DHEA Supplements & Male Fertility
Dehydroepiandrosterone, usually called simply DHEA, is a hormone produced by the adrenal glands that helps manufacture male and female hormones. Testosterone and estrogen production both depend on DHEA. Levels of DHEA drop as people age; a man of 70 produces only 20 percent as much DHEA as he did as a young adult. Because DHEA decreases with age, proponents of DHEA supplements call it the anti-aging hormone and suggest that supplementation will restore youthful effects, including increased fertility. However, taking DHEA can decrease rather than increase sperm production. Do not take this supplement without your doctor’s approval.
Purpose
Men may take anabolic steroids to improve muscle mass by increasing testosterone production. DHEA has effects similar to that of anabolic steroids 1. DHEA can increase testosterone levels but can also suppress the body’s natural production of sex hormones.
Effects
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DHEA behaves similarly to androgen supplements, which can have negative effects of sperm production by inducing hypogonadotropic hypogonadism. Reversal of the condition can take three to six months, and some men may not recover pituitary function, urologist Mark Sigman, M.D., of Brown University reported in the May 2007 issue of “SRM,” a clinical publication of the American Society for Reproductive Medicine. DHEA can suppress male hormone production. A decrease in circulating levels of hormones that regulate sperm production will result in fewer sperm being produced. Sperm quality may also decrease. Testicular shrinkage may occur; if the size and firmness of the testicles are poor, it may take longer to improve the sperm count, urologist Russell Williams,M.D. of the Male Reproductive Clinic explains.
- DHEA behaves similarly to androgen supplements, which can have negative effects of sperm production by inducing hypogonadotropic hypogonadism.
- Testicular shrinkage may occur; if the size and firmness of the testicles are poor, it may take longer to improve the sperm count, urologist Russell Williams,M.D.
- of the Male Reproductive Clinic explains.
REsults
It takes around three months to produce and mature sperm. Stopping DHEA won’t give immediate results or a better sperm count overnight. A normal sperm count exceeds 20 million sperm per milliliter of semen; when levels drops below this point, called oligospermia, fertility problems can ensue. Other factors that play a part in a normal sperm count include the appearance of the sperm and their motility, or ability to move forward in a straight line.
- It takes around three months to produce and mature sperm.
- A normal sperm count exceeds 20 million sperm per milliliter of semen; when levels drops below this point, called oligospermia, fertility problems can ensue.
Considerations
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Sufficient studies on humans have not been conducted to assess the effects of DHEA on sperm count, Dr. Sigman states. Men who wish to preserve their fertility should not take DHEA supplements without discussing its use with their medical practitioner.
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References
- National Institutes of Health: NIDA InfoFacts: Steroids (Anabolic-Androgenic)
- California IVF: Male Infertility
- National Instutites of Health MedlinePlus. Wild yam. Updated April 18, 2018.
- National Institutes of Health MedlinePlus. DHEA. Updated May 29, 2019.
- Park SG, Hwang S, Kim JS, Park KC, Kwon Y, Kim KC. The association between dehydroepiandrosterone sulfate (DHEA-S) and bone mineral density in Korean men and women. J Bone Metab. 2017;24(1):31–36. doi:10.11005/jbm.2017.24.1.31
- von Mühlen D, Laughlin GA, Kritz-Silverstein D, Bergstrom J, Bettencourt R. Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial. Osteoporos Int. 2008;19(5):699–707. doi:10.1007/s00198-007-0520-z
- Peixoto C, Devicari Cheda JN, Nardi AE, Veras AB, Cardoso A. The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: A systematic review. Curr Drug Targets. 2014;15(9):901-14.
- Cleveland Clinic. Prasterone, DHEA tables or capsules (Dietary supplements).
- Archer DF. Dehydroepiandrosterone intra vaginal administration for the management of postmenopausal vulvovaginal atrophy. J Steroid Biochem Mol Biol. 2015 Jan;145:139-43. doi:10.1016/j.jsbmb.2014.09.003
- Freitas RP, Lemos TM, Spyrides MH, Sousa MB. Influence of cortisol and DHEA-S on pain and other symptoms in post menopausal women with fibromyalgia. J Back Musculoskelet Rehabil. 2012;25(4):245-52. doi:10.3233/BMR-2012-0331.
- Gómez-Santos C, Hernández-Morante JJ, Tébar FJ, et al. Differential effect of oral dehydroepiandrosterone-sulfate on metabolic syndrome features in pre- and postmenopausal obese women. Clin Endocrinol (Oxf). 2012;77(4):548-54. doi:10.1111/j.1365-2265.2011.04306.x.
- Panjari M, Davis SR. DHEA for postmenopausal women: a review of the evidence. Maturitas. 2010;66(2):172-9. doi:10.1016/j.maturitas.2009.12.017
Writer Bio
A registered nurse with more than 25 years of experience in oncology, labor/delivery, neonatal intensive care, infertility and ophthalmology, Sharon Perkins has also coauthored and edited numerous health books for the Wiley "Dummies" series. Perkins also has extensive experience working in home health with medically fragile pediatric patients.