Biotin 1,000 mcg Side Effects
Biotin, or vitamin B-7, is a compound that is involved in the normal metabolism of food in your digestive system. Biotin can be found naturally in small amounts in some foods, especially yeasts, breads, eggs, some meats and a variety of other food items. You can also use biotin as a nutritional supplement for its potential effects on your health and well-being. Too much biotin can cause some side effects. Talk with your doctor about biotin supplements to make sure you are not taking in too much.
Recommended Dietary Intake
According to the Linus Pauling Institute at Oregon State University, the average daily intake of biotin through the normal consumption of food is between 35 and 60 mcg per day. It is recommended that adults acquire about 30 mcg of biotin daily, whereas adolescents and children require less biotin to meet their daily needs. Biotin supplements can be taken to help correct a biotin deficiency, although a deficiency is very rare.
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The Linus Pauling Institute states that very high doses of biotin may help treat excessively high fasting blood glucose levels in patients with non-insulin dependent diabetes. Diabetics who used 9,000 mcg a day for one month were able to decrease their fasting blood glucose levels by 45 percent. However, a 2004 study published in "The American Journal of Clinical Nutrition" using 15,000 mcg of biotin daily was not able to replicate these results.
According to the Food and Nutrition Board's dietary reference intake, biotin is non-toxic. The Mayo Clinic states that biotin causes no side effects when taken in doses of 10 mg, or 10,000 mcg, daily. As much as 200,000 mcg of biotin daily has been well-tolerated in patients with hereditary disorders without any side effects. 200,000 mcg, or 200 mg, is well above the daily requirements for human consumption, and consuming that much biotin through food and supplements is highly unlikely.
- According to the Food and Nutrition Board's dietary reference intake, biotin is non-toxic.
- The Mayo Clinic states that biotin causes no side effects when taken in doses of 10 mg, or 10,000 mcg, daily.
The Food and Nutrition Board cites several Japanese studies which found that 10 mg of biotin supplementation for every 100 g of body weight in pregnant rats can inhibit fetal growth, potentially causing birth defects. The dosage used on the rats would be the equivalent to about 7 g of biotin for a 154 lb. person. Because of the exceptionally high amount of biotin required to cause these effects in rats, the Food and Nutrition Board decided not to include the results in their recommendation for the tolerable upper intake level for humans.
- The Food and Nutrition Board cites several Japanese studies which found that 10 mg of biotin supplementation for every 100 g of body weight in pregnant rats can inhibit fetal growth, potentially causing birth defects.
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- Linus Pauling Institute; Biotin; Jane Higdon; 2004
- "The American Journal of Clinical Nutrition"; Effects of Biotin on Pyruvate Carboxylase, Acetyl-CoA Carboxylase, Propionyl-CoA Carboxylase, and Markers for Glucose and Lipid Homeostasis in Type 2 Diabetic Patients and Nondiabetic Subjects; A. Baez-Saldana, et al.; February 2004
- Food and Nutrition Board: Intake of Biotin
- The Mayo Clinic: Biotin
- Romero-Navarro, G., Cabrera-Valladares, G., German, M. S., Matschinsky, F. M., Velazquez, A., Wang, J., & Fernandez-Mejia, C. (1999). Biotin regulation of pancreatic glucokinase and insulin in primary cultured rat islets and in biotin-deficient rats. Endocrinology, 140(10), 4595-4600.
- Revilla-Monsalve, C., Zendejas-Ruiz, I., Islas-Andrade, S., BÃ¡ez-SaldaÃ±a, A., Palomino-Garibay, M. A., HernÃ¡ndez-QuirÃ³z, P. M., & Fernandez-Mejia, C. (2006). Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia. Biomedicine & Pharmacotherapy, 60(4), 182-185.
- Colombo, V. E., Gerber, F., Bronhofer, M., & Floersheim, G. L. (1990). Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy. Journal of the American Academy of Dermatology, 23(6), 1127-1132.
- TrÃ¼eb, R. M. (2016). Serum biotin levels in women complaining of hair loss. International Journal of Trichology, 8(2), 73.
- Durance, T. D. (1991). Residual Avid in Activity in Cooked Egg White Assayed with Improved Sensitivity. Journal of Food Science, 56(3), 707-709.
Joe King began writing fitness and nutrition articles in 2001 for the "Journal of Hyperplasia Research" and Champion Nutrition. As a personal trainer, he has been helping clients reach their fitness goals for more than a decade. King holds a Bachelor of Science in kinesiology from California State University, Hayward, and a Master of Science in exercise physiology from California State University, East Bay.