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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- PubMed: Therapeutic Potential of Resveratrol in Alzheimer's Disease
- PubMed: Therapeutic Potential of Resveratrol in Alzheimer's Disease
- Linus Pauling Institute at Oregon State University: Resveratrol
- PubMed: Longevity Nutrients Resveratrol, Wines and Grapes
- PubMed: Longevity Nutrients Resveratrol, Wines and Grapes
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What Are the Benefits of Japanese Knotweed?
Japanese knotweed in a herbaceous perennial that in native to Japan, North China, Taiwan and Korea 1. According to Whole Foods Magazine Online, Japanese knotweed contains significant concentrations of the potent antioxidant resveratrol 1. Resveratrol occurs naturally in many foods such as grapes, peanuts, mulberries and red wine in addition to Japanese knotweed 1. Consumption of Japanese knotweed promotes several beneficial health effects due to the presence of resveratrol 1.
Alzheimer's Disease/Dementia
The resveratrol concentration in Japanese knotweed has shown to have preventative effects against Alzheimer's disease 12. According to PubMed, a study conducted at the Feinstein Institute of Medical Research in Manhasset, New York revealed that intake of resveratrol has beneficial properties against the neurodegenerative processes that lead to Alzheimer's disease 2. The research was performed on cell cultures and animal subjects, however, the results of this study yields promising results for Alzheimer's disease in the human population.
Cardiovascular Disease
Hawaiian Spirulina Benefits
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The antioxidant properties of Japanese knotweed can have preventative effects against cardiovascular disease 1. According to Linus Pauling Institute at Oregon State University, the presence of resveratrol in Japanese knotweed can promote the phenomenon commonly known as the "French Paradox." The "French Paradox" refers to the fact that the incidence of cardiovascular disease is very low in France even though the French population consumes a diet very rich in saturated fat and a high percentage of cigarette smoking among French population 13. The reason for the low incidence of coronary disease is attributed to the resveratrol concentration in the high quantity of red wines that is commonly consumed by the French population. Red wine and Japanese knotweed both contain high concentrations of resveratrol which can equally provide protection to the cardiovascular system 1.
Cancer Prevention
Resveratrol contained in Japanese knotweed can also have preventative effects against some forms of cancer 1. According to the Linus Pauling Institute at Oregon State University, resveratrol has proven to have preventative properties against many forms of cancer, such as:
- breast
- prostate
- colon
- pancreatic
- thyroid 3
The data was obtained by inducing human cells with chemical carcinogens. Resveratrol was not proven effective against lung cancer induced by the carcinogens in cigarette smoke.
Related Articles
References
- Columbia University: Japanese Knotweed
- PubMed: Therapeutic Potential of Resveratrol in Alzheimer's Disease
- Linus Pauling Institute at Oregon State University: Resveratrol
- PubMed: Longevity Nutrients Resveratrol, Wines and Grapes
- Clinical Trials: Randomized Trial of a Nutritional Supplement in Alzheimer's Disease
- Chung JH, Manganiello V, Dyck JR. Resveratrol as a calorie restriction mimetic: therapeutic implications. Trends Cell Biol. 2012;22(10):546‐554. doi:10.1016/j.tcb.2012.07.004
- Liu Y, Ma W, Zhang P, He S, Huang D. Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials. Clin Nutr. 2015;34(1):27‐34. doi:10.1016/j.clnu.2014.03.009
- Sahebkar A, Serban C, Ursoniu S, et al. Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors--Results from a systematic review and meta-analysis of randomized controlled trials. Int J Cardiol. 2015;189:47‐55. doi:10.1016/j.ijcard.2015.04.008
- Semba RD, Ferrucci L, Bartali B, et al. Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults. JAMA Intern Med. 2014;174(7):1077‐1084. doi:10.1001/jamainternmed.2014.1582
- Tan L, Wang W, He G, et al. Resveratrol inhibits ovarian tumor growth in an in vivo mouse model. Cancer. 2016;122(5):722‐729. doi:10.1002/cncr.29793
- Poschner S, Maier-Salamon A, Zehl M, et al. Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation. Front Pharmacol. 2018;9:742. doi:10.3389/fphar.2018.00742
- Heebøll S, Kreuzfeldt M, Hamilton-Dutoit S, et al. Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease. Scand J Gastroenterol. 2016;51(4):456‐464. doi:10.3109/00365521.2015.1107620
- Mukherjee S, Dudley JI, Das DK. Dose-Dependency of Resveratrol in Providing Health Benefits. Dose Response. 2010;8(4):478‐500. doi:10.2203/dose-response.09-015.Mukherjee
- Weiskirchen S, Weiskirchen R. Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy? Adv Nutr. 2016;7(4):706‐718. doi:10.3945/an.115.011627
- American Heart Association. Is drinking alcohol part of a healthy lifestyle? Updated December 30, 2019.
Writer Bio
Robert Shifko has more than 17 years' experience in the health care industry. Throughout his career, he has gained experience in pharmacologic research, clinical nuclear medicine, and most recently radiation health physics. He has obtained several certifications in nuclear medicine, epidemiology, biostatistics and as a medical radiation safety officer. He has always supported LIVESTRONG.