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Does Drinking Grapefruit Juice Make Lortab Hit You Faster?

By Joseph McAllister

Lortab, a narcotic pain medication that contains both acetaminophen and hydrocodone, may sometimes be absorbed faster when you drink grapefruit juice. However, grapefruit juice is usually not likely to interact with Lortab; it is more likely to interact with medications prescribed for heart problems. Discuss drug interactions with your doctor.

Grapefruit Juice and Medication

Grapefruit juice can sometimes interact with certain medications, because it can change some of the reactions of enzymes in your digestive tract, notes the American Pharmacists Association. This can make the medicine enter your system more quickly, making you more likely to experience the medication’s side effects. Not all medications are affected by grapefruit juice, and other juices do not generally interact with medicines. Grapefruit juice can interact with your medications for up to three days after you drink it.

Grapefruit Juice and Lortab

Neither of Lortab’s two components, acetaminophen and hydrocodone, are considered to be medications that generally interact with grapefruit juice. Grapefruit juice typically interacts with drugs used to treat high cholesterol, high blood pressure and heart arrhythmias, particularly statins and calcium channel blockers. However, in some individuals, grapefruit might interact with Lortab, so talk to a pharmacist or doctor to make sure that grapefruit juice is safe for you. If the juice makes you absorb Lortab faster, you will be more likely to feel side effects from the medication.

Side Effects

If your body does absorb Lortab more quickly because you drank grapefruit juice, you are more likely to suffer from side effects like anxiety, dizziness, nausea and headaches. Less serious side effects also include blurred vision, drowsiness, constipation and dry mouth. If you have an allergic reaction, with symptoms like hives or swelling of your face, throat and tongue, immediately seek medical help. If you experience more serious side effects, like fainting, seizures or jaundice, call your doctor right away.

Interactions with Lortab

Lortab can affect your alertness, so be cautious when driving or doing anything that requires you to concentrate, and do not drink alcohol, which can further slow your reactions. You are more likely to sustain liver damage if you drink alcohol while taking medications with acetaminophen, notes Lortab can also interact with medications like antidepressants, other pain medications, bladder medications, bronchodilators and other narcotics. Consult your pharmacist or physician before taking cold, allergy or sleep medications.

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