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Metformin, or Glucophage, is a drug given to diabetics to help them control their blood sugars. Like other prescription medications, Metformin can affect a person's sleep, and long-term users should be aware of one rare condition that causes extreme fatigue.

Is This an Emergency?

If you are experiencing serious medical symptoms, seek emergency treatment immediately.


Even diabetics who are not insulin dependent need to be wary of any symptoms that include severe fatigue, tiredness or drowsiness. This can be a sign of high blood sugar, the last step before a diabetic coma.

Drug Interactions

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Do not drink alcohol with Metformin. Mixing both substances can cause serious side effects on sugars, creating drowsiness and health problems.

Lactic acidosis is a rare condition that can occur when taking Metformin, and it may be signaled by severe drowsiness, chills and muscle pain. Although rare, this illness needs immediate attention, because it can be fatal.

Effect On Sleep

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Metformin itself may not cause sleep problems, but many conditions related to its use can trigger them because diabetics are prone to disorders like sleep apnea, obesity and insomnia. Hormonal conditions and peripheral neuropathy, with its nerve pain, also affects the ability to fall into restful sleep.

Sleep Hygiene

Practice good sleep hygiene, since even sleep apnea can bring on weight gain and affect sugar levels. This condition is linked to low leptin, an agent that helps in the metabolism of carbohydrates, leading the patient to crave more of them.

Additional Conditions

In rare cases outside of blood sugar, Metformin has caused nervousness, insomnia and other side effects related to sleep 1. A doctor should be alerted if any of these symptoms occur.