Alpha-Lipoic Acid Side Effects
The fatty acid alpha-lipoic acid is found naturally in foods such as broccoli, liver, potatoes and spinach. Now available as an antioxidant supplement, you can take alpha-lipoic acid to protect your cell walls from oxidation damage by free radicals, which may help limit your risk of developing cancer. Because the U.S. Food and Drug Administration does not regulate alpha-lipoic acid supplements, you cannot be certain that dosages and ingredients stated on labels are accurate. Consult your doctor about alpha-lipoic acid before you take this supplement.
Tiredness
When you first begin using alpha-lipoic acid, you may begin to feel more tired than usual, Drugs.com warns. This tiredness or fatigue may be because this supplement can decrease your blood sugar levels. Tiredness associated with alpha-lipoic acid supplements typically ceases as you get accustomed to it. Speak with a physician, however, if fatigue persists.
- When you first begin using alpha-lipoic acid, you may begin to feel more tired than usual, Drugs.com warns.
- Tiredness associated with alpha-lipoic acid supplements typically ceases as you get accustomed to it.
Gastric Disturbances
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You may experience stomach upset when you begin taking alpha-lipoic acid. In most cases, this stomach upset will dissipate with further use of the supplement. You may be able to avoid stomach upset by taking this supplement with food.
Pain
Higher levels of alpha-lipoic acid may cause cramps, also known as spasms, to occur in your muscles. This generally happens with initial use of the supplement and usually stops as your body grows used to it. You should not feel severe cramps as a side effect of alpha-lipoic acid, but if you do, seek medical counsel.
Hypoglycemia
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Hypoglycemia is the condition in which glucose levels are too low in your blood. Also known as low blood sugar, hypoglycemia can be a serious problem. You can eat something quickly to help raise your blood sugar levels, but seek medical assistance if you continue to experience symptoms such as feeling faint, a rapid heartbeat, irritability, blurry vision or hunger. Hypoglycemia may cause problems such as confusion and problems concentrating. Low blood sugar is especially dangerous for people who have prediabetes or diabetes. If you have these conditions, or any other preexisting health condition, do not use these supplements without first consulting your doctor.
- Hypoglycemia is the condition in which glucose levels are too low in your blood.
- Low blood sugar is especially dangerous for people who have prediabetes or diabetes.
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References
- National Cancer Institute; Antioxidants and Cancer Prevention; July 2004
- Memorial Sloan-Kettering Cancer Center; Alpha-Lipoic Acid; January 2011
- Drugs.com; Alpha-Lipoic Acid; March 2011
- University of Maryland Medical Center; Alpha-Lipoic Acid; March 2009
- Gomes MB, Negrato CA. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetol Metab Syndr. 2014;6(1):80. doi:10.1186/1758-5996-6-80
- Akbari M, Ostadmohammadi V, Lankarani KB, et al. The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Metab Clin Exp. 2018;87:56-69. doi:10.1016/j.metabol.2018.07.002
- Zhang Y, Han P, Wu N, et al. Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects. Obesity (Silver Spring). 2011;19(8):1647-53. doi:10.1038/oby.2011.121
- Mijnhout GS, Kollen BJ, Alkhalaf A, Kleefstra N, Bilo HJ. Alpha lipoic acid for symptomatic peripheral neuropathy in patients with diabetes: a meta-analysis of randomized controlled trials. Int J Endocrinol. 2012;2012:456279. doi:10.1155/2012/456279
- Kucukgoncu S, Zhou E, Lucas KB, Tek C. Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. Obes Rev. 2017;18(5):594-601. doi:10.1111/obr.12528
- Koh EH, Lee WJ, Lee SA, et al. Effects of alpha-lipoic Acid on body weight in obese subjects. Am J Med. 2011;124(1):85.e1-8. doi:10.1016/j.amjmed.2010.08.005
- Pagano C, Calarco P, et. al. Development and characterization of new topical hydrogels based on alpha lipoic acid—hydrotalcite hybrids. Cosmetics 2019;6(2), doi:10.3390/cosmetics6020035
- Tolunay O, Çelik T, Kömür M, Gezgin AE, Kaya MS, Çelik Ü. A rare cause of status epilepticus; alpha lipoic acid intoxication, case report and review of the literature. Eur J Paediatr Neurol. 2015;19(6):730-2. doi:10.1016/j.ejpn.2015.07.002
- Bao Y, Gao C, Hao W, et al. Effects of dietary L-carnosine and alpha-lipoic acid on growth oerformance, blood thyroid hormones and lipid profiles in finishing pigs. Asian-Australas J Anim Sci. 2015;28(10):1465-70. doi:10.5713/ajas.14.0604
- Han T, Bai J, Liu W, Hu Y. A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. Eur J Endocrinol. 2012;167(4):465-71. doi:10.1530/EJE-12-0555
Writer Bio
Carole Anne Tomlinson is a registered nurse with experience in rehabilitation, nutrition, chemical dependency, diabetes and health problems related to the elderly. Tomlinson holds a Bachelor of Arts in criminal justice and is presently working on her master's degree in nursing. Her screenplays have been viewed by Merchant Ivory, Angela Lansbury and Steven King's associates.