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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- Journal of the American Medical Association: Probiotics for the Prevention and Treatment of Antibiotic-associated Diarrhea: A Systematic Review and Meta-analysis
- Journal of the American Medical Association: Probiotics for the Prevention and Treatment of Antibiotic-associated Diarrhea: A Systematic Review and Meta-analysis
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What Is the Daily Dose of Acidophilus?
Acidophilus, known scientifically as Lactobacillus acidophilus, is a species of "good" or "friendly" bacteria found primarily in the small intestine 1. This potentially beneficial species of bacteria and others like it are classified as probiotics because they may help your body keep the ratio of good bacteria in balance. As a supplement, acidophilus is the most commonly used probiotic, according to the University of Maryland Medical Center, but the amount you should take daily can vary 1.
Taking Acidophilus
The recommended dose of acidophilus depends on the intended use. Work with your doctor if you're taking acidophilus to treat a digestive problem. The most common reasons for taking acidophilus are to maintain intestinal health and to treat or prevent various forms of diarrhea. Some acidophilus preparations require refrigeration to maintain the best quality. You can choose a preparation that does not require refrigeration if you're taking it for traveler's diarrhea and won't have access to a fridge while traveling.
- The recommended dose of acidophilus depends on the intended use.
- Work with your doctor if you're taking acidophilus to treat a digestive problem.
Treating and Preventing Diarrhea
Acidophilus for Gas & Bloating
Learn More
Researchers completed a systematic review of published evidence and found that taking probiotics is effective at treating and preventing antibiotic-associated diarrhea 3. The results were published in the May 2012 issue of the "Journal of the American Medical Association." The typical dose of acidophilus for treating and preventing diarrhea is 1 to 2 billion colony-forming units, or CFUs per day, according to the UMMC 2.
Maintaining Digestive Health
There are several mechanisms by which probiotics help keep your gut healthy, according to a review published in the January 2009 issue of the journal "Current Drug Metabolism." Probiotics help to inhibit the growth of bad bacteria, neutralize toxins, normalize gut mucosa and secrete antimicrobial substances, among other things. The typical dose of acidophilus for maintaining intestinal health is 1 to 15 billion CFUs per day, according to the UMMC.
Acidophilus Supplement Safety
Do You Have to Take Probiotics on an Empty Stomach?
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Taking acidophilus may cause gastrointestinal side effects such as gas, upset stomach and diarrhea. If you're currently prescribed antibiotics, the UMMC recommends taking acidophilus two hours before or after to avoid interaction. Ask your doctor before taking acidophilus if you take any medications or have any health problems.
Related Articles
References
- University of Maryland Medical Center: Lactobacillus Acidophilus
- American Cancer Society: Acidophilus
- Journal of the American Medical Association: Probiotics for the Prevention and Treatment of Antibiotic-associated Diarrhea: A Systematic Review and Meta-analysis
- Current Drug Metabolism: The Impact of Probiotic on Gut Health
- Guo H, Zheng Y, Wang B, Li Z. A Note on an Improved Self-Healing Group Key Distribution Scheme. Sensors (Basel). 2015;15(10):25033-8. doi:10.3390/fermentation5020041
- Goldenberg JZ, Yap C, Lytvyn L, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2017;12:CD006095. doi:10.1002/14651858.CD006095.pub4.
- Schettle L, Lio PA. Probiotics: The Search for Bacterial Balance. National Eczema Association.
- Understanding the health benefits of taking probiotics. Harvard Medical School. March 2014.
- Sun J, Buys N. Effects of probiotics consumption on lowering lipids and CVD risk factors: a systematic review and meta-analysis of randomized controlled trials. Ann Med. 2015;47(6):430-40. doi:10.3109/07853890.2015.1071872
- Cho YA, Kim J. Effect of Probiotics on Blood Lipid Concentrations: A Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore). 2015;94(43):e1714. doi:10.1097/MD.0000000000001714.
- Homayouni A, Bastani P, Ziyadi S, et al. Effects of probiotics on the recurrence of bacterial vaginosis: a review. J Low Genit Tract Dis. 2014;18(1):79-86. doi:10.1097/LGT.0b013e31829156ec
- Matsubara VH, Wang Y, Bandara HM, Mayer MP, Samaranayake LP. Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation. Appl Microbiol Biotechnol. 2016;100(14):6415-26. doi:10.1007/s00253-016-7527-3
- Kovachev SM, Vatcheva-Dobrevska RS. Local Probiotic Therapy for Vaginal Candida albicans Infections. Probiotics Antimicrob Proteins. 2015;7(1):38-44. doi:10.1007/s12602-014-9176-0.
- Huang R, Wang K, Hu J. Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016;8(8). doi:10.3390/nu8080483
- Microorganisms & Microbial-Derived Ingredients Used in Food (Partial List). US Food & Drug Administration. January 2018.
- Karlsson S, Brantsæter AL, Meltzer HM, Jacobsson B, Barman M, Sengpiel V. Maternal probiotic milk intake during pregnancy and breastfeeding complications in the Norwegian Mother and Child Cohort Study. Eur J Nutr. 2019. doi:10.1007/s00394-019-02072-8
- Taking Medications: What You Need to Know to Stay Safe. Cleveland Clinic. March 2014.
- Kadooka Y, Sato M, Ogawa A, et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial. Br J Nutr. 2013;110(9):1696-703. doi:10.1017/S0007114513001037
- Zhang Q, Wu Y, Fei X. Effect of probiotics on glucose metabolism in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. Medicina (Kaunas). 2016;52(1):28-34. doi:10.1016/j.medici.2015.11.008
- Cho YA, Kim J. Effect of Probiotics on Blood Lipid Concentrations: A Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore). 2015;94(43):e1714. doi:10.1097/MD.0000000000001714.
- Goldenberg JZ, Yap C, Lytvyn L, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2017;12:CD006095. doi:10.1002/14651858.CD006095.pub4.
- Huang R, Wang K, Hu J. Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016.8(8). pii: E483. doi:10.3390/nu8080483.
- Kadooka Y, Sato M, Ogawa A, et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial. Br J Nutr. 2013;110(9):1696-703. doi:10.1017/S0007114513001037.
- Kovachev SM, Vatcheva-Dobrevska RS. Local Probiotic Therapy for Vaginal Candida albicans Infections. Probiotics Antimicrob Proteins. 2015;7(1):38-44. doi:10.1007/s12602-014-9176-0.
- Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009;124(2):e172-9. doi:10.1542/peds.2008-2666.
- Matsubara VH, Wang Y, Bandara HM, Mayer MP, Samaranayake LP. Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation. Appl Microbiol Biotechnol. 2016;100(14):6415-26. doi:10.1007/s00253-016-7527-3.
- Mayo Clinic. Acidophilus. mayoclinic.org/drugs-supplements-acidophilus/art-20361967
- NIH: National Center for Complementary and Alternative Medicine. Probiotics: What You Need To Know. nccih.nih.gov/health/probiotics/introduction.htm
- Sun J, Buys N. Effects of probiotics consumption on lowering lipids and CVD risk factors: a systematic review and meta-analysis of randomized controlled trials. Ann Med. 2015;47(6):430-40. doi:10.3109/07853890.2015.1071872
- Zhang Q, Wu Y, Fei X. Effect of probiotics on glucose metabolism in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. Medicina (Kaunas). 2016;52(1):28-34. doi:10.1016/j.medici.2015.11.008.
Writer Bio
Janet Renee is a clinical dietitian with a special interest in weight management, sports dietetics, medical nutrition therapy and diet trends. She earned her Master of Science in nutrition from the University of Chicago and has contributed to health and wellness magazines, including Prevention, Self, Shape and Cooking Light.