Blood Plasma Functions
Plasma is the liquid portion of the blood. This slightly yellow fluid is made up of 90 percent water, according to the Franklin Institute. Although often thought of as less important than the cells of the blood that carry oxygen and provide immunity, the plasma is equally important. It is responsible for many different functions in the body.
Transport Nutrients
One of the most important functions of the plasma is to transport nutrients throughout the body. As food is digested in the stomach and intestines, it is broken down into its components. This includes amino acids (the building blocks of proteins), lipids (fats), sugars (glucose) and fatty acids. These nutrients are distributed to cells throughout the body where they are utilized to maintain healthy functions and growth.
- One of the most important functions of the plasma is to transport nutrients throughout the body.
- As food is digested in the stomach and intestines, it is broken down into its components.
Transport Waste
What Is the Most Abundant Electrolyte Found in Blood Plasma?
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In addition to transporting nutrients, the plasma transports waste products, such as:
- uric acid
- creatinine
- ammonium salts
- from the cells of the body to the kidneys
The kidneys filter these wastes out of the plasma and excrete them from the body as urine.
Maintain Blood Volume
Approximately 7 percent of the plasma is protein, according to the Science Encyclopedia 1. The protein found in the highest concentration in plasma is albumin, a protein important for tissue repair and growth. This high concentration of albumin is important for maintaining the osmotic pressure of the blood.
Albumin is also present in the fluids that surround the cells, known as the interstitial fluid. The concentration of albumin in this fluid is lower than in plasma. Because of this, water is not able to move from the interstitial fluid into the blood. If the plasma did not contain so much albumin, water would move into the blood, increasing blood volume and causing an increase in blood pressure which would make the heart work harder.
- Approximately 7 percent of the plasma is protein, according to the Science Encyclopedia 1.
- The protein found in the highest concentration in plasma is albumin, a protein important for tissue repair and growth.
Balance Electrolytes
What Proteins Are in Blood Plasma?
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Plasma carries salts, also called electrolytes, throughout the body. Without these salts, muscles would not contract and nerves would not be able to send signals to and from the brain.
Defend the Body
Plasma carries other proteins besides albumin throughout the body. Immunoglobulins, also known as antibodies, are proteins that fight off foreign substances, such as bacteria, that invade the body. Fibrinogen is a protein necessary to help the platelets (cells in the blood) to form blood clots. By carrying these proteins, the plasma is playing a critical role in defending the body against infection and blood loss.
- Plasma carries other proteins besides albumin throughout the body.
- Fibrinogen is a protein necessary to help the platelets (cells in the blood) to form blood clots.
Related Articles
References
- Science Encyclopedia: Blood Plasma
- Gondar Design Biology: Plasma
- Kaplan AA, Fridey JL. Therapeutic apheresis (plasma exchange or cytapheresis): Complications. UpToDate. March 2020.
- Kaplan AA, Fridey JL. Therapeutic Apheresis (Plasma Exchange or Cytapheresis): Complications. UpToDate. Updated August 2, 2018. https://www.uptodate.com/contents/therapeutic-apheresis-plasma-exchange-or-cytapheresis-complications.
- Olek MJ, Howard J. Treatment of Acute Exacerbations of Multiple Sclerosis in Adults. UpToDate. Updated October 9, 2018. https://www.uptodate.com/contents/treatment-of-acute-exacerbations-of-multiple-sclerosis-in-adults.
- Bobati SS, Naik KR. Therapeutic Plasma Exchange - An Emerging Treatment Modality in Patients with Neurologic and Non-Neurologic Diseases. J Clin Diagn Res. 2017;11(8):EC35-EC37. doi:10.7860/JCDR/2017/27073.10480
- ASFA.
- Cleveland Clinic. Plasmaphoresis in MS.
- Ehler J, Koball S, Sauer M, et al. Response to therapeutic plasma exchange as a rescue treatment in clinically isolated syndromes and acute worsening of multiple sclerosis: A retrospective analysis of 90 Patients. PLoS ONE. 2015;10(8):e0134583. doi:10.1371/journal.pone.0134583
- Schwartz J, Padmanabhan A, Aqui N, et al. Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the writing committee of the American Society for Apheresis: The seventh special issue. Journal of Clinical Apheresis. 2016;31(3):149-338. doi:10.1002/jca.21470
- USFDA. Coronavirus (COVID-19) update: Daily roundup, March 24, 2020. Updated March 24, 2020.
