What Is Plus 4 in Glucose Levels?

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Physicians measure glucose, a carbohydrate used by your body for energy generation, in the urine. Any value above plus zero glucose in the urine can indicate abnormality and may be a red flag for a serious medical condition -- diabetes mellitus. Diabetes can cause serious damage to your circulation, leading to multiple-organ-system compromise over time. Doctors treat diabetes with dietary changes, exercise and medications.

What is Glucose?

Glucose fuels your body and brain. Most of the carbohydrates you consume as part of your daily diet converts to glucose via a set of biochemical reactions that begin in your mouth, continue in your intestines and finish after the ingested carbohydrates have been transported into your blood stream.

How is Glucose Measured?

Depending on the reason you are having your glucose measured, your doctor may want a glucose measurement from your blood, from your urine or from your cerebrospinal fluid. As well, depending on the type of test you're going to have, you may be requested to fast for at least 8 hours prior to the test. Urine glucose measurements are typically reported in positive-integer increments, and a typical urine glucose measurement is plus zero, since your kidney typically does not excrete any glucose into your urine. A plus four urine glucose reading would indicate that you have an extremely high concentration of glucose in your urine and would mandate further evaluation for diabetes and possibly diabetic ketoacidosis.

Diseases with High Urine Glucose

In the vast majority of cases, high urine glucose known as "glycosuria," results from hyperglycemia occurring with diabetes mellitus. However, there are some genetic disorders that result in glycosuria. For example, Fanconi's syndrome, a genetic disorder that causes the kidney to poorly reabsorb several substances, results in glycosuria. Glycosuria can occur during pregnancy, with most women experiencing a return to normal urine glucose levels after giving birth.

Health Consequences of High Glucose

Atypically high blood glucose, also known as diabetes mellitus, leads to pathologic changes in your circulatory system that can cause serious damage to your heart, kidneys, nerves and eyes. This occurs because the excess glucose in your blood attaches itself to proteins found in these organs, irreversibly altering their function.


If you have significant glycosuria as the result of diabetes, your doctor may ask you to try lifestyle modifications to bring down your blood glucose. These include eating a healthier diet and exercising regularly. If these measures fail to adequately lower your blood glucose, your doctor may prescribe medications such as metformin or insulin, designed to lower blood glucose.