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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- Cleveland Clinic: Testosterone Replacement Therapy
- MayoClinic.com: Testosterone Therapy: Key to Male Vitality?
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
What Are the Dangers of Testosterone Injections?
Testosterone is a male sex hormone and can be used to treat disorders such as hypogonadism, impotence and delayed puberty which is caused by a lack of this hormone, according to CIGNA.com 35. Replacement testosterone can be administered in several different formats; one way is through testosterone injections 135. A physician or nurse administers the injection every two to four weeks. Testosterone injections are associated with some adverse effects or dangers 35.
Worsening of Sleep Apnea
Sleep apnea is a sleep disorder in which the person stops breathing intermittently during the night. Testosterone injections can make this condition worse, according to MayoClinic.com 235. Sleep apnea can be dangerous and life-threatening; a physician needs to evaluate the patient for this condition.
Increased Red Blood Cells
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Testosterone injections can cause an increase a red blood cell counts in some patients 35. This can be problematic because the extra red blood cells can create an obstruction in a blood vessel and lead to a heart attack or stroke, according to the Palo Alto Medical Foundation 4.
Prostate Changes
Testosterone injections may also increase the size of the prostate gland 35. If a man already has benign prostate hypertrophy, which can cause problems with urination, testosterone injections can make this condition worse, according to the Palo Alto Medical Foundation 345. If a man has prostate cancer, he should not receive testosterone injections because the extra testosterone may cause the cancer to increase in size 35.
Enlarged Breasts
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Some men who receive testosterone injections may develop an increase in breast size 35. This danger typically only occurs in adult men who are being treated for hypogonadism and may persist in some patients, according to Drugs.com.
Testicular Changes
The testicles may become smaller in some men who receive testosterone injections 35. In younger men, the testicles may stop producing sperm or produce fewer sperm which decreases fertility. According to the Palo Alto Medical Foundation, problems with fertility typically resolve after stopping the testosterone injections 345.
Related Articles
References
- Cleveland Clinic: Testosterone Replacement Therapy
- MayoClinic.com: Testosterone Therapy: Key to Male Vitality?
- Drugs.com: Testosterone
- Palo Alto Medical Foundation: Testosterone Replacement Therapy
- CIGNA.com: Testosterone Injections
- Stanworth RD, Jones TH. Testosterone for the aging male; current evidence and recommended practice. Clin Interv Aging. 2008;3(1):25–44. doi:10.2147/cia.s190
- McBride JA, Carson CC 3rd, Coward RM. Testosterone deficiency in the aging male. Ther Adv Urol. 2016;8(1):47–60. doi:10.1177/1756287215612961
- Kumar P, Kumar N, Thakur DS, Patidar A. Male hypogonadism: Symptoms and treatment. J Adv Pharm Technol Res. 2010;1(3):297–301. doi:10.4103/0110-5558.72420
- Johnson JM, Nachtigall LB, Stern TA. The effect of testosterone levels on mood in men: a review. Psychosomatics. 2013;54(6):509-14.
- Rajfer J. Relationship between testosterone and erectile dysfunction. Rev Urol. 2000;2(2):122–128.
- Barrett-Connor E, Dam TT, Stone K, et al. The association of testosterone levels with overall sleep quality, sleep architecture, and sleep-disordered breathing. J Clin Endocrinol Metab. 2008;93(7):2602–2609. doi:10.1210/jc.2007-2622
- Beauchet O. Testosterone and cognitive function: current clinical evidence of a relationship. Eur J Endocrinol. 2006;155(6):773-81.
- Golds G, Houdek D, Arnason T. Male Hypogonadism and Osteoporosis: The Effects, Clinical Consequences, and Treatment of Testosterone Deficiency in Bone Health. Int J Endocrinol. 2017;2017:4602129. doi:10.1155/2017/4602129
- Grossmann M, Thomas MC, Panagiotopoulos S, et al. Low testosterone levels are common and associated with insulin resistance in men with diabetes. J Clin Endocrinol Metab. 2008;93(5):1834-40.
