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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- National Institutes of Health: Office of Dietary Supplements: Zinc
- Linus Pauling Institute; Phytosterols; Jane Higdon, Ph.D.; Sept. 2008
- Medline Plus; Enlarged Prostate; aug. 10, 2009
- Linus Pauling Institute: Zinc and Prostate Cancer: Emily Ho, PhD and Michelle Yan; May 2005
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Zinc & an Enlarged Prostate
Staying healthy as you age is a priority for many Americans, yet your body undergoes changes that are often beyond your control. Hormonal shifts in mid-life bring on unwelcome discomforts for both men and women. For men, one of the most bothersome of these age-related changes is an enlarged prostate.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Enlarged Prostate
An enlarged prostate, known clinically as benign prostatic hyperplasia, or BPH, is non-cancerous growth of the male prostate gland that occurs in almost all men as they grow older. The prostate is a reproductive gland that produces the fluid that carries sperm during ejaculation. Because the prostate surrounds the urethra, the tube that carries urine out of the body, an enlarged prostate puts pressure on the urethra, making urinating difficult and sometimes leading to bladder problems.
Zinc Properties and Dosage
Can Zinc & Saw Palmetto Shrink the Prostate Gland?
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Many nutrients have been examined for potential properties that might ease the symptoms of BPH. Zinc is an essential trace mineral that is present in many proteins and plays a role in immune response and cell growth. Zinc is of interest as a treatment for BPH because it is present in significant amounts in prostate cells, where it appears to play a protective and anti-inflammatory role. While zinc supplementation may seem a logical treatment for BPH, the Linus Pauling Institute cautions that excessively high doses of zinc greater than 100 mg may increase the risk of prostate cancer 5. The United States Institute of Medicine currently sets the upper limits for zinc supplementation at 40 mg. Dietary zinc is found in large quantities in oysters and red meats.
- Many nutrients have been examined for potential properties that might ease the symptoms of BPH.
- Zinc is of interest as a treatment for BPH because it is present in significant amounts in prostate cells, where it appears to play a protective and anti-inflammatory role.
Zinc and Enlarged Prostate
In a 2007 study, Oregon State University researchers examined the role of zinc in the DNA damage response of prostate cells. The study led the research team to conclude that zinc deficiency may impair the function of zinc-containing proteins in the prostate leading to abnormalities in prostate function and growth, and increasing the risk for prostate cancer. While it is believed that adequate zinc consumption may prevent abnormal prostate growth, it is unclear whether supplementing with zinc will entirely shrink the prostate once growth has occurred.
Other Treatments for BPH
The Effects of Zinc Deficiency in Men
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While many pharmaceutical interventions are available to treat symptoms of BPH, one natural herbal supplement frequently taken by enlarged prostate sufferers is Saw Palmetto. According Medline Plus, numerous studies have shown that saw palmetto is effective in easing BPH symptoms. The Linus Pauling Institute also notes that phytosterols, plant compounds that are similar to cholesterol, are potentially helpful in treating BPH 3. In several clinical trials, phytosterols were found to improve symptoms of the lower urinary tract related to BPH. Foods containing phytosterols include unrefined vegetable oils, legumes, nuts and whole grains.
- While many pharmaceutical interventions are available to treat symptoms of BPH, one natural herbal supplement frequently taken by enlarged prostate sufferers is Saw Palmetto.
- The Linus Pauling Institute also notes that phytosterols, plant compounds that are similar to cholesterol, are potentially helpful in treating BPH 3.
Related Articles
References
- New York Times Health Guide: Enlarged Prostate
- National Institutes of Health: Office of Dietary Supplements: Zinc
- Linus Pauling Institute; Phytosterols; Jane Higdon, Ph.D.; Sept. 2008
- Medline Plus; Enlarged Prostate; aug. 10, 2009
- Linus Pauling Institute: Zinc and Prostate Cancer: Emily Ho, PhD and Michelle Yan; May 2005
- Lee CL, Kuo HC. Pathophysiology of benign prostate enlargement and lower urinary tract symptoms: Current concepts. Ci Ji Yi Xue Za Zhi. 2017;29(2):79–83. doi:10.4103/tcmj.tcmj_20_17
- Grozescu T, Popa F. Prostate cancer between prognosis and adequate/proper therapy. J Med Life. 2017;10(1):5–12. PMID: 28255369
- Benign enlarged prostate: Overview. InformedHealth.org [Internet]. Published January 25, 2018.
- Weiss JP. Nocturia: focus on etiology and consequences. Rev Urol. 2012;14(3-4):48–55. PMID: 23526404
- Serlin DC, Heidelbaugh JJ, Stoffel JT. Urinary Retention in Adults: Evaluation and Initial Management. Am Fam Physician. 2018;98(8):496-503. PMID: 30277739
- Rowe TA, Juthani-Mehta M. Urinary tract infection in older adults. Aging health. 2013;9(5):10.2217/ahe.13.38. doi:10.2217/ahe.13.38
- Rodgers M, Nixon J, Hempel S, et al. Diagnostic tests and algorithms used in the investigation of haematuria: systematic reviews and economic evaluation. Health Technol Assess. 2006;10(18):iii-iv, xi-259. doi:10.3310/hta10180
- Liu TT, Thomas S, Mclean DT, et al. Prostate enlargement and altered urinary function are part of the aging process. Aging (Albany NY). 2019;11(9):2653–2669. doi:10.18632/aging.101938
- Roehrborn CG. Benign prostatic hyperplasia: an overview. Rev Urol. 2005;7 Suppl 9(Suppl 9):S3–S14. PMID: 16985902
- Prostate Enlargement (Benign Prostatic Hyperplasia). National Institute of Diabetes and Digestive and Kidney Diseases. Published September 1, 2014.
