Overextending a joint or muscle can cause damage -- sprains or strains -- in the tendons, ligaments and muscles that support a joint 1. Injuries to tendons and ligaments require longer periods of time to heal that similar injuries to muscles. Supplementing with the amino acid L-glutamine can help speed the recovery process. Follow your doctor's guidelines in treating and rehabilitating sprained tendons.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Tearing of the tendon tissue underlies all sprains 1. Sprains are classified into three grades according to severity: first degree with minor tears, second degree with moderate to severe tears and third degree with a complete tear. Symptoms of sprains include swelling, pain and tenderness. Second- and third-degree sprains can cause severely decreased range of motion and joint instability.
- Tearing of the tendon tissue underlies all sprains 1.
- Second- and third-degree sprains can cause severely decreased range of motion and joint instability.
Degrees of Ankle Sprain
Mild first-degree sprains normally can be treated using the RICE method: rest, ice, compression and elevation. More severe sprains also may require immobilization as they begin to heal. Severe sprains and strains may require surgical repair of the tendon or ligament 12. Moderate to severe sprains should be treated under a physician's supervision. Your doctor may recommend prescription or over-the-counter analgesic and anti-inflammatory medication.
- Mild first-degree sprains normally can be treated using the RICE method: rest, ice, compression and elevation.
- More severe sprains also may require immobilization as they begin to heal.
L-glutamine is the most abundant amino acid in your body. L-glutamine is nonessential, meaning your body can produce sufficient amounts under normal conditions. Extreme physical activity, stress, surgery, prolonged illness or a low-protein diet can contribute to decreased glutamine levels. Amino acids, such as L-glutamine, are required to produce structural proteins to repair injuries such as strains and sprains.
- L-glutamine is the most abundant amino acid in your body.
- L-glutamine is nonessential, meaning your body can produce sufficient amounts under normal conditions.
How it Helps
Glutamine Powder or Capsules
Glutamine can help strengthen the immune system, prevent infections and lower stress hormone levels, according to the University of Maryland Medical Center 3. Adequate dietary protein levels are required for proper wound healing. Studies reported in "Alternative Medicine Review" have shown the amino acids L-glutamine and L-arginine assist with wound healing above the effects of having sufficient dietary protein. L-glutamine and L-arginine are known to be abundant in muscles and tendons and play important roles in the immune system as well.
- Glutamine can help strengthen the immune system, prevent infections and lower stress hormone levels, according to the University of Maryland Medical Center 3.
- Studies reported in "Alternative Medicine Review" have shown the amino acids L-glutamine and L-arginine assist with wound healing above the effects of having sufficient dietary protein.
L-glutamine occurs naturally in your body and does not, itself, have any side effects. However, glutamine supplements may contain allergens or other impurities. Consult with your doctor before beginning supplementation. Supplemental L-glutamine is safe in doses of up to 14 grams per day, according to the University of Maryland Medical Center, although results may be seen with as little as 500 mg 3. Consult with your doctor to determine the best dose for you based on your injury, overall health and diet. Do not take L-glutamine with hot beverages or food, as heat denatures the amino acid.
- L-glutamine occurs naturally in your body and does not, itself, have any side effects.
Degrees of Ankle Sprain
Glutamine Powder or Capsules
Vitamins for Tendinitis
How Long Does It Take to Heal a Second Degree Burn?
Do GABA Supplements Have Side Effects?
Pineapple Enzymes for Healing Torn Ligaments and Bones
4 Treatments for a Torn Shoulder Ligament
What Are the Treatments for High Cortisol?
Torn Tendons & Ligaments From Hyperextension
Vitamin B-6 & Tendonitis
- The Merck Manual: Sprains, Strains and Tendon Tears
- American Academy of Orthopaedic Surgeons: Sprains, Strains and Other Soft-Tissue Injuries
- University of Maryland Medical Center: Glutamine
- Gleeson M. Dosing and efficacy of glutamine supplementation in human exercise and sport training. J Nutr. 2008;138(10):2045S-2049S. doi:10.1093/jn/138.10.2045S
- Barnabé N, Butler M. The effect of glucose and glutamine on the intracellular nucleotide pool and oxygen uptake rate of a murine hybridoma. Cytotechnology. 2000;34(1-2):47-57.
- Cruzat V, Macedo rogero M, Noel keane K, Curi R, Newsholme P. Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients. 2018;10(11). doi:10.3390/nu10111564
- Kim MH, Kim H. The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. Int J Mol Sci. 2017;18(5). doi:10.3390/ijms18051051
- Gaurav K, Goel RK, Shukla M, Pandey M. Glutamine: A novel approach to chemotherapy-induced toxicity. Indian J Med Paediatr Oncol. 2012;33(1):13-20. doi:10.4103/0971-5851.96962
- Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev. 1999;4(4):239-48.
- Peng X, Wang SL. Glutamine and immunonutrition for burn patients. Zhonghua Shao Shang Za Zhi. 2009;25(5):321-4.
- Dos santos GG, Hastreiter AA, Sartori T, Borelli P, Fock RA. L-Glutamine in vitro Modulates some Immunomodulatory Properties of Bone Marrow Mesenchymal Stem Cells. Stem Cell Rev Rep. 2017;13(4):482-490. doi:10.1007/s12015-017-9746-0
- Holecek M. Side effects of long-term glutamine supplementation. JPEN J Parenter Enteral Nutr. 2013;37(5):607-16. doi:10.1177/0148607112460682
- Barker-haliski M, White HS. Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harb Perspect Med. 2015;5(8):a022863. doi:10.1101/cshperspect.a022863
- Lenders CM, Liu S, Wilmore DW, et al. Evaluation of a novel food composition database that includes glutamine and other amino acids derived from gene sequencing data. Eur J Clin Nutr. 2009;63(12):1433-9. doi:10.1038/ejcn.2009.110
- Gleeson M. Dosing and efficacy of glutamine supplementation in human exercise and sports training. J Nutr. 2008 Oct;138(10):2045S-2049S. DOI: 10.1093/jn/138.10.2045S.
- Haub, H.; Potteiger, J.; Nau, K. et al. Acute L-glutamine ingestion does not improve maximal effort exercise. J Sports Med Phys Fitness. 1998 Sep;38(3):240-4. DOI:
- Lopez-Vaquero, D.; Gutierrez-Bayard, L.; Rodriguez-Ruiz, J. et al. Double-blind randomized study of oral glutamine on the management of radio/chemotherapy-induced mucositis and dermatitis in head and neck cancer. Mol Clin Oncol. 2017 Jun;6(6):931-36. DOI: 10.3892/mco.2017.1238.
- Oguz, M.; Kerem, M.; Bedirli, A. et al. L-alanin-L-glutamine supplementation improves the outcome after colorectal surgery for cancer. Colorectal Dis. 2007 Jul;9(6):515-20. DOI: 10.1111/j.1463-1318.2006.01174.x.
- Pattanshetti, V.; Powar, R.; Godhi, A. et al. Enteral glutamine supplementation reducing infectious morbidity in burns patients: a randomised controlled trial. Indian J Surg. 2009 Aug;71(4):193-7. DOI: 10.1007/s12262-009-0056-x.
Chris Daniels covers advances in nutrition and fitness online. Daniels has numerous certifications and degrees covering human health, nutritional requirements and sports performance. An avid cyclist, weightlifter and swimmer, Daniels has experienced the journey of fitness in the role of both an athlete and coach.