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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- MedlinePlus: L-Arginine
- Amino Acids: Beneficial Effects of L-Arginine on Reducing Obesity: Potential Mechanisms and Important Implications for Human Health
- Amino Acids: Beneficial Effects of L-Arginine on Reducing Obesity: Potential Mechanisms and Important Implications for Human Health
- Journal of the International Society of Sports Nutrition: International Society of Sports Nutrition Position Stand: Protein and Exercise
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
Can I Take Whey Protein & Arginine Together?
Arginine, or l-arginine, is an amino acid naturally occurring in meats, fish and dairy 2. You can also take arginine supplements for conditions such as post-surgical recovery, hypertension and preeclampsia. Because arginine helps your body make protein and may increase blood flow to muscle fibers by raising nitric oxide levels, bodybuilders often consume l-arginine prior to workouts 2. Active strength-training enthusiasts may also take whey protein supplements to facilitate recovery and muscle growth. Whey and arginine don't have any harmful interactions, so they can be together. However, arginine has the potential to cause side effects in some people, so you should check with your doctor before taking it.
Signficance
If you take the trouble and expense of adding whey or arginine to your workout nutrition regimen you want their effects to be maximized. Taking whey protein around the time of your strength-training workout can help enhance your ability to build lean muscle mass, notes the International Society of Sports Nutrition 4. Consuming 3 to 5 grams of arginine prior to a workout may further increase muscle gain. Arginine's ability to increase blood flow and nitric oxide helps facilitate the delivery of oxygen, other amino acids, testosterone and growth hormone to your muscles, notes Dwayne Jackson, PhD, and Jim Stoppani, PhD, in "Muscle and Fitness." A study in the 2010 issue of “Amino Acids” notes that l-arginine holds great promise in being able to reduce body fat while increasing lean muscle mass and improving the metabolism of humans and animals 2.
Arginine and Whey
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Arginine has no known food interactions. In fact, most whey protein formulas contain arginine. The National Institutes of Health notes that arginine can cause an interaction when taken with xylitol, a sugar alcohol sometimes included in whey protein supplement drinks and bars. Arginine helps the body release a hormone known as glucagon which can help prevent your blood sugar from dropping to very low levels. Xylitol taken with arginine can inhibit the production of glucagon, which means you may run out of energy during exercise. It could also lead to symptoms including dizziness and weakness, which prevents maximum lifts and muscle growth.
- Arginine has no known food interactions.
- Xylitol taken with arginine can inhibit the production of glucagon, which means you may run out of energy during exercise.
Timing
You should take arginine prior to a strength-training workout because it can increase the availability of the hormones and amino acids you need during your workout, recommend Stoppani and Jackson. You may take a serving of whey prior to a workout as well so your body has access to the branched-chain amino acids, leucine, isoleucine and valine, that stimulate muscle protein synthesis as soon as your muscles start to break down during heavy lifting, as noted by the International Society of Sports Nutrition 4. Whey protein may also be taken immediately after a strength-training session to facilitate recovery.
Considerations
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Arginine can pose some dangers, whether or not it is taken with whey. Do not take l-arginine supplements if you are on high blood pressure medications – it could lower your blood pressure to dangerous levels 2. You should avoid arginine if you are pregnant or breast feeding. In sensitive people, arginine can cause an allergic reaction. If you suffer from herpes, arginine may cause the virus to multiply faster than usual. You should also avoid arginine if you recently had a heart attack, as it could increase your risk of death.
- Arginine can pose some dangers, whether or not it is taken with whey.
- Do not take l-arginine supplements if you are on high blood pressure medications – it could lower your blood pressure to dangerous levels 2.
Related Articles
References
- NYU Langone Medical Center: Arginine
- MedlinePlus: L-Arginine
- Amino Acids: Beneficial Effects of L-Arginine on Reducing Obesity: Potential Mechanisms and Important Implications for Human Health
- Journal of the International Society of Sports Nutrition: International Society of Sports Nutrition Position Stand: Protein and Exercise
- Rajapakse NW, Mattson DL. Role of L-arginine in nitric oxide production in health and hypertension. Clin Exp Pharmacol Physiol. 2009;36(3):249-55. doi:10.1111/j.1440-1681.2008.05123.x
- Patel A, Layne S, Watts D, Kirchner KA. L-arginine administration normalizes pressure natriuresis in hypertensive Dahl rats. Hypertension. 1993;22(6):863-9. doi:10.1161/01.hyp.22.6.863
- Neurohormonal Activation in the Treatment of Congestive Heart Failure: Basis for New Treatments? Cardiology. 1998 Jul;90(1):1-7. Review.
- Altun ZS, Uysal S, Guner G, Yilmaz O, Posaci C. Effects of oral L-arginine Supplementation on Blood Pressure and Asymmetric Dimethylarginine in Stress-Induced Preeclamptic Rats. Cell Biochem Funct. 2008 Jun 2.
- Watanabe M, Ishikawa Y, Campbell W, Okada H. Measurement of Arginine Carboxypeptidase-Generating Activity of Adult Plasma. Microbiol Immunol. 1998;42(5):393-7.
Writer Bio
Andrea Boldt has been in the fitness industry for more than 20 years. A personal trainer, run coach, group fitness instructor and master yoga teacher, she also holds certifications in holistic and fitness nutrition.