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Hives from using caffeine are a sign of an allergic reaction. Caffeine is a drug that is commonly found in coffee, sodas, tea, energy drinks and used in combination with other medications, such as pain relievers. Drugs.com states that hives are a symptom of a severe allergic reaction called anaphylaxis 2. Anaphylaxis is a rare reaction that can cause life-threatening symptoms within minutes of ingesting a substance that you’re body is hypersensitive toward 2.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Caffeine can cause common allergy symptoms that are not related to an allergic reaction but are rather common side effects of the drug. For example, caffeine can cause heart palpitations, nausea, headaches and vomiting if you ingest too much or cannot tolerate the substance. A caffeine allergy occurs when your body creates immunoglobulin E antibodies to fight off the substance, according to the American Academy of Allergy, Asthma and Immunology. IgE antibodies are disease fighting agents that the body creates when it mistakes caffeine for a harmful substance. The production of IgE antibodies cause mast cells to produce histamine, a chemical that leads to inflammation in soft tissue.
- Caffeine can cause common allergy symptoms that are not related to an allergic reaction but are rather common side effects of the drug.
- IgE antibodies are disease fighting agents that the body creates when it mistakes caffeine for a harmful substance.
Can Excess Caffeine Cause Rashes?
Hives are a common skin rash that is related to allergic reactions. Hives are a rash that develops in clusters of welts that are very itchy. Hives from an allergy to caffeine are the result of increased levels of histamine in the skin. Histamine in the surface of the skin leads to inflammation, swelling and irritation. Most cases of hives do not cause any health concern, unless they form in the throat or inner ear. Hives are a sign of anaphylaxis that your doctor needs to evaluate 2. Hives can form on one part of the body and move without a cause and typically subside within a few hours.
- Hives are a common skin rash that is related to allergic reactions.
- Hives are a rash that develops in clusters of welts that are very itchy.
Anaphylaxis is commonly the result of food allergies, insect bites and drug allergies 2. Hives are a common sign of a severe allergic reaction that affects the entire body. After you ingest caffeine, your immune system may release excessive amounts of IgE antibodies and histamine, causing tissues in various parts of the body to become inflamed. This can cause your body to experience a state of shock where you cannot breathe, may lose consciousness and experience a sudden drop in blood pressure. If not treated, anaphylaxis may lead to death 2.
Allergic Reactions to Caffeine
If you’re diagnosed with a caffeine allergy, avoid all consumption of caffeine to avoid an allergic reaction. Hives that develop if you accidentally ingest caffeine may be treated by taking an antihistamine to reduce histamine in the body and by applying hydrocortisone cream.
Can Excess Caffeine Cause Rashes?
Allergic Reactions to Caffeine
Caffeine and Swollen Lips
Caffeine Sensitivity & Itching Skin
Caffeine & Back Pain
Does Cocoa Butter Contain Caffeine?
Does Caffeine Cause Stomach Pain?
Congestive Heart Failure & Caffeine
Caffeine Pills and a Stomach Ache
Coffee Allergy & Rash
- Drugs.com: Caffeine Side Effect
- MedlinePlus: Anaphylaxis
- Tupper J, Visser S. Anaphylaxis: A review and update. Can Fam Physician. 2010;56(10):1009-11.
- Dewachter P, Mouton-faivre C, Emala CW. Anaphylaxis and anesthesia: controversies and new insights. Anesthesiology. 2009;111(5):1141-50. doi:10.1097/ALN.0b013e3181bbd443
- Cianferoni A, Muraro A. Food-induced anaphylaxis. Immunol Allergy Clin North Am. 2012;32(1):165-95. doi:10.1016/j.iac.2011.10.002
- Ben-shoshan M, Clarke AE. Anaphylaxis: past, present and future. Allergy. 2011;66(1):1-14. doi:10.1111/j.1398-9995.2010.02422.x
- Kim SY, Kim MH, Cho YJ. Different clinical features of anaphylaxis according to cause and risk factors for severe reactions. Allergol Int. 2018;67(1):96-102. doi:10.1016/j.alit.2017.05.005
- Accetta D, Kelly KJ. Recognition and management of the latex-allergic patient in the ambulatory plastic surgical suite. Aesthet Surg J. 2011;31(5):560-5. doi:10.1177/1090820X11411580
- Barg W, Medrala W, Wolanczyk-medrala A. Exercise-induced anaphylaxis: an update on diagnosis and treatment. Curr Allergy Asthma Rep. 2011;11(1):45-51. doi:10.1007/s11882-010-0150-y
- Sánchez-borges M, Suárez-chacon R, Capriles-hulett A, Caballero-fonseca F, Iraola V, Fernández-caldas E. Pancake syndrome (oral mite anaphylaxis). World Allergy Organ J. 2009;2(5):91-6. doi:10.1186/1939-4551-2-5-91
- Kuehn BM. Tick Bite Linked to Red Meat Allergy. JAMA. 2018;319(4):332. doi:10.1001/jama.2017.20802
- Reber LL, Hernandez JD, Galli SJ. The pathophysiology of anaphylaxis. J Allergy Clin Immunol. 2017;140(2):335-348. doi:10.1016/j.jaci.2017.06.003
- Mulla ZD, Simons FE. Concomitant chronic pulmonary diseases and their association with hospital outcomes in patients with anaphylaxis and other allergic conditions: a cohort study. BMJ Open. 2013;3(7) doi:10.1136/bmjopen-2013-003197
- Lieberman P, Simons FE. Anaphylaxis and cardiovascular disease: therapeutic dilemmas. Clin Exp Allergy. 2015;45(8):1288-95. doi:10.1111/cea.12520
- Idiopathic Allergy Factsheet November 2017. The Anaphylaxis Campaign. https://www.anaphylaxis.org.uk/wp-content/uploads/2015/06/Idiopathic-Anaphylaxis-Factsheet-Nov-2017.pdf.
- Anaphylaxis. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/anaphylaxis/symptoms-causes/syc-20351468.
- Drug Allergies: Anaphylactic Reactions (Anaphylaxis). Institute for Quality and Efficiency in Health Care. https://www.ncbi.nlm.nih.gov/books/NBK464181/.
- Nwaru BI, Dhami S, Sheikh A. Idiopathic Anaphylaxis. Current Treatment Options in Allergy. 2017;4(3):312-319. doi:10.1007/s40521-017-0136-2.
- Sanchez-Borges M, Suarez Chacon R, Capriles-Hulett A, Caballo-Fonseca F, Fernandez-Caldas E. Anaphylaxis From Ingestion of Mites: Pancake Anaphylaxis. J Allergy Clin Immunol. 2013;131:31-5.
Diane Marks started her writing career in 2010 and has been in health care administration for more than 30 years. She holds a registered nurse license from Citizens General Hospital School of Nursing, a Bachelor of Arts in health care education from California University of Pennsylvania and a Master of Science in health administration from the University of Pittsburgh.