Flexamin is a dietary supplement formulated to support joint health. The active ingredients are glucosamine, chondroitin and methylsulfonylmethane, or MSM, a naturally occurring, organic derivative of sulfur. Together, these agents are reputed to improve joint function by providing the building blocks of cartilage. However, this product has not been proven effective and there may be side effects. If you have a chronic inflammatory condition that affects your joints, such as osteoarthritis, ask your doctor if this product is right for you.

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Product Description

Flexamin is made by Nature's Bounty, one of only 52 U.S. manufacturers accepted by the National Nutritional Foods Association. The company states that it is audited and certified by Shuster Laboratories, a third party, independent quality assurance and product testing facility. According to the manufacturer, Flexamin is formulated to enhance cartilage formation to support the muscles, bone and joints.


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Flexamin is available in four varieties: Extra Strength Complete, Triple Strength Joint Flex Formula, Triple Strength Bone Shield Formula and Super Glucosamine 2000 Plus. Each formula contains multiple ingredients reputed to support joint health, such as:

  • glucosamine HCl
  • chondroitin sulfate
  • vitamin K2
  • vitamin D3
  • hyaluronic acid
  • methylsulfonylmethane

Each formula also contains a proprietary mix of antioxidant compounds collectively registered under the trade name of Univestin.

Consumer Response

According to iGuard.org, a service that monitors the safety of prescription medications based on consumer polling and feedback, nearly 500 registered patients using Flexamin give a satisfaction rating of 5.7 and an effectiveness score of 5.9 on a scale of 1 to 10 1. In addition, 72 percent say the benefits of the drug outweigh any negative side effects, but 4 percent wish they knew more about the drug before taking it. However, keep in mind that this is a small sampling compared to the total number of patients using this product.


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According to the dietary supplements online database of the U.S. National Library of Medicine, Flexamin may cause an allergic reaction in certain people. In particular, if you have a known allergy to sulfur or shellfish, you should not use this product.

Drug Interactions

The U.S. National Library of Medicine says that you should not take this product if you are currently taking blood-thinning medications, such as warfarin or Coumadin. In addition, if you are on a regimen of daily aspirin therapy, you shouldn’t take this product due to an increased risk of bleeding.

Stomach Upset

This drug may cause gastrointestinal problems in some people. If you experience stomach pain or nausea, discontinue use and see your physician.

Safety in Pregnancy

Pregnant or nursing women should not use Flexamin. In addition, children under the age of 18 should not take this product.