Food Sources of Methionine and Cysteine
When protein is in food the food, your digestive system breaks it down into amino acids, and your body uses these to manufacture hundreds of new proteins needed by all your cells. Two amino acids, called cysteine and methionine, are unusual because they contain the element sulfur, which plays an important role in determining the shape of new proteins by helping these compounds fold. Many common foods are good sources of both these amino acids.
Meat and Poultry
Animal-based foods are generally good sources of both methionine and cysteine 2. For example, a serving of lean beef loin that weighs about 6 ounces provides 1,270 milligrams of methionine and 470 milligrams of cysteine, while a similar-sized serving of a pork chop that's trimmed of fat contains about 1,145 milligrams of methionine and 460 milligrams of cysteine. Other meats such as lamb and game meats are also good sources. Poultry is also rich in both amino acids, with 1 cup of roasted and chopped chicken breast meat providing about 1,200 milligrams of methionine and 550 milligrams of cysteine.
- Animal-based foods are generally good sources of both methionine and cysteine 2.
- Poultry is also rich in both amino acids, with 1 cup of roasted and chopped chicken breast meat providing about 1,200 milligrams of methionine and 550 milligrams of cysteine.
Fish and Seafood
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Most fish and certain types of seafood are also good sources of methionine and cysteine. Other common types of fish, such as:
- herring
- trout
- haddock
- bluefish
- are also good sources of both amino acids
Eggs and Dairy Products
Dairy products are also good sources of both amino acids 4. Other cheeses, such as cheddar, Parmesan and mozzarella, are also rich in both compounds. Milk provides both amino acids in slightly lesser amounts. For example, 1 cup of nonfat milk provides about 200 milligrams of methionine and 50 milligrams of cysteine. Eggs are also a good source, with about 190 milligrams of methionine and 135 milligrams of cysteine in 1 large cooked egg.
- Dairy products are also good sources of both amino acids 4.
- Eggs are also a good source, with about 190 milligrams of methionine and 135 milligrams of cysteine in 1 large cooked egg.
Plant-Based Sources
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If you follow a vegetarian diet, some types of plant-based foods are also good sources of methionine and cysteine. Many types of nuts provide these nutrients, including Brazil nuts, which have about 65 milligrams of methionine and 245 milligrams of cysteine in 1/2 cup.
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References
- University of Maryland Medical Center: Cysteine
- National Nutrient Database: Methionine, Cystine, All Foods
- National Nutrient Database: Methionine, Cystine, Finfish and Shellfish Products
- National Nutrient Database: Methionine, Cystine, Dairy and Egg Products
- National Center for Biotechnology Information. PubChem Database. Methionine. Updated September 21, 2019.
- Park BK, Dear JW, Antoine DJ. Paracetamol (acetaminophen) poisoning. BMJ Clin Evid. 2015;2015:2101. Published 2015 Oct 19.
- Cavuoto P, Fenech MF. A review of methionine dependency and the role of methionine restriction in cancer growth control and lifespan extension. Cancer Treat Rev. 2012;38(6):726-36. doi:10.1016/j.ctrv.2012.01.004
- Tapia-rojas C, Lindsay CB, Montecinos-oliva C, et al. Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener. 2015;10:62. doi:10.1186/s13024-015-0057-0
- Brustolin S, Giugliani R, Félix TM. Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res. 2010;43(1):1-7.
- Cottington EM, LaMantia C, Stabler SP, Allen RH, Tangerman A, Wagner C, Zeisel SH, Mudd SH. Adverse event associated with methionine loading test: a case report. Arteriosclerosis, thrombosis, and vascular biology. 2002 Jun 1;22(6):1046-50. doi:10.1161/01.ATV.0000020400.25088.A7
- ME, Han B, . Are we getting enough sulfur in our diet?. Nutr Metab (Lond). 2007;4:24. doi:10.1186/1743-7075-4-24
- Benevenga NJ, Steele RD. Adverse effects of excessive consumption of amino acids. Annual review of nutrition. 1984 Jul;4(1):157-81. doi:10.1146/annurev.nu.04.070184.001105
- Brok J, Buckley N, Gluud C. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database of Systematic Reviews. 2006, Issue 2. Art. No.: CD003328. doi:10.1002/14651858.CD003328.pub2
- Benevenga NJ, Steele RD. Adverse effects of excessive consumption of amino acids. Annu Rev Nutr. 1984;4:157-8110. doi10.1146/04.070184.001105
- Garlick PJ. Toxicity of methionine in humans. J Nutr. 2006;136(6 Suppl):1722S-1725S. doi:10.1093/jn/136.6.1722S
- Jeon H, Kim JH, Lee E, et al. Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo. Oncotarget. 2016;7(41):67223-67234. doi:10.18632/oncotarget.11615
- Zhou ZY, Wan XY, Cao JW. Dietary methionine intake and risk of incident colorectal cancer: a meta-analysis of 8 prospective studies involving 431,029 participants. PLoS ONE. 2013;8(12):e83588. doi:10.1371/journal.pone.0083588
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Joanne Marie began writing professionally in 1981. Her work has appeared in health, medical and scientific publications such as Endocrinology and Journal of Cell Biology. She has also published in hobbyist offerings such as The Hobstarand The Bagpiper. Marie is a certified master gardener and has a Ph.D. in anatomy from Temple University School of Medicine.