- Pontari MA, Ruggieri MR. Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol. 2004;172(3):839–845. doi:10.1097/01.ju.0000136002.76898.04
- Litwin MS, Tan HJ. The Diagnosis and Treatment of Prostate Cancer: A Review. JAMA. 2017;317(24):2532-2542. doi:10.1001/jama.2017.7248
- Mandaliya H, Sung J, Hill J, Samali R, George M. Prostate Cancer: Cases of Rare Presentation and Rare Metastasis. Case Rep Oncol. 2015;8(3):526–529. Published 2015 Nov 26. doi:10.1159/000442045
- Palmerola R, Smith P, Elliot V, et al. The digital rectal examination (DRE) remains important - outcomes from a contemporary cohort of men undergoing an initial 12-18 core prostate needle biopsy. Can J Urol. 2012;19(6):6542-7. PMID: 23228289
- Chang RT, Kirby R, Challacombe BJ. Is there a link between BPH and prostate cancer?. Practitioner. 2012;256(1750):13-6, 2. PMID: 22792684
- De Angelis G, Rittenhouse HG, Mikolajczyk SD, Blair Shamel L, Semjonow A. Twenty Years of PSA: From Prostate Antigen to Tumor Marker. Rev Urol. 2007;9(3):113–123. PMID: 17934568
- Prostate cancer: Overview. InformedHealth.org [Internet]. Published February 22, 2018.
- Yu Y, Sikorski P, Bowman-Gholston C, Cacciabeve N, Nelson KE, Pieper R. Diagnosing inflammation and infection in the urinary system via proteomics. J Transl Med. 2015;13:111. Published 2015 Apr 8. doi:10.1186/s12967-015-0475-3
- James LJ, Wong G, Craig JC, et al. Men's perspectives of prostate cancer screening: A systematic review of qualitative studies. PLoS One. 2017;12(11):e0188258. Published 2017 Nov 28. doi:10.1371/journal.pone.0188258
- Feneley RC, Hopley IB, Wells PN. Urinary catheters: history, current status, adverse events and research agenda [published correction appears in J Med Eng Technol. 2016;40(2):59]. J Med Eng Technol. 2015;39(8):459–470. doi:10.3109/03091902.2015.1085600
- Colli E, Artibani W, Goka J, Parazzini F, Wein AJ. Are urodynamic tests useful tools for the initial conservative management of non-neurogenic urinary incontinence? A review of the literature. Eur Urol. 2003;43(1):63-9. doi:10.1016/s0302-2838(02)00494-3
- May M, Brookman-amissah S, Hoschke B, Gilfrich C, Braun KP, Kendel F. Post-void residual urine as a predictor of urinary tract infection--is there a cutoff value in asymptomatic men?. J Urol. 2009;181(6):2540-4. doi:10.1016/j.juro.2009.01.103
- Turkbey B, Pinto PA, Choyke PL. Imaging techniques for prostate cancer: implications for focal therapy. Nat Rev Urol. 2009;6(4):191–203. doi:10.1038/nrurol.2009.27
- Demaagd GA, Davenport TC. Management of urinary incontinence. P T. 2012;37(6):345–361H. PMID: 22876096
- Hall SA, Yang M, Gates MA, Steers WD, Tennstedt SL, McKinlay JB. Associations of commonly used medications with urinary incontinence in a community based sample. J Urol. 2012;188(1):183–189. doi:10.1016/j.juro.2012.02.2575
- Nickel JC. Comparison of trials with finasteride and dutasteride. Rev Urol. 2004;6 Suppl 9(Suppl 9):S31–S39. PMID: 16985923
- Chapple CR. A Comparison of Varying alpha-Blockers and Other Pharmacotherapy Options for Lower Urinary Tract Symptoms. Rev Urol. 2005;7 Suppl 4(Suppl 4):S22–S30. PMID: 16986051
- Lipsky BA, Byren I, Hoey CT. Treatment of bacterial prostatitis. Clin Infect Dis. 2010;50(12):1641-52. doi:10.1086/652861
- Welliver C, Helo S, McVary KT. Technique considerations and complication management in transurethral resection of the prostate and photoselective vaporization of the prostate. Transl Androl Urol. 2017;6(4):695–703. doi:10.21037/tau.2017.07.30
- Li M, Qiu J, Hou Q, et al. Endoscopic enucleation versus open prostatectomy for treating large benign prostatic hyperplasia: a meta-analysis of randomized controlled trials. PLoS One. 2015;10(3):e0121265. Published 2015 Mar 31. doi:10.1371/journal.pone.0121265
- Lorenzo G, Hughes TJR, Dominguez-Frojan P, Reali A, Gomez H. Computer simulations suggest that prostate enlargement due to benign prostatic hyperplasia mechanically impedes prostate cancer growth. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1152-1161. Published Jan 2019. doi:10.1073/pnas.1815735116
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Michelle Matte is an accomplished fitness professional who holds certifications in personal training, pilates, yoga, group exercise and senior fitness. She has developed curricula for personal trainers and group exercise instructors for an international education provider. In her spare time, Matte writes fiction and blogs.