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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- Acticlate - doxycycline hyclate tablet, coated. (2017).
- Doxycycline - doxycycline hyclate tablet, coated. (2017).
- Vibramycin monohydrate - doxycycline powder, for suspension; Vibramycin calcium - doxycycline calcium syrup; Vibramycin hyclate - Vibramycin hyclate capsule; Vibra-Tabs - doxycycline hyclate tablet, film coated. (2017).
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
Effects of Doxycycline on Periods
Doxycycline is a antibiotic that has a variety of side effects, which includes acid reflux and the possibility for an allergic reaction. It can also cause some other very serious side effects, such as permanent yellowing of teeth and, in infants or children, a sudden stoppage of bone growth. As with any antibiotic, the risks of side effects must be balanced with the advantages of using that particular antibiotic.
Doxycycline
Doxycycline is an antibiotic that is related to tetracycline 1. It can be used to treat a variety of infections, including bacterial and certain kinds of parasitic infections. It is often used to treat acne and diseases of the urinary tract and reproductive system. It can also be used prophylactically to prevent malaria.
- Doxycycline is an antibiotic that is related to tetracycline 1.
- It is often used to treat acne and diseases of the urinary tract and reproductive system.
Doxycycline and the Menstrual Cycle
Metronidazole for Acne Treatment
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Doxycycline is often anecdotally reported to interact with the menstrual cycle. Many women report that their period is delayed. This delay can last anywhere from a few days to several weeks. This delay is reported to occur both in women who are sexually active and those who aren't.
- Doxycycline is often anecdotally reported to interact with the menstrual cycle.
- This delay is reported to occur both in women who are sexually active and those who aren't.
Causes of Delayed Periods
The menstrual cycle is very sensitive to hormonal levels. These hormones can be affected by a variety of factors, including nutrition, stress and alterations in the circadian rhythm. While it is possible that doxycycline can interact with hormone levels, the conditions that often warrant doxycycline treatment (infection or malaria prophylaxis) can also lead to stress and dietary changes.
Doxycycline and Oral Contraceptives
Acidophilus & Gastritis
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Many doctors recommend that patients who are using oral contraceptives utilize another method of birth control while taking doxycycline. This is because doxycycline causes certain enzymes in the liver to become more activated. Because these enzymes also break down oral contraceptives, doxycycline treatment could compromise the effectiveness of these medications. Because oral contraceptives work by controlling hormone levels, any drug that interacts with them could disrupt the hormone cycle.
- Many doctors recommend that patients who are using oral contraceptives utilize another method of birth control while taking doxycycline.
- Because these enzymes also break down oral contraceptives, doxycycline treatment could compromise the effectiveness of these medications.
Significance
Clinical studies have determined that doxycycline does not decrease the effectiveness of oral contraceptives. Nevertheless, because of the medication's potential to disrupt the hormonal cycle, many physicians still recommend "backup" contraception for patients taking doxycycline.
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References
- Acticlate - doxycycline hyclate tablet, coated. (2017).
- Doryx - doxycycline hyclate tablet, delayed release. (2017). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=99cf2de6-e0a3-42f2-9929-d33e107af948
- Doryx MPC (doxycycline hyclate delayed-release tablets), for oral use. (2017).
- Doxycycline - doxycycline hyclate tablet, coated. (2017).
- Institute for Safe Medication Practices. (2016). Oral dosage forms that should not be crushed.
- Monodox doxycycline monohydrate capsules. (2017).
- Vibramycin monohydrate - doxycycline powder, for suspension; Vibramycin calcium - doxycycline calcium syrup; Vibramycin hyclate - Vibramycin hyclate capsule; Vibra-Tabs - doxycycline hyclate tablet, film coated. (2017).
- Del rosso JQ. Oral Doxycycline in the Management of Acne Vulgaris: Current Perspectives on Clinical Use and Recent Findings with a New Double-scored Small Tablet Formulation. J Clin Aesthet Dermatol. 2015;8(5):19-26.
- Cross R, Ling C, Day NP, Mcgready R, Paris DH. Revisiting doxycycline in pregnancy and early childhood--time to rebuild its reputation? Expert Opin Drug Saf. 2016;15(3):367-82. doi:10.1517/14740338.2016.1133584
- Velušček M, Bajrović FF, Strle F, Stupica D. Doxycycline-induced photosensitivity in patients treated for erythema migrans. BMC Infect Dis. 2018;18(1):365. doi:10.1186/s12879-018-3270-y
- Del Rosso JQ. "Oral Doxycycline in the Management of Acne Vulgaris: Current Perspectives on Clinical Use and Recent Findings with a New Double-scored Small Tablet Formulation." Journal of Clinical and Aesthetic Dermatology. 2015 May; 8(5): 19–26.
- Eichenfield LF, Krakowski AC, Piggott C, et al. "Evidence-based recommendations for the diagnosis and treatment of pediatric acne." Pediatrics. 2013;131(Suppl 3): S163–186.
- Titus S, Hodge J. “Diagnosis and Treatment of Acne.” American Family Physician. 2012 Oct 15;86(8):734-740.
- Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, et. al. "Guidelines of Care for the Management of Acne Vulgaris." Journal of the American Academy of Dermatology. 2016 May;74(5):945-73.e33.
Writer Bio
Adam Cloe has been published in various scientific journals, including the "Journal of Biochemistry." He is currently a pathology resident at the University of Chicago. Cloe holds a Bachelor of Arts in biochemistry from Boston University, a M.D. from the University of Chicago and a Ph.D. in pathology from the University of Chicago.