Choline & Headaches

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Choline is considered an essential nutrient for humans and often grouped with the B vitamins because of its physiological effects. Choline also is to synthesize the neurotransmitter acetylcholine, a brain messenger involved in higher brain functions and muscle control. Some studies, particularly from the 1980s, indicated that low levels of choline in the bloodstream are linked to certain types of migraine headaches.


Choline is not a vitamin, but it is an essential nutrient that must be obtained from dietary sources. In addition to being needed for acetylcholine synthesis in the brain, choline is an essential component of cell membranes and helps the liver and gallbladder function normally, as cited in “Biochemical, Physiological and Molecular Aspects of Human Nutrition.” Choline also is important to the health of the myelin sheaths that cover nerve fibers and allow for efficient transmission of electrical brain signals. As such, choline is associated with higher brain functions, such as memory, mood and cognition.

Choline and Cluster Headaches

There is some research that links low levels of choline to cluster headaches, severe migraine-like headaches that occur in predictable clusters over many days. An study published in a 1984 edition of the “British Medical Journal” found that the red blood cell choline levels in those suffering from cluster headaches was significantly less than an age-related control group. Further, when lithium was given for pain relief, the patient’s choline concentrations rose 78 times above the control level, indicating a cause-and-effect relationship. Some health professionals have made the correlation between high choline levels and reduced incidence of all migraine headaches, but not all varieties of migraine have the same triggers or involve the same biochemistry, as cited in “The Mechanism and Management of Headache.”

Choline Recommendations

There is no FDA dietary recommendations for choline, but it does have a suggested adequate intake, which is 425 mg per day for women and 550 mg for men. Choline is found in many foods, particularly beef liver, eggs, fish, chicken, milk, cauliflower, spinach and wheat germ. Choline cannot be taken directly as a dietary supplement, which is why lecithin is recommended as a substitute. For those suffering from headaches, migraines and cluster varieties in particular, supplementing with lecithin might be a beneficial experiment, as it is completely safe with no known side effects.

Deficiency Issues

Choline is found in many foods, but those who shy away from meats and eggs are at risk of deficiency. In addition to cluster headaches, choline deficiency has been linked to liver disease, reduced kidney function, neurological disorders, memory deficiencies, infertility, high blood pressure, muscle twitching, bone abnormalities and the promotion of cancer, as cited in “Human Biochemistry and Disease.”