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What Is the Difference Between B-12 & Methyl B-12?

Vitamin B-12 usually refers to cyanocobalamin, the most common form. Another form of B-12 is methylcobalamin, also called methyl B-12. B-12 is needed in the formation of DNA, nerves and red blood cells. It also helps the thyroid make hormones that regulate energy production and metabolism. B-12 supplements may be beneficial if deficiencies exist due to genetic factors, or lack of B-12 in the diet.

Methylcobalamin vs Cyanocobalamin

Methyl B-12 is more active in the body than cyanocobalamin. It helps regulate homocysteine levels. High homocysteine levels are indicated in stroke, kidney disease, dementia and Alzheimer's disease. In contrast, cyanocobalamin has no effect on homocysteine levels. Individuals with these conditions may benefit from methyl B-12 over cyanocobalamin. If a deficiency is present, your doctor will help determine the best form.


What Are the Different Types of B12?

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The National Institutes of Health indicate a recommended dietary intake of B-12 as 2.4 micrograms per day for adults and children 14 and older. Women pregnant or breastfeeding are recommended to get 2.8 micrograms daily. Infants younger than six months should have 0.4 micrograms per day. Those with a deficiency require higher amounts, sometimes up to 10,000 micrograms per day.


Adequate B-12 is usually acquired from food. Because cyanocobalamin is converted to methyl B-12 in the body, it may be unnecessary to supplement the methyl form of B-12. In rare cases, some individuals posses a biological inability to convert methyl B-12 from cyanocobalamin. In this case, a methyl B-12 supplement may help.


Is Methylcobalamin the Best Form of Vitamin B-12?

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The National Institutes of Health recognize B-12 as generally safe for most individuals. In rare cases, side effects can occur. These include, upset stomach, blood clots, diarrhea and allergic reactions. B-12 can interact with the antibiotic, chloramphenicol. In large doses, B-12 can reduce absorption of other B vitamins and vitamin C. Consult your doctor before supplementing either form of B-12.