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- "Molecular Nutrition and Food Research"; Effects of Garlic on Platelet Biochemistry and Physiology; K. Rahman; November 2007
- "Molecular Nutrition and Food Research"; Effects of Garlic on Platelet Biochemistry and Physiology; K. Rahman; November 2007
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Does Garlic Help Raise Platelet Count?
Garlic, a pungent spice used to enliven many food dishes, has a long history of medicinal use to treat everything from the common cold to cancer. Garlic may also play a part in protecting against heart disease by its effect on platelets, irregularly shaped cell fragments that are the smallest of the blood cells, according to the University of Oklahoma Health Sciences Center 3. Platelets clump together at the site of injury to help stop bleeding. Taking garlic doesn't produce more platelets, but it does decrease platelet aggregation, the ability to stick together.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Garlic's Actions on Platelets
Laboratory studies show that garlic has multiple actions that inhibit platelets from sticking together. Garlic inhibits formation of thromboxane A2, a compound that binds to platelets and activates their clotting actions. Taking garlic can also decrease the ability of platelets to bind with fibrinogen, a protein that helps to form blood clots to seal off bleeding blood vessels. Garlic does not increase platelet production in the bone marrow.
- Laboratory studies show that garlic has multiple actions that inhibit platelets from sticking together.
- Taking garlic can also decrease the ability of platelets to bind with fibrinogen, a protein that helps to form blood clots to seal off bleeding blood vessels.
Effects
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Platelet aggregation plays a role in the development of stroke and heart disease. Build up of plaque, cholesterol and debris deposits in the walls of blood vessels can damage the blood vessels. Platelets stick to the injured blood vessels, forming blood clots that further narrow the interior of the vessel and impede blood flow. Pieces of the clots can break off and lodge in blood vessels that supply the brain with blood, causing a stroke. Because garlic reduces platelet aggregation, clots are less likely to form. Since fewer platelets stick to damaged areas, more platelets circulate in the blood.
- Platelet aggregation plays a role in the development of stroke and heart disease.
- Pieces of the clots can break off and lodge in blood vessels that supply the brain with blood, causing a stroke.
Garlic and the Platelet Count
Garlic doesn't helps your body make more platelets, but it does prevent platelets from sticking together. A normal platelet count ranges from 150,000 to 400,000 units per liter. If you have a very high platelet count, you may have an increased risk of platelet aggregation; taking garlic may help to reduce the blood's ability to form clots.
Considerations
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If you have an abnormally low platelet count, you may have an increased tendency to bleed from minor injuries or even when you haven't injured yourself at all. Do not take garlic to build up your platelet count, because it can increase your tendency to bleed, worsening the problem, and it will not increase your platelet count. If you take blood thinning medications, garlic could potentiate their effects, the University of Maryland Medical Center warns 1. If you have any type of platelet disorder, ask your doctor before taking garlic.
- If you have an abnormally low platelet count, you may have an increased tendency to bleed from minor injuries or even when you haven't injured yourself at all.
- Do not take garlic to build up your platelet count, because it can increase your tendency to bleed, worsening the problem, and it will not increase your platelet count.
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References
- University of Maryland Medical Center; Garlic; Steven Ehrlich; November 2008
- "Molecular Nutrition and Food Research"; Effects of Garlic on Platelet Biochemistry and Physiology; K. Rahman; November 2007
- Oklahoma University State Science Center: Platelets
- Khan A, Haider I, Ayub M, Khan S. Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus. F1000Res. 2017;6:126. doi:10.12688/f1000research.10763.3
- Rivera FJ, Kazanis I, Ghevaert C, Aigner L. Beyond Clotting: A Role of Platelets in CNS Repair? Front Cell Neurosci. 2015;9:511. doi:10.3389/fncel.2015.00511
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- Panova-noeva M, Schulz A, Hermanns MI, et al. Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study. Blood. 2016;127(2):251-9. doi:10.1182/blood-2015-07-660308
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- Yan K, Ding B, Huang J, Dai Y, Xiong S, Zhai Z. Normal platelet counts mask abnormal thrombopoiesis in patients with chronic myeloid leukemia. Oncol Lett. 2015;10(4):2390–2394. doi:10.3892/ol.2015.3502
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- Cumhur Cure M, Cure E, Yuce S, Yazici T, Karakoyun I, Efe H. Mean platelet volume and vitamin D level. Ann Lab Med. 2014;34(2):98–103. doi:10.3343/alm.2014.34.2.98
- Al-sweedan SA, Alhaj M. The effect of low altitude on blood count parameters. Hematol Oncol Stem Cell Ther. 2012;5(3):158-61. doi:10.5144/1658-3876.2012.158
- Alper AT, Sevimli S, Hasdemir H, et al. Effects of high altitude and sea level on mean platelet volume and platelet count in patients with acute coronary syndrome. J Thromb Thrombolysis. 2009;27(2):130-4. doi:10.1007/s11239-007-0159-9
- Ciftci H, Yeni E, Demir M, et al. Can the mean platelet volume be a risk factor for vasculogenic erectile dysfunction? World J Mens Health. 2013;31(3):215–219. doi:10.5534/wjmh.2013.31.3.215
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- Ranjith MP, DivyaRaj R, Mathew D, George B, Krishnan MN. Mean platelet volume and cardiovascular outcomes in acute myocardial infarction. Heart Asia. 2016;8(1):16–20. doi:10.1136/heartasia-2015-010696
- Alper AT, Sevimli S, Hasdemir H, et al. Effects of high altitude and sea level on mean platelet volume and platelet count in patients with acute coronary syndrome. J Thromb Thrombolysis. 2009 Feb;27(2):130-4. Epub 2007 Nov 4.
- Al-Sweedan SA, Alhaj M. The effect of low altitude on blood count parameters. Hematol Oncol Stem Cell Ther. 2012;5(3):158-61. doi: 10.5144/1658-3876.2012.158.
- Joergensen MK, Bathum L. Reference intervals for mean platelet volume and immature platelet fraction determined on a sysmex XE5000 hematology analyzer. Scand J Clin Lab Invest. 2016;76(2):172-6. doi: 10.3109/00365513.2015.1124448. Epub 2016 Feb 6.
- Maluf CB, Barreto SM, Vidigal PG. Standardization and reference intervals of platelet volume indices: Insight from the Brazilian longitudinal study of adult health (ELSA-BRASIL). Platelets. 2015;26(5):413-20.doi:10.3109/09537104.2014.942620. Epub 2014 Aug 7.
- Panova-Noeva M, Schulz A, Hermanns MI, et al. Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study. Blood. 2016 Jan 14;127(2):251-9. doi: 10.1182/blood-2015-07-660308. Epub 2015 Oct 30.
Writer Bio
A registered nurse with more than 25 years of experience in oncology, labor/delivery, neonatal intensive care, infertility and ophthalmology, Sharon Perkins has also coauthored and edited numerous health books for the Wiley "Dummies" series. Perkins also has extensive experience working in home health with medically fragile pediatric patients.