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How to Choose the Best Antidepressant for Weight Loss

By Contributor ; Updated July 27, 2017

Since weight gain can be a symptom of depression, many people want to choose the best antidepressant for weight loss. With the abundance of antidepressants available it can be difficult to choose the best antidepressant for weight loss. There are a few antidepressants that are known for helping people burn extra calories and helping people increase metabolism. If you are struggling with depression and weight gain, it's best to talk with a doctor who can prescribe an antidepressant medication that will help relieve anxiety and help with weight loss. To find the best antidepressant for weight loss, follow the tips below.

To lose weight with antidepressants, ask your doctor about bupropion. Many people have lost weight taking bupropion; however, the antidepressant may not be as effective as other medications for depression.

Ask your doctor about adderall (Dexedrine) for weight loss with antidepressants. Adderall used to be prescribed for weight loss, but now it's prescribed more for attention deficit disorder. Use caution with adderall because the medication is considered to be addictive.

Ask your doctor for an antidepressant that will increase your metabolism. Antidepressants like pramipexole and selegiline are dopaminergic antidepressants, which affect thyroid function by reducing prolactin. Low prolactin levels help increase thyroid hormones which in turn increase metabolism.

To decrease cravings, ask your doctor about reboxetine. Reboxetine helps people eat less because the antidepressants increase levels of norepinephrine. Norepinephrine helps reduce appetite. Reboxetine is available in several countries worldwide; however, it is not available in the United States.

If you are searching for the best antidepressants for weight loss, avoid SSRI antidepressants. SSRI medications like fluoxetine(Prozac), paroxetine, and Lexapro tend to cause weight gain. Paroxetine in particular has been reported to have a side effect of weight gain for many people.


When taking antidepressants for depression and weight loss, keep in mind that it's still important to exercise regularly and follow a healthy diet.


This article is for information purposes only and should not be used as medical advice.

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