- Cai Z, Xi H, Pan Y, et al. Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet. Lipids Health Dis. 2015;14:18. Published 2015 Mar 7. doi:10.1186/s12944-015-0014-5
- Ferrucci L, Maggio M, Bandinelli S, et al. Low testosterone levels and the risk of anemia in older men and women. Arch Intern Med. 2006;166(13):1380–1388. doi:10.1001/archinte.166.13.1380
- Nassar GN, Leslie SW. Physiology, Testosterone. [Updated 2018 Oct 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526128/
- Rivas AM, Mulkey Z, Lado-Abeal J, Yarbrough S. Diagnosing and managing low serum testosterone. Proc (Bayl Univ Med Cent). 2014;27(4):321–324. doi:10.1080/08998280.2014.11929145
- Kanakis GA, Nieschlag E. Klinefelter syndrome: more than hypogonadism. Metab Clin Exp. 2018;86:135-144.
- Sizar O, Schwartz J. Hypogonadism. [Updated 2019 Jun 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532933/
- Nahata L, Yu RN, Bhasin S, Cohen LE. Management of testosterone therapy in adolescents and young men with hypogonadism: are we following adult clinical practice guidelines?. J Pediatr Endocrinol Metab. 2015;28(5-6):635-40.
- McBride JA, Carson CC, Coward RM. Diagnosis and management of testosterone deficiency. Asian J Androl. 2015;17(2):177–186. doi:10.4103/1008-682X.143317
- Crawford ED, Poage W, Nyhuis A, et al. Measurement of testosterone: how important is a morning blood draw?. Curr Med Res Opin. 2015;31(10):1911-4.
- Wersinger SR, Haisenleder DJ, Lubahn DB, Rissman EF. Steroid feedback on gonadotropin release and pituitary gonadotropin subunit mRNA in mice lacking a functional estrogen receptor alpha. Endocrine. 1999;11(2):137-43.
- Rhoden EL, Estrada C, Levine L, Morgentaler A. The value of pituitary magnetic resonance imaging in men with hypogonadism. J Urol. 2003;170(3):795-8.
- Snyder PJ, Kopperdahl DL, Stephens-Shields AJ, et al. Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone: A Controlled Clinical Trial [published correction appears in JAMA Intern Med. 2017 Apr 1;177(4):600] [published correction appears in JAMA Intern Med. 2019 Mar 1;179(3):457]. JAMA Intern Med. 2017;177(4):471–479. doi:10.1001/jamainternmed.2016.9539
- Huo S, Scialli AR, McGarvey S, et al. Treatment of Men for "Low Testosterone": A Systematic Review. PLoS One. 2016;11(9):e0162480. Published 2016 Sep 21. doi:10.1371/journal.pone.0162480
- Armamento-Villareal R, Aguirre LE, Qualls C, Villareal DT. Effect of Lifestyle Intervention on the Hormonal Profile of Frail, Obese Older Men. J Nutr Health Aging. 2016;20(3):334–340. doi:10.1007/s12603-016-0698-x
- American Urological Association. Evaluation and management of testosterone deficiency.
- Grech A, Breck J, Heidelbaugh J. Adverse effects of testosterone replacement therapy: an update on the evidence and controversy. Ther Adv Drug Saf. 2014;5(5):190–200. doi:10.1177/2042098614548680
- American Urological Association, Evaluation and Management of Testosterone Deficiency.
- Fillo J, Breza J Jr, Ondrusova M, Luha J, Ondrus D, Dubravicky J, et al. Results of long term testosterone replacement therapy in men with abdominal obesity, erectile dysfunction and testosterone deficiency. Bratisl Lek Listy. 2018;119(9):577-580. doi:10.4149/BLL_2018_061
- Tremellen K, McPhee N, Pearce K, Benson S, Schedlowski M, Engler H. Endotoxin-initiated inflammation reduces testosterone production in men of reproductive age. Am J Physiol Endocrinol Metab. 2018 Mar 1;314(3):E206-E213. doi:10.1152/ajpendo.00279.2017. Epub 2017 Nov 28.
Writer Bio
Dominique Brooks has been a medical editor for over 10 years. She has worked in medical education for physicians, nurses and pharmacists as well as consumers. She started writing business articles for Work.com in 2008 and health articles online in 2009. She holds a Master of Business Administration from the University of Alabama and a Doctor of Medicine from Vanderbilt University.