vitamin D Deficiency Is Associated with Low Mood and Worse Cognitive Performance in Older Adults.” American Journal of Geriatric Psychiatry 14 (2006): 1032-40.
ShaeLee Chatterton began writing professionally in 2007. She has written articles for "Women's Health" magazine online and edited for LA Splash Magazine. She is a fitness nutrition coach through the National Exercise and Sports Trainer Association and is certified as a personal trainer by the American Council on Exercise. Chatterton earned a Bachelor of Arts in exercise science and communications at Boise State University.