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Choline Overdose
Choline makes up an essential part of your diet. The nutrient contributes to the production of acetylcholine, a chemical involved in brain signaling, and it also plays a role in the breakdown of fats in your body and makes up an important component of your cell membranes. You require some choline each day, but consuming large doses of the nutrient is harmful.
Tolerable Upper Limit
The tolerable upper limit for choline represents the amount of the nutrient most people can consume without adverse effects. Exceeding the tolerable upper intake limit may cause side effects and lead to a choline overdose. The Linus Pauling Institute indicates that adults should not consume more than 3.5 g of choline daily 1. The tolerable upper limits for adolescents and children are slightly lower: 3 and 2 g, respectively. You can help prevent an accidental choline overdose in your children by keeping any supplements out of reach and only giving your children choline supplements if instructed by a doctor.
- The tolerable upper limit for choline represents the amount of the nutrient most people can consume without adverse effects.
Symptoms of Choline Overdose
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Consuming too much choline can lead to a number of side effects. You may experience dizziness or lightheadedness in some cases, since very high doses of choline can lower your blood pressure. In addition, choline overdose can cause excessive sweating and salivation as well as a fishy body odor caused by byproducts of choline metabolism in your body. Choline magnesium trisalicylate, one type of choline-containing supplement, can also lead to diminished liver functioning, though this effect may occur due to compounds in the supplement other than choline.
- Consuming too much choline can lead to a number of side effects.
- Choline magnesium trisalicylate, one type of choline-containing supplement, can also lead to diminished liver functioning, though this effect may occur due to compounds in the supplement other than choline.
Recommendations
Consuming your recommended intake of choline each day helps provide your body with the nutrients it requires. The U.S. Department of Agriculture says that men at or above the age of 19 require 500 mg of choline each day, while women require 425 mg of the nutrient. Your total choline intake can come from dietary sources or from nutritional supplements recommended by your doctor.
Dietary Sources
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A number of foods provide choline, allowing you to consume your adequate intake of the nutrient without the risk of overdose from supplements. The U.S. Department of Agriculture lists eggs -- particularly egg yolks -- chicken liver, turkey liver and enriched breakfast cereals as particularly rich sources of choline. In addition, several fruits and vegetables, including figs, avocado, brussels sprouts and corn all contain choline. Following a balanced diet containing a range of healthy foods will likely provide adequate choline without the need for supplements.
- A number of foods provide choline, allowing you to consume your adequate intake of the nutrient without the risk of overdose from supplements.
- The U.S. Department of Agriculture lists eggs -- particularly egg yolks -- chicken liver, turkey liver and enriched breakfast cereals as particularly rich sources of choline.
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References
- Linus Pauling Institute; Choline; Jane Higdon; November 2003
- Gibb AJ. Choline and acetylcholine: what a difference an acetate makes! J Physiol (Lond). 2017;595(4):1021-1022. doi:10.1113/JP273666
- Zeisel SH, Da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67(11):615-23. doi:10.1111/j.1753-4887.2009.00246.x
- Nurk E, Refsum H, Bjelland I, et al. Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. Br J Nutr. 2013;109(3):511-9. doi:10.1017/S0007114512001249
- Bertoia ML, Pai JK, Cooke JP, et al. Plasma homocysteine, dietary B vitamins, betaine, and choline and risk of peripheral artery disease. Atherosclerosis. 2014;235(1):94-101. doi:10.1016/j.atherosclerosis.2014.04.010
- Fischer LM, Dacosta KA, Kwock L, et al. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr. 2007;85(5):1275-85. doi:10.1093/ajcn/85.5.1275
- Caudill MA. Pre- and postnatal health: evidence of increased choline needs. J Am Diet Assoc. 2010;110(8):1198-206. doi:10.1016/j.jada.2010.05.009
- Da costa KA, Gaffney CE, Fischer LM, Zeisel SH. Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr. 2005;81(2):440-4. doi:10.1093/ajcn.81.2.440
- Sherriff JL, O'Sullivan TA, Properzi C, Oddo JL, Adams LA. Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes. Adv Nutr. 2016;7(1):5-13. doi:10.3945/an.114.007955
- NIH Office of Dietary Supplements. Choline. Updated July 9, 2019.
- Zheng Y, Li Y, Rimm EB, et al. Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men. Am J Clin Nutr. 2016;104(1):173-80. doi:10.3945/ajcn.116.131771
- Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): National Academies Press (US); 1998.
- Bertoia ML, Pai JK, Cooke JP, et al. Plasma homocysteine, dietary B vitamins, betaine, and choline and risk of peripheral artery disease. Atherosclerosis. 2014 Jul;235(1):94-101.
- Caudill MA. Pre- and postnatal health: evidence of increased choline needs. J Am Diet Assoc. 2010 Aug;110(8):1198-206.
- Fischer LM, daCosta KA, Kwock L, et al. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr. 2007 May;85(5):1275-85.
- Nurk E, Refsum H, Bjelland I, et al. Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. Br J Nutr. 2013 Feb 14;109(3):511-9.
- Zheng Y, Li Y, Rimm EB, et al. Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men. Am J Clin Nutr. 2016 Jul;104(1):173-80.
Writer Bio
Sylvie Tremblay holds a Master of Science in molecular and cellular biology and has years of experience as a cancer researcher and neuroscientist.