Your body contains hundreds of hormones circulating within your blood or stored within various tissues of your body. Maintaining a proper level of each hormone proves important; too much or too little of a single hormone can lead to a hormonal imbalance. Vitamin D, an essential nutrient, plays a role in the production or biological activity of select hormones, and might therefore play a role in some types of hormone imbalances.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Effect on Parathyroid Hormones
Vitamin D in your body interacts with, and has an effect on the secretion of, hormones from your parathyroid glands. The glands -- located in your neck -- secretes parathyroid hormone, a signaling molecule that helps to regulate calcium in your body. The release of parathyroid hormone promotes the activation of vitamin D within your cells, which in turn leads to calcium regulation. A vitamin D deficiency can lead to the abnormal release of parathyroid hormone: since, in the absence of vitamin D, your body does not respond to parathyroid hormone, your hormone gland begins to produce very large amounts of the hormone to compensate. Over time, this can lead to a hormonal imbalance due to high levels of circulating parathyroid hormone.
- Vitamin D in your body interacts with, and has an effect on the secretion of, hormones from your parathyroid glands.
- The release of parathyroid hormone promotes the activation of vitamin D within your cells, which in turn leads to calcium regulation.
Effect on Pituitary
Vitamin C & Estrogen Level
A vitamin D deficiency can also have an effect on your pituitary gland, a small hormone in your brain that produces a range of hormones. One crucial aspect to regulating pituitary function is the control over pituitary cell growth; abnormal pituitary growth can lead to the development of tumors, which can in turn disrupt normal pituitary function and cause a hormonal imbalance. A study published in "Brain Pathology" in 2006 identifies vitamin D as important in regulating pituitary cell growth, and indicates that the vitamin might help to treat some pituitary tumors. As a result, vitamin D might help to prevent a pituitary hormonal imbalance in some cases.
- A vitamin D deficiency can also have an effect on your pituitary gland, a small hormone in your brain that produces a range of hormones.
- As a result, vitamin D might help to prevent a pituitary hormonal imbalance in some cases.
Vitamin D and Estrogen
In some cases, treatment with vitamin D supplements can help to relieve the symptoms associated with rapid changes in hormone levels. Hormonal imbalances cause by abnormally low estrogen production in a woman's body can occur as a side effect of some cancer treatments, surgeries, or can occur naturally as a result of menopause. This low estrogen can prove harmful, increasing the risk of osteoporosis.
Vitamins & Minerals for the Pituitary Gland
You can help to prevent some types of hormonal imbalances by avoiding a vitamin D deficiency. Moderate sun exposure -- sometimes as little as a few minutes in the sun between the hours of 10 a.m. and 2 p.m. -- allows your skin to make vitamin D to sustain your hormone levels. If you live in a high-latitude climate or receive little sun exposure, you may require additional vitamin D intake via fortified foods or dietary supplements. Talk to your doctor about an appropriate level of sun exposure for adequate vitamin D synthesis, and to discuss the possible benefit of vitamin D supplements.
- You can help to prevent some types of hormonal imbalances by avoiding a vitamin D deficiency.
- If you live in a high-latitude climate or receive little sun exposure, you may require additional vitamin D intake via fortified foods or dietary supplements.
Vitamin C & Estrogen Level
Vitamins & Minerals for the Pituitary Gland
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Vitamin B-12 & Serotonin
Signs & Symptoms of Low Vitamin B-12, Vitamin D & Iron
- Colorado State University; Parathyroid Hormone; R. Bowen; September 2003
- University of Maryland Medical Center; Possible Interactions with Vitamin D; Ernest B. Hawkins, MS, BSPharm, RPh; November 2007
- Holick MF, Gordon CM. Patient Guide to Vitamin D Deficiency. The Journal of Clinical Endocrinology & Metabolism. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a
- Sunyecz JA. The use of calcium and vitamin D in the management of osteoporosis. Ther Clin Risk Manag. 2008;4(4):827-836. doi:10.2147/tcrm.s3552
- Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168(11):1174-1180. doi:10.1001/archinte.168.11.1174
- Gorham ED, Garland CF, Garland FC, et al. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med. 2007;32(3):210-216. doi:10.1016/j.amepre.2006.11.004
- Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. The American Journal of Clinical Nutrition. 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586
- Prentice RL, Pettinger MB, Jackson RD, et al. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Osteoporos Int. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2
- Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91(5):1255-1260. doi:10.3945/ajcn.2009.29094
- Salehpour A, Hosseinpanah F, Shidfar F, et al. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. Nutr J. 2012;11:78. doi:10.1186/1475-2891-11-78
- Carrillo AE, Flynn MG, Pinkston C, et al. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. 2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014
- Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. Front Endocrinol. 2018;9:550. doi:10.3389/fendo.2018.00550
- Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(1):53-58. doi:10.1210/jc.2010-2704
- Bouillon R, Van Schoor NM, Gielen E, et al. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab. 2013;98(8):E1283-E1304. doi:10.1210/jc.2013-1195
- American Academy of Dermatology. Position Statement of Vitamin D. 2010.
- Taksler GB, Cutler DM, Giovannucci E, Keating NL. Vitamin D deficiency in minority populations. Public Health Nutr. 2015;18(3):379-391. doi:10.1017/S1368980014000457
- Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-1930. doi:10.1210/jc.2011-0385
- Cannell JJ, Vieth R, Umhau JC, et al. Epidemic Influenza and Vitamin D. Epidemiol Infect. 2006; 134:1129-40.
- Carrillo AE1, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of Vitamin D Supplementation During a Resistance Training Intervention on Body Composition, Muscle Function, and Glucose Tolerance in Overweight and Obese Adults. Clin Nutr. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. Epub 2012 Aug 31.
- Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009; 169:384-90.
- Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and Risk of Myocardial Infarction in Men: a Prospective Study. Arch Intern Med. 2008; 168:1174-80.
- Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. Am J Prev Med. 2007 Mar;32(3):210-6.
- Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9.
- Holick MF. Vitamin D. In: Shils M, Olson J, Shike M, Ross AC, ed. Modern Nutrition in Health and Disease, 9th ed. Baltimore: Williams and Wilkins, 1999.
- National Institutes of Health Office of Dietary Supplements. Vitamin D: Dietary Supplement Fact Sheet. University of Ottawa Evidence-based Practice Center. Effectiveness and Safety of Vitamin D in Relation to Bone Health. Agency for Healthcare Research and Quality. Aug 2007: 07-E013.
- Salehpour A1, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M. A 12-week Double-blind Randomized Clinical Trial of Vitamin D₃ Supplementation on Body Fat Mass in Healthy Overweight and Obese Women. Nutr J. 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78.
- Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. Am J Clin Nutr. 2010 91:1255-60. Epub 2010 Mar 10.
- Wilkins, Consuelo H. and Yvette I. Sheline, et al. “Vitamin D Deficiency Is Associated with Low Mood and Worse Cognitive Performance in Older Adults.” American Journal of Geriatric Psychiatry 14 (2006): 1032-40.
Sylvie Tremblay holds a Master of Science in molecular and cellular biology and has years of experience as a cancer researcher and neuroscientist. Based in Ontario, Canada, Tremblay is an experienced journalist and blogger specializing in nutrition, fitness, lifestyle, health and biotechnology, as well as real estate, agriculture and clean tech.