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Lysine & Adderall

By Allen Bethea

Lysine and Adderall differ in their chemical composition and in the role they play in your health. Lysine is a natural substance found in the foods you eat. Adderall is mixture of man-made chemicals that mimic the action of natural neurotransmitters. There is a possibility of adverse reactions anytime you take a prescription drug with another biologically active chemical compound. It is important to always consult with your physician before you take over-the-counter drugs or dietary supplements containing lysine along with prescribed medications.


Lysine is one of 22 amino acids your body uses to produce proteins. Lysine also assists in the development and health of bone, collagen and skin tissue. Your body can synthesize sufficient amounts of some amino acids to meet its needs, but lysine is one of 11 essential amino acids that can only come from your diet or from dietary supplements. According to the University of Maryland Medical Center website, lysine deficiency symptoms include fatigue, nausea, dizziness, loss of appetite, agitation, bloodshot eyes, slow growth, anemia and reproductive disorders.


Adderall is a prescription drug used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. A single Adderall tablet contains equal amounts of four different amphetamine chemical entities: dextroamphetamine saccharate, dextroamphetamine sulfate USP, amphetamine sulfate USP and amphetamine aspartate monohydrate. Adderall is a U.S. Drug Enforcement Agency Class II substance because of its addictiveness and high abuse potential.

Adderall and Lysine Warnings

According to a medication guide published on the Food and Drug Administration website, serious Adderall side effects include sudden death in patients, heart disease, stroke, heart attacks and elevated blood pressure. Adderall may also adversely affect your behavior. It can cause or worsen bipolar illness. It may also may trigger aggression, hostility and other behavioral problems. Other side effects include slowed growth in children, visual problems, headache, decreased appetite, nervousness, trouble sleeping, mood swings and weight loss.

In one form or another, lysine is present in every cell of your body. Lysine supplements are generally safe – even in doses up to 3 grams per day. According to a monograph published in the "Alternative Medicine Review," however, doses greater than 10 grams per day can cause upset stomach, nausea, abdominal cramps and diarrhea. In addition, high doses of lysine may cause gallstones and adversely affect kidney function.

Drug Interactions

According to, there are no drug interactions between lysine and Adderall. A 2009 monograph provided by the manufacturer Shire Canada Inc. also lists no drug interactions or warnings of adverse reactions caused by taking lysine along with Adderall. Lisdexamfetamine -- another prescription treatment for ADHD -- may provide proof that there is no adverse drug interaction between lysine and Adderall. Lisdexamfetamine is manufactured by chemically joining a lysine molecule to a molecule of d-amphetamine -- an ingredient in Adderall. Once in the stomach, the Lisdexamfetamine molecule splits up into d-amphetamine and lysine again.

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