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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- “Journal of Medicinal Food”; Effects of Pomegranate Juice and Extract Polyphenols on Platelet Function; T. Mattiello, et al.; April 2009
- “Journal of Medicinal Food”; Effects of Pomegranate Juice and Extract Polyphenols on Platelet Function; T. Mattiello, et al.; April 2009
- “Drugs under Experimental and Clinical Research”; Pomegranate Juice Flavonoids Inhibit Low-Density Lipoprotein Oxidation and Cardiovascular Diseases: Studies in Atherosclerotic Mice and in Humans; M. Aviram; 2002
- “Drugs under Experimental and Clinical Research”; Pomegranate Juice Flavonoids Inhibit Low-Density Lipoprotein Oxidation and Cardiovascular Diseases: Studies in Atherosclerotic Mice and in Humans; M. Aviram; 2002
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The Effect of Pomegranate Juice on Blood Clots
Each year, hundreds of thousands of American develop new blood clots that often lead to disability and death, according to the U.S 1. Surgeon General. For 4,000 years, folk medicine practitioners have been using extracts from the juice of red pomegranate fruits to treat a variety of health conditions including blood vessel disorders. Modern researchers investigating those effects are finding that pomegranate juice may help promote cardiovascular health.
Identification
Blood clots can form in your arteries or in a vein, known as deep vein thrombosis. Clots are formed by platelet cells that form over skin wounds and around injured blood vessels to help your body heal. After the clots have done their job, your body dissolves them. When something goes wrong with that process, the clot doesn’t dissolve, and pieces of clots in veins can travel to other parts of the body and lead to heart problems, lung clots or strokes that can be life-threatening. When clots form in the arteries that supply blood to your heart, they can cause heart attacks.
- Blood clots can form in your arteries or in a vein, known as deep vein thrombosis.
- When clots form in the arteries that supply blood to your heart, they can cause heart attacks.
Pomegranate Health Benefits
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Free radicals are molecules in your body that attack and damage DNA and cells, leading to disease. Free radicals can oxidize unhealthy LDL cholesterol, converting it into plaques that clog your arteries Antioxidants are compounds found in many plant sources, including pomegranates and pomegranate juice, which prevent the conversion of cholesterol into plaques. The type of antioxidant found in pomegranates and other fruits is called a polyphenol, with pomegranates having higher levels of polyphenols than red wine, blueberry juice and green tea.
Atherosclerosis
When plaques build up on the inside of your arteries, it’s called atherosclerosis. This condition is caused in part by the accumulation of LDL and fats and increases the risk of blood clots forming in those arteries. An article published in 2002 in “Drugs under Experimental and Clinical Research” summarized research into the effect of pomegranate juice on atherosclerosis in both mice and human subjects 4. It reported that pomegranate polyphenols are effectively able to prevent atherosclerotic plaques and LDL oxidation.
- When plaques build up on the inside of your arteries, it’s called atherosclerosis.
- It reported that pomegranate polyphenols are effectively able to prevent atherosclerotic plaques and LDL oxidation.
Platelet Formation
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Researchers in Rome published findings in the April 2009 issue of the “Journal of Medicinal Food” that showed polyphenols in pomegranate juice are able to inhibit platelet clumping that forms clots 3. Pomegranate juice also protected against the proliferation of thromboxane, a substance made by platelets that causes blood clotting and constriction of blood vessels.
Considerations
Pomegranate juice may interact with anticoagulant drugs taken to prevent blood clots, increasing their effects. Talk to your doctor before using pomegranate juice if you’re taking blood thinners and don’t consume the juice at least two weeks before a scheduled surgery. There are a few reports of people with plant allergies who experienced an allergic reaction to pomegranate.
- Pomegranate juice may interact with anticoagulant drugs taken to prevent blood clots, increasing their effects.
- There are a few reports of people with plant allergies who experienced an allergic reaction to pomegranate.
Related Articles
References
- American Society of Hematology: Blood Clots
- RaySahelian.com; Pomegranate Juice; Dr. Ray Sahellian
- “Journal of Medicinal Food”; Effects of Pomegranate Juice and Extract Polyphenols on Platelet Function; T. Mattiello, et al.; April 2009
- “Drugs under Experimental and Clinical Research”; Pomegranate Juice Flavonoids Inhibit Low-Density Lipoprotein Oxidation and Cardiovascular Diseases: Studies in Atherosclerotic Mice and in Humans; M. Aviram; 2002
- Pomegranate. Professional Monograph. Natural Medicine Database. Therapeutic Resource Center. 5/6/2019
- Bassiri-Jahromi S. Punica granatum (Pomegranate) activity in health promotion and cancer prevention. Oncol Rev. 2018;12(1):345. Published 2018 Jan 30. doi:10.4081/oncol.2018.345
- Bhadbhade SJ, Acharya AB, Rodrigues SV, et al. The antiplaque efficacy of pomegranate mouthrinse. Quintessence International. 2011;42(1):29-36.
- Danesi F, Ferguson LR. Could Pomegranate Juice Help in the Control of Inflammatory Diseases?. Nutrients. 2017;9(9):958. Published 2017 Aug 30. doi:10.3390/nu9090958
- Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metabolism and Disposition. 33.5 (2005):644-8.
- Ismail T, Sestili P, Akhtar S. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. Journal of Ethnopharmacology. 2012;143(2):397-3405.
- Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH. Inhibitory effects of fruit juices on CYP3A activity. Drug Metabolism and Disposition. 34.4 (2006):521-3.
- Sahebkar, A., Ferri, C., Giorgini, P., Bo, S., Nachtigal, P., & Grassi, D. (2017). Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research, 115, 149–161. doi:10.1016/j.phrs.2016.11.018
- Sharma P, McClees SF, Afaq F. Pomegranate for Prevention and Treatment of Cancer: An Update. Molecules. 2017;22(1):177. Published 2017 Jan 24. doi:10.3390/molecules22010177
- Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. American Journal of Cardiology. 98.5 (2006):705-6.
- Taheri Rouhi SZ, Sarker MMR, Rahmat A, Alkahtani SA, Othman F. The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague-Dawley rats [published correction appears in BMC Complement Altern Med. 2017 Apr 13;17 (1):214]. BMC Complement Altern Med. 2017;17(1):156. Published 2017 Mar 14. doi:10.1186/s12906-017-1667-6
- Wang D, Özen C, Abu-Reidah IM, et al. Vasculoprotective Effects of Pomegranate (Punica granatum L.). Front Pharmacol. 2018;9:544. Published 2018 May 24. doi:10.3389/fphar.2018.00544
- Zarfeshany A, Asgary S, Javanmard SH. Potent health effects of pomegranate. Adv Biomed Res. 2014;3:100. Published 2014 Mar 25. doi:10.4103/2277-9175.129371
Writer Bio
Bonnie Singleton has been writing professionally since 1996. She has written for various newspapers and magazines including "The Washington Times" and "Woman's World." She also wrote for the BBC-TV news magazine "From Washington" and worked for Discovery Channel online for more than a decade. Singleton holds a master's degree in musicology from Florida State University and is a member of the American Independent Writers.