- Mount Sinai. Mount Sinai to begin the transfer of COVID-19 antibodies into critically ill patients. Updated March 24, 2020.
- Michigan State University. National COVID-19 Convalescent Plasma Project.
- USFDA. Recommendations for investigational COVID-19 convalescent plasma. Updated April 13, 2020.
- Szczepiorkowski ZM, Winters JL, Bandarenko N, et al. Guidelines on the use of therapeutic apheresis in clinical practice—Evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis. Journal of Clinical Apheresis. 2010;25:83-177. doi:10.1002/jca.20240
- Ehler J, Blechinger S, Rommer PS, et al. Treatment of the first acute relapse following therapeutic plasma exchange in formerly glucocorticosteroid-unresponsive Multiple Sclerosis patients-A nulticenter study to evaluate glucocorticosteroid responsiveness. Int J Mol Sci. 2017;18(8). doi:10.3390/ijms18081749
- Bobati SS, Naik KR. Therapeutic plasma exchange - An emerging treatment modality in patients with neurologic and non-neurologic diseases. J Clin Diagn Res. 2017;11(8):EC35-EC37. doi:10.7860/JCDR/2017/27073.10480
- UT Southwestern Medical Center. Therapeutic plasma exchange.
- Shemin D, Briggs D, Greenan M. Complications of therapeutic plasma exchange: a prospective study of 1,727 procedures. J Clin Apher. 2007;22(5):270-6. doi:10.1002/jca.20143
- Lu J, Zhang L, Xia C, Tao Y. Complications of therapeutic plasma exchange: A retrospective study of 1201 procedures in 435 children. Medicine (Baltimore). 2019;98(50):e18308. doi:10.1097/MD.0000000000018308
- Saint Luke's. Understanding therapeutic plasma exchange (TPE).
- Beth Israel Lahey Health Winchester Hospital. Plasmapheresis. Updated August 21, 2018.
- Szczeklik W, Wawrzycka K, Włudarczyk A, et al. Complications in patients treated with plasmapheresis in the intensive care unit. Anaesthesiol Intensive Ther. 2013;45(1):7-13. doi:10.5603/AIT.2013.0002
- Kaplan AA, Fridey JL. Therapeutic apheresis (plasma exchange or cytapheresis): Complications. March 2020.
- Harris ES, Meiselman HJ, Moriarty PM, Metzger A, Malkovsky M. Therapeutic plasma exchange for the treatment of systemic sclerosis: A comprehensive review and analysis. Journal of Scleroderma and Related Disorders. 2018;3(2):132-152. doi:10.1177/2397198318758606
- Ehler J, Blechinger S, Rommer PS, et al. Treatment of the First Acute Relapse Following Therapeutic Plasma Exchange in Formerly Glucocorticosteroid-Unresponsive Multiple Sclerosis Patients-A Multicenter Study to Evaluate Glucocorticosteroid Responsiveness. International Journal of Molecular Sciences. 2017;18(8):1749. Published 2017 Aug 11. doi:10.3390/ijms18081749.
- Harris ES, Meiselman HJ, Moriarty PM, Metzger A, Malkovsky M. Therapeutic Plasma Exchange for the Treatment of Systemic Sclerosis: A Comprehensive Review and Analysis. Journal of Scleroderma and Related Disorders. 2018;3(2):132–152. doi:10.1177/2397198318758606.
- Kaplan AA, Fridey JL. Therapeutic Apheresis (Plasma Exchange or Cytapheresis): Complications. Updated August 2, 2018.
- Olek MJ, Howard J. Treatment of Acute Exacerbations of Multiple Sclerosis in Adults. Updated October 9, 2018.
- Panayiota P, Ben-Hur T, Adi Vaknin D, Oded A, Dimitrios K. Clinical Efficacy of Plasma-Exchange in Patients With Progressive Forms of Multiple Sclerosis and NMO-Spectrum Disease. Journal of Multiple Sclerosis. 2016;3:181. doi:10.4172/2376-0389.1000181.
- Schwartz J, Padmanabhan A, Aqui N, et al. Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Seventh Special Issue. Journal of Clinical Apheresis. 2016;31(3):149–62. doi:10.1002/jca.21470.
Writer Bio
Stephanie Chandler is a freelance writer whose master's degree in biomedical science and over 15 years experience in the scientific and pharmaceutical professions provide her with the knowledge to contribute to health topics. Chandler has been writing for corporations and small businesses since 1991. In addition to writing scientific papers and procedures, her articles are published on Overstock.com and other websites.