Medications That Can Raise Calcium Levels in the Blood
Calcium is the most abundant mineral in the body and functions not only in the development and maintenance of bones and teeth but also in the health of nerves, muscles and the heart. Calcium deficiency can lead to serious health problems such as bone weakening, nerve damage and heart arrythmias. However, increased blood calcium levels, or hypercalcemia, may also cause health problems such as kidney stones or calcium crystal formation in the arteries and organs that can cause pain and dysfunction of the affected areas. Some medications may cause increased calcium levels in the blood.
Background
Vitamin D intake, through sunlight exposure or supplementation, aids in the absorption of calcium. Proper calcium intake can prevent or treat such conditions as hypothyroidism, high blood pressure and osteoporosis. It is excessive intake of calcium, above 2,500 to 3,000 mg daily, that may contribute to increased blood calcium levels that can cause a variety of health problems, according to the institute.
Medications That Increase Calcium
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In addition to excessive calcium intake, certain medications may increase blood calcium levels, such as:
- antacids
- lithium
- thiazide diuretics
- thyroxine
- vitamin D supplements
Parathyroid hormone regulates the level of calcium in the blood, the release of calcium from bone, absorption of calcium in the intestine and excretion of calcium in the urine. Increased secretion of the hormone can increase calcium levels in the blood.
Effects of Hypercalcemia
Normal blood calcium levels, according to Medline Plus, are between 8.5 and 10.2 milligrams per deciliter, with levels above that considered hypercalcemia 2. Hypercalcemia can lead to health problems such as renal insufficiency, vascular and soft tissue calcification, and kidney stones. The vascular calcification caused by hypercalcemia has been found to increase risk of coronary artery disease.
Considerations
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Hypercalcemia may be caused by a variety of health conditions other than excessive intake of calcium, vitamin D or certain medication usage, including Addison's disease, HIV/AIDS, hyperparathyroidism, metastatic bone tumors, overactive thyroid gland, Paget's disease or prolonged immobilization.cause:
- Hypercalcemia may be caused by a variety of health conditions other than excessive intake of calcium
- vitamin D or certain medication usage
- including Addison's disease
- HIV/AIDS
- hyperparathyroidism
- metastatic bone tumors
- overactive thyroid gland
- Paget's disease or prolonged immobilization
Therefore, before discontinuing use of any medication or modified diet due to a high calcium blood test, consult a health-care professional to determine the primary cause of your hypercalcemia and proper treatment 2.
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References
- Medline Plus: Calcium -- Blood Test
- National Institutes of Health Office of Dietary Supplements: Calcium
- Drugs.com: Levothyroxine Sodium
- Bolland, MJ, et. al. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ. 2011 Apr 19;342:d2040. DOI: 10.1136/bmj.d2040
- Reid IR. The roles of calcium and vitamin D in the prevention of osteoporosis. Endocrinol Metab Clin North Am. 27: 389-398. DOI:10.1016/s0889-8529(05)70011-6
- Chen M, Pan A, Malik VS, Hu FB. Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition. 2012;96(4):735-747. DOI:10.3945/ajcn.112.037119
- Williams V, Rawat A, Vignesh P, Shandilya JK, Gupta A, Singh S. Fc-gamma receptor expression profile in a North-Indian cohort of pediatric-onset systemic lupus erythematosus: An observational study. Int J Rheum Dis. 2019;22(3):449-457. doi: 10.6061/clinics/2012(07)22
- Reid IR, Birstow SM, Bolland MJ. Calcium and Cardiovascular Disease. Endocrinol Metab (Seoul). 2017;32(3):339-349. doi: 10.3803/EnM.2017.32.3.339
- MedlinePlus Medical Encyclopedia, "Milk-alkali syndrome"
- Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ. d2040-d2040. DOI:10.1136/bmj.d2040
- Chan Soo Shin, et. al. Endocrinol Metab (Seoul). 30(1): 27–34. DOI: 10.3803/EnM.2015.30.1.27
- Linus Pauling Institute. Calcium.
- National Institute of Health Office of Dietary Supplements. Calcium.
- Weingarten MAMA, Zalmanovici Trestioreanu A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD003548. DOI: 10.1002/14651858.CD003548.pub4
- Zemel, MB et. al. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res. 2004 Apr;12(4):582-90. DOI: 10.1038/oby.2004.67
Writer Bio
Originally from Maryland, Staci Gulbin started writing professionally in 2010. Her work has been published on a Baltimore news website as well as other online entities. Gulbin holds graduate degrees in biology and nutrition from New York University and Columbia University, and is a registered dietitian and certified personal trainer.