Percocet is the trade name for a prescription pain-relieving medicine, which contains the opiate drug oxycodone and the nonopiate drug acetaminophen 34. Percocet is widely prescribed in the U.S. for the management of moderate to moderately severe pain. The International Association for the Study of Pain reports roughly 31 percent of males and 40 percent of females suffer from chronic pain. People with addiction disorders may abuse Percocet; roughly 33 million Americans report having used pain relievers for nonmedical purposes.
Oxycodone Hydrochloride/Acetaminophen
Oxycodone hydrochloride is the generic name for the opiate pain reliever in Percocet. This narcotic drug is chemically similar to morphine and has been in use as a pain reliever since 1917. Although the exact mechanism of action is not fully understood, oxycodone and other narcotic pain relievers do not stop pain signals but rather alter the nervous system’s response to pain. The second pain-relieving drug in Percocet is acetaminophen, which is a non-narcotic pain reliever available in many over-the-counter products 34. Acetaminophen is believed to act by altering how the body senses pain 34. The co-administration of two pain relievers with different mechanisms of action is believed to provide superior pain relief than either drug would in isolation.
- Oxycodone hydrochloride is the generic name for the opiate pain reliever in Percocet.
Other Generic Names of Oxycodone Hydrochloride
List of Opiate Prescriptions
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Oxycodone hydrochloride is known by other non-trade names including oxycodone, oxycodone HCl, and dihydrohydroxycodeinone. Oxycodone is sometimes referred to simply as "oxy". The combination of any of these names followed by any of the generic names for acetaminophen may be used to refer to Percocet 34. Examples include oxy/APAP, oxycodone HCl/APAP and oxycodone HCl/acetaminophen 34.
Other Generic Names for Acetaminophen
Acetaminophen is known by other nontrade names including N-acetyl-p-aminophenol, APAP and its chemical name N-(4-hydroxyphenyl)acetamide 34. The combination of any of these names after any of the generic names for oxycodone hydrochloride may be used to refer to Percocet. Examples include oxycodone hydrochloride/APAP, oxycodone/APAP and oxycodone hydrochloride/N-acetyl-p-aminophenol.
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References
- Drugs.com: Percocet FDA monograph
- Medline Plus: Oxycodone
- Medline Plus: Acetaminophen
- Drugs.com: Acetaminophen
- National Institute on Drug Abuse. Treating Prescription Drug Addiction.
- National Institute on Drug Abuse. Research Report Series - Prescription Drugs: Abuse and Addiction.
- Abdel shaheed C, Maher CG, Williams KA, Day R, Mclachlan AJ. Efficacy, tolerability, and dose-dependent effects of opioid analgesics for low back pain: a systematic review and meta-analysis. JAMA Intern Med. 2016;176(7):958-68. doi:10.1001/jamainternmed.2016.1251
- U.S. National Library of Medicine, MedlinePlus. Oxycodone. Revised October 15, 2019.
- Cepeda MS, Fife D, Ma Q, Ryan PB. Comparison of the risks of opioid abuse or dependence between tapentadol and oxycodone: results from a cohort study. J Pain. 2013;14(10):1227-41. doi:10.1016/j.jpain.2013.05.010
- Darke S, Larney S, Farrell M. Yes, people can die from opiate withdrawal. Addiction. 2017;112(2):199-200. doi:10.1111/add.13512
- National Institute on Drug Abuse. Treating Prescription Drug Addiction.
- National Institute on Drug Abuse. Research Report Series - Prescription Drugs: Abuse and Addiction.
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Dr. Tina M. St. John owns and operates a health communications and consulting firm. She is also an accomplished medical writer and editor, and was formerly a senior medical officer with the U.S. Centers for Disease Control and Prevention. St. John holds an M.D. from Emory University School of Medicine.