Which Medicines Affect PSA Levels?

PSA stands for prostate specific antigen. It is often used as a screening test to detect prostatic cancer. PSA levels can also be elevated due to a condition known as benign prostatic hypertrophy or due to certain activities, such as bicycle riding. Additionally, PSA levels can be affected by various medications.

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One medication that can affect PSA levels is finasteride, which goes by the brand name Proscar or Propecia. This medication can cause your PSA levels to be decreased.


Dutasteride, also called Avodart, is a medication for benign prostatic hyperplasia. It can result in lower than normal PSA levels.


Cyclophosphamide is an alkylating agent used to treat some kinds of cancers. High doses can alter PSA levels, causing them to be elevated.


Methotrexate is a chemical compound often used to suppress the immune system in order to treat certain cancers and for transplant patients. It can also lead to altered PSA levels 1.

Viagra and Cialis

Viagra and Cialis, while not directly affecting PSA levels, do promote sexual activity. Recent ejaculation (within 48 hours of the test) can cause PSA levels to be elevated.