What does fact checked mean?
At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
Side Effects of Not Tapering Off of Sertraline
Sertraline, or Zoloft, is a prescription drug used for the treatment of major depression 3. Other indications include obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder and social anxiety disorder. Sertraline belongs to a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs 3. The medication must be tapered off once therapy is complete. This means that the dose must be gradually lowered over time to avoid side effects.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Flu-Like Symptoms
Flu-like symptoms are common in patients who stop sertraline abruptly 3. Flu-like symptoms include headache, muscle ache, chills, fatigue and fever. According to the American Academy of Family Physicians, discontinuation symptoms are mild and may last one to two weeks 1. Symptoms associated with not tapering off sertraline are described as discontinuation syndrome and is more likely to occur with a longer duration of treatment 3.
Dysphoria
Symptoms When Stopping Lexapro
Learn More
Abrupt discontinuation of sertraline may lead to dysphoria, which is characterized by sadness, anxiety, irritability and restlessness 3. The “Drug Information Handbook” explains that if the patient develops intolerable symptoms following a decrease in the dose or stopping therapy, the previous dose should be given and a more gradual dose should be considered.
Sensory Disturbances and Imbalance
Sensory disturbances, such as tingling and numbness, may appear in patients who stop sertraline 3. Patients may also experience imbalance and should use caution when moving to standing position. Confusion may also be seen in individuals. Patients must not discontinue the medication without speaking with a physician first.
- Sensory disturbances, such as tingling and numbness, may appear in patients who stop sertraline 3.
- Patients may also experience imbalance and should use caution when moving to standing position.
Insomnia
Bad Side Effects From Wellbutrin
Learn More
Insomnia, or trouble sleeping, is another side effect of not tapering off sertraline, reports MayoClinic.com 3. This may lead to fatigue and dizziness, which have also been reported in patients. If a patient’s symptoms are severe, he should contact a physician. Usually administering a dose of the drug will cause side effects to cease.
- Insomnia, or trouble sleeping, is another side effect of not tapering off sertraline, reports MayoClinic.com 3.
- This may lead to fatigue and dizziness, which have also been reported in patients.
Sweating and Tremor
Patients may develop increased sweating when going through sertraline tapering 3. Tremor or shaking may occur as well. The AAFP states that discontinuation side effects are more likely to occur in individuals who have been taking sertraline for at least six weeks 3.
Headache and Nausea
Headache is a common symptom that may occur in individuals discontinuing an SSRI such as sertraline 3. Gastrointestinal side effects include nausea, vomiting and diarrhea. Patients should be counseled on the effects of suddenly stopping the medication, because if they develop discontinuation side effects, they will be aware of the reason and be able to communicate this to a physician. This will avoid unnecessary examinations and misdiagnosis.
- Headache is a common symptom that may occur in individuals discontinuing an SSRI such as sertraline 3.
Related Articles
References
- American Academy of Family Physicians: Antidepressant Discontinuation Syndrome
- "Drug Information Handbook"; Charles F. Lacy, Lora L. Armstrong, et al.; 2009
- Mayo Clinic: Sertraline
- National Association of Mental Illness. Sertraline (Zoloft). December 2018.
- Davies J, Read J. A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? Addict Behav. 2019;97:111-121. doi:10.1016/j.addbeh.2018.08.027
- Glenmullen J. The Antidepressant Solution: A Step-by-Step Guide to Safely Overcoming Antidepressant Withdrawal, Dependence, and “Addiction.” New York, NY: Free Press; 2005.
- Fava GA, Gatti A, Belaise C, Guidi J, Offidani E. Withdrawal symptoms after selective serