Side Effects of Losartan Potassium
There are a number of medicines on the market used to treat high blood pressure. Losartan, marketed under the brand, Cozaar, is one of those agents. It is a member of a class of drugs called angiotensin receptor blockers, also known medically as ARBs. They work by widening blood vessels, thus reducing the pressure or force of blood as it moves through the vessel. Losartan is also used to treat a kidney condition in people with diabetes called diabetic nephropathy.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Hypoglycemia
Losartan may cause hypoglycemia -- low glucose levels -- in patients with type 2 diabetes. It occurs more frequently in those diabetic patients being treated for diabetic nephropathy. A pre-marketing study involving 1,513 patients revealed 14 percent of the participants experienced hypoglycemia. This side effect did not result in the discontinuance of Losartan. Patients with diabetes, should closely monitor their glucose while taking this medication.
- Losartan may cause hypoglycemia -- low glucose levels -- in patients with type 2 diabetes.
- A pre-marketing study involving 1,513 patients revealed 14 percent of the participants experienced hypoglycemia.
Fatigue
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Losartan may cause fatigue 2. This side effect is commonly experienced by people being treated for diabetic nephropathy. In the RENAAL study -- a premarketing study -- 14 percent of the 1,513 participants reported feelings of fatigue. Patients taking Losartan for high blood pressure also report fatigue as a side effect. It occurs early in treatment and usually disappears with continued use.
- Losartan may cause fatigue 2.
- Patients taking Losartan for high blood pressure also report fatigue as a side effect.
Musculoskeletal Pain
Back pain, leg pain, muscle cramps and muscle weakness are possible side effects associated with the use of Losartan. Both people with high blood pressure and diabetic nephropathy have experienced one or more of these adverse reactions. However, the incidents are higher in those patients with diabetic kidney disease.
Dizziness
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Users of Losartan may also experience feelings of dizziness, especially those with high blood pressure. In a pre-marketing study involving 1,075 participants, 3 percent of the participants reported dizziness as a side effect. It usually occurs early in treatment or with an increase in dosage. But with continued use, the dizziness will eventually disappear.
- Users of Losartan may also experience feelings of dizziness, especially those with high blood pressure.
- But with continued use, the dizziness will eventually disappear.
Infections
Losartan may cause various types of infections. Some that have been reported among users, are respiratory infections like bronchitis, flu-like symptoms, throat infections and sinus infections. Some people may also experience urinary tract infections. Sixteen percent of the 1,513 participants of the RENAAL study reported experiencing a urinary tract infection.
- Losartan may cause various types of infections.
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References
- "Drug Information Handbook": Charles Lacy, RPh, Lora Armstrong, RPh., Morton Goldman, RPh. Leonard Lance, RPh.; 2008
- Epocrates Online: Losartan Monograph
- Merck and Company: Cozaar Monograph
- Society for Endocrinology. Angiotensin. Updated October 2019.
- American Heart Association. What is high blood pressure? 2020.
- MedlinePlus. Losartan. Updated February 15, 2018.
- Yeager A. Blood pressure meds point the way to possible COVID-19 treatment. TheScientist. April 2, 2020.
- University of Minnesota. Losartan for patients with COVID-19 requiring hospitalization. U.S. National Library of Medicine. ClinicalTrials.gov Identifier: NCT04312009. July 21, 2020.
- DailyMed. HYZAAR- losartan potassium and hydrochlorothiazide tablet, film coated. [Package insert.] Merck Sharp & Dohme Corp. Updated August 2020.
- U.S. Food and Drug Administration. COZAAR (losartan potassium) tablets, for oral use. [Package Insert]. Merck & Co., Inc. Updated October 2018.
- Helmer A, Slater N, Smithgall S. A review of ACE inhibitors and ARBs in Black patients with hypertension. Ann Pharmacother. 2018;52(11):1143-1151. doi:10.1177/1060028018779082
- U.S. Food and Drug Administration. Angiotensin receptor blockers (ARBs) information. Updated July 9, 2015.
- U.S. Food and Drug Administration. Recalls of angiotensin II receptor blockers (ARBs) including valsartan, losartan and irbesartan. Updated February 3, 2020.
Writer Bio
April Banks has been writing professionally since 2010. She is a pharmacist with more than 18 years of experience. Banks received a Bachelor of Science in pharmacy from the University of North Carolina at Chapel Hill and a Master of Public Health from the University of North Carolina at Greensboro. .