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Seizures interfere with a person's life on many levels. The interruption in nerve cell messaging that controls body movements and function can result in changes in behavior, cause muscle spasms or full body convulsions. The amount of folic acid your body requires may also be a victim of this disorder.
Folic Acid Defined
Folic acid is a B vitamin also known as folate. Folate is the natural form you can find in certain foods, while folic acid is the manmade version you take in over-the-counter multivitamins or supplements. It aids in the production of blood cells, and can reduce birth defects by 50 to 70 percent, according to the Centers for Disease Control and Prevention 1. Although it can lower the risk of heart disease and some cancers for men, it appears the focus of its benefits are teenage girls and women who may become pregnant. The recommended daily dose is 0.4 mg.
- Folic acid is a B vitamin also known as folate.
- Folate is the natural form you can find in certain foods, while folic acid is the manmade version you take in over-the-counter multivitamins or supplements.
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Certain seizure medications interfere with the absorption of folic acid in your body, which can result in a deficiency of this vitamin. These medications include phenytoin, carbamazepine and phenobarbital. When taking these drugs, your doctor may recommend increasing your dose of folic acid to 4 mg per day. If you take more than two seizure drugs, or a minimum of 1,000 mg of valproate, you may require an even higher dose.
- Certain seizure medications interfere with the absorption of folic acid in your body, which can result in a deficiency of this vitamin.
Seizures and Pregnancy
Folic acid can play a more important role for women who have seizures and become pregnant. The hormone changes from pregnancy can change the way your body processes your seizure medication, which can pose a greater danger to the fetus. All women face the risk of delivering a baby with a birth defect. However, in women without seizures the risk is 2 to 3 percent, while in women with seizures the risk is 6 to 8 percent. Increasing the amount of folic acid you take each day can help prevent this. Your doctor will determine the dosage based on your personal medical history.
- Folic acid can play a more important role for women who have seizures and become pregnant.
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You can receive some benefits of folic acid, or folate, in the foods you eat, however, it may not be enough for you to receive the full amount your body needs. WomensHealth.gov recommends taking a vitamin containing folic acid each day, even if you consume a well-balanced diet. Some natural sources of this vitamin include dark, leafy greens such as:
- turnip greens
- romaine lettuce
Fruits and fruit juices such as oranges, strawberries and orange juice. Dried peas and beans such as pinto, navy, lima, black-eyed and chickpeas. Whole grain cereals and liver meat such as liver are good sources as well.
- You can receive some benefits of folic acid, or folate, in the foods you eat, however, it may not be enough for you to receive the full amount your body needs.
- Some natural sources of this vitamin include dark, leafy greens such as: * spinach
* turnip greens
* romaine lettuce
* asparagus Fruits and fruit juices such as oranges, strawberries and orange juice.
When choosing a vitamin or folic acid supplement, read the label. Make sure it says, "400 mcg," or "100 percent" next to the daily value. If you have seizures, and are planning on having a baby, speak to your doctor first. He may want to change the dose of your medication, or try a safer medication for the sake of your baby.
- When choosing a vitamin or folic acid supplement, read the label.
- He may want to change the dose of your medication, or try a safer medication for the sake of your baby.
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- Centers for Disease Control and Prevention: Facts About Folic Acid
- Donnelly JG. Folic acid. Crit Rev Clin Lab Sci. 2001;38(3):183-223.
- Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014;44(5):480-8.
- Figueiredo JC, Grau MV, Haile RW, et al. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst. 2009;101(6):432–435. doi:10.1093/jnci/djp019
- Spina bifida and anencephaly before and after folic acid mandate--United States, 1995-1996 and 1999-2000. MMWR Morb Mortal Wkly Rep. 2004;53(17):362-5.
- Bastian H. Lucy Wills (1888-1964): the life and research of an adventurous independent woman. J R Coll Physicians Edinb. 2008;38(1):89-91.
- Visentin M, Zhao R, Goldman ID. The antifolates. Hematol Oncol Clin North Am. 2012;26(3):629–ix. doi:10.1016/j.hoc.2012.02.002
- Greenberg JA, Bell SJ, Guan Y, Yu YH. Folic Acid supplementation and pregnancy: more than just neural tube defect prevention. Rev Obstet Gynecol. 2011;4(2):52–59.
- Northrup H, Volcik KA. Spina bifida and other neural tube defects. Curr Probl Pediatr. 2000;30(10):313-32.
- Crider KS, Bailey LB, Berry RJ. Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients. 2011;3(3):370–384. doi:10.3390/nu3030370
- Fousekis FS, Theopistos VI, Katsanos KH, Tsianos EV, Christodoulou DK. Hepatobiliary Manifestations and Complications in Inflammatory Bowel Disease: A Review. Gastroenterology Res. 2018;11(2):83–94. doi:10.14740/gr990w
- Hariz A, Bhattacharya PT. Megaloblastic Anemia. [Updated 2019 Jan 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537254/
- Maron BA, Loscalzo J. The treatment of hyperhomocysteinemia. Annu Rev Med. 2009;60:39–54. doi:10.1146/annurev.med.60.041807.123308
- Tinelli C, Di Pino A, Ficulle E, Marcelli S, Feligioni M. Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies. Front Nutr. 2019;6:49. Published 2019 Apr 24. doi:10.3389/fnut.2019.00049
- Juhlin L, Olsson MJ. Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure. Acta Derm Venereol. 1997;77(6):460-2.
- Merle BM, Silver RE, Rosner B, Seddon JM. Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study. Am J Clin Nutr. 2016;103(4):1135-44.
- Tian T, Yang KQ, Cui JG, Zhou LL, Zhou XL. Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease. Am J Med Sci. 2017;354(4):379-387.
- Hsu CY, Chiu SW, Hong KS, et al. Folic Acid in Stroke Prevention in Countries without Mandatory Folic Acid Food Fortification: A Meta-Analysis of Randomized Controlled Trials. J Stroke. 2018;20(1):99–109. doi:10.5853/jos.2017.01522
- McRae MP. High-dose folic acid supplementation effects on endothelial function and blood pressure in hypertensive patients: a meta-analysis of randomized controlled clinical trials. J Chiropr Med. 2009;8(1):15–24. doi:10.1016/j.jcm.2008.09.001
- Zhao G, Ford ES, Li C, Greenlund KJ, Croft JB, Balluz LS. Use of folic acid and vitamin supplementation among adults with depression and anxiety: a cross-sectional, population-based survey. Nutr J. 2011;10:102.
- Gisondi P, Fantuzzi F, Malerba M, Girolomoni G. Folic acid in general medicine and dermatology. J Dermatolog Treat. 2007;18(3):138-46.
- Reynolds EH. Folic acid, ageing, depression, and dementia. BMJ. 2002;324(7352):1512–1515. doi:10.1136/bmj.324.7352.1512
- Nucera E, Aruanno A, Mezzacappa S, Pascolini L, Buonomo A, Schiavino D. Hypersensitivity reactions to folic acid: Three case reports and a review of the literature. Int J Immunopathol Pharmacol. 2018;32:2058738418817704. Published 2018 Dec 17. doi:10.1177/2058738418817704
- Pieroth R, Paver S, Day S, Lammersfeld C. Folate and Its Impact on Cancer Risk. Curr Nutr Rep. 2018;7(3):70–84. doi:10.1007/s13668-018-0237-y
- Lewis DP, Van dyke DC, Willhite LA, Stumbo PJ, Berg MJ. Phenytoin-folic acid interaction. Ann Pharmacother. 1995;29(7-8):726-35.
- Selhub J, Dhar GJ, Rosenberg IH. Inhibition of folate enzymes by sulfasalazine. J Clin Invest. 1978;61(1):221-4.
- Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016;8(2):68. Published 2016 Jan 27. doi:10.3390/nu8020068
- Starr RR. Too little, too late: ineffective regulation of dietary supplements in the United States. Am J Public Health. 2015;105(3):478–485. doi:10.2105/AJPH.2014.302348
- Troesch B, Demmelmair J, Gimpfl M, et al. Suitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: A randomized-controlled trial. PLoS One. 2019;14(8):e0216790. Published 2019 Aug 19. doi:10.1371/journal.pone.0216790
- Pintó X, Vilaseca MA, Balcells S, et al. A folate-rich diet is as effective as folic acid from supplements in decreasing plasma homocysteine concentrations. Int J Med Sci. 2005;2(2):58–63. doi:10.7150/ijms.2.58
- American Academy of Pediatrics: Committee on Genetics. Folic acid for the prevention of neural tube defects. Pediatrics. 1999 Aug;104(2 Pt 1):325-7.
- Juhlin, L. and Olsson, M. Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure. Acta Derm Venereol. 1997 Nov;77(6):460-2. DOI: 10.2340/000155555577460462.
- Li, Y.; Huang, T.; Zheng, Y. et al. Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta‐Analysis of Randomized Controlled Trials. JAHA. 2016;5(8):pii: e003768. DOI: 10.1161/JAHA.116.003768.
- Merle, B.; Silver, R.; Rosner, B. et al. Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study. Am J Clin Nutr. 2016 Apr;103(4):1135-44. DOI: 10.3945/ajcn.115.117606.
- Zhao, G.; Ford, E.; Li, C. et al. Use of folic acid and vitamin supplementation among adults with depression and anxiety: a cross-sectional, population-based survey. Nutrition Journal. 2011;10:102. DOI: 10.1186/1475-2891-10-102.
Based in Jamestown, Pa., Hannah Rice Myers has more than 10 years of experience as a freelance writer, specializing in the health industry. Many of her articles have appeared in newspapers, as well as "Curing Epilepsy: Hope Through Research." Rice Myers received her master's degree in nursing from Upstate Medical University in 2001.