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Premarin Vaginal Cream Side Effects

By Sarah Harding ; Updated August 14, 2017

According to Premarin.com, Premarin Vaginal Cream is a hormone therapy product that contains estrogen. It is often prescribed for women experiencing, the side effects of menopause, vaginal dryness and/or painful sex. The cream does more than just soothe the discomfort, like other vaginal lubricants. Premarin Vaginal Cream changes the vaginal tissues that provide elasticity and lubrication explains Premarinvaginalcream.com. When women experience menopause their estrogen levels drop, but the use of Premarin can help restore them enough to combat vaginal discomfort. The cream is available only by prescription and should be used at the lowest effective does for the shortest amount of time necessary. As with any medication, Premarin Vaginal Cream has the potential for side effects.

Serious Side Effects

Serious side effects may occur with the use of Premarin Vaginal Cream, but according to Drugs.com, these side effects were only reported in a small percentage of women studied. Stop taking the medication and report the side effects to your doctor right away if you experience any of the following: breast tissue changes; swelling of the stomach; swelling of the hands; swelling of the feet; swelling of the ankles; jaundice; chest pain; pain spreading to the arm or shoulder; nausea; sweating; migraine headache; confusion; or pain or tenderness in the abdomen.

The use of Premarin Vaginal Cream may increase the risk of some serious health issues. According to RxList.com, estrogen therapy has been linked to an increased risk of stroke, deep vein thrombosis (clotting), and hypertension. Women who use Premarin Vaginal Cream and have not had a hysterectomy are at an increased risk of developing endometrial cancer. Other serious health risks include breast cancer, dementia, gallbladder disease and visual abnormalities, according to RxList.com. These more serious health risks have not been specifically associated with the use of Premarin Vaginal Cream, but with the use of estrogen only and estrogen plus progestin therapy, explains RxList.com.

Less Serious Side Effects

Some side effects may occur frequently with the use of Premarin Vaginal Cream. If they become bothersome, discuss them with your doctor. Possible effects of using the cream include: headache; dizziness; fatigue; change in menstrual cycle; change in libido; vaginal irritation or discharge; mild nausea or vomiting; bloating; stomach cramps; breast tenderness, pain or swelling; darkening of the skin on the face; increase in freckles; weight changes; appetite changes; or increased hair growth or loss of hair. Premarinvaginalcream.com identifies the most commonly occurring side effects as abdominal pain, back pain, accidental injury, and vaginitis.

Allergic Reaction

Some individuals may be allergic to the ingredients in Premarin Vaginal Cream. A mild allergy may resemble some of the more moderate side effects of using the cream. According to Drugs.com, the following are side effects of a serious allergic reaction to Premarin Vaginal Cream: hives; difficulty breathing; and swelling of the face, lips, tongue, or throat. Individuals who experience these side effects should seek medical attention immediately.

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