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Difference Between Lantus & Humalog

By Jeffrey Brian Airman ; Updated July 27, 2017

Lantus and Humalog are two different insulin medications that serve a similar purpose. Lantus slowly releases to regulate low levels of insulin while Humalog is a supplemental insulin taken with a meal to control a carbohydrate spike in diabetics.


Adults with type 2 diabetes and some children with type 1 diabetes require constant dosing of insulin to control sugar levels in the bloodstream. Lantus is intended to give users a 24-hour period of control, whereas Humalog is used to fill in the gaps, and effects diminish in the first hour.


Dosing for Lantus and Humalog is personalized to accommodate the blood sugar range of the individual. Both are taken by injection, with Lantus on a once a day schedule and Humalog taken at meals or as needed.

Side Effects

Humalog and Lantus have similar side effects that may include irritation at or around the injection site, and dangerously low blood sugar levels, also called hypoglycemia. Diabetics should consult with a medical professional if any serious side effects or allergic reactions persist.


The insulin in Lantus is slowly absorbed by the body in a steady stream over a 24-hour period, with the patient feeling little or no reaction. Humalog, on the other hand, is quickly absorbed with results being felt within the first fifteen minutes after taking, depending on doseage and body mass.


Lantus is taken once a day, usually in the morning, and left at home. Humalog is taken to supplement the release of insulin coming from a daily Lantus shot. Humalog is taken on a much more flexible, as-needed basis, as dictated by your day's schedule and mealtimes.

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