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Glutathione Depletion Symptoms

By Rae Uddin

Glutathione is a substance your body uses to help prevent cell damage while your body is producing energy. If your stores of glutathione are depleted, you may have a medical condition referred to as glutathione synthetase deficiency. The disorder is rare and affects approximately 70 people throughout the world, according to the National Library of Medicine. If you have questions or concerns regarding glutathione depletion symptoms, consult your medical provider.

Hemolytic Anemia

Low levels of glutathione may affect your child's ability to produce red blood cells. Consequently, your child may develop hemolytic anemia as a symptom of this condition. Hemolytic anemia may cause fatigue, fever, pale or yellow skin, chills, dark urine, breathing difficulties, heart rate irregularities or spleen enlargement, according to Medline Plus.

Metabolic Acidosis

Metabolic acidosis -- a condition that develops when your body produces too much acid -- may occur as a symptom of low glutathione levels. High acid levels may induce breathing problems, severe fatigue and confusion. If the amount of acid in your blood remains persistently high, your child may develop life-threatening medical complications such as shock.

Seizures or Poor Coordination

Neurological complications, such as seizures or poor motor coordination, may occur in children with glutathione synthase deficiency, the Illinois Department of Public Health says. Seizures may result in unusual muscle spasms, twitching or loss of consciousness. Your child may also have difficulty performing normal motor activities, such as crawling or walking, due to depleted glutathione levels.

Speech or Intellectual Disabilities

Speech or intellectual disability may arise as symptoms of glutathione depletion. Your child may have difficulty speaking clearly or may speak more slowly than other children in his age group. Intellectual disabilities may make it challenging for your child to learn age-appropriate educational material. These symptoms may have a significant impact on your child's ability to meet normal developmental milestones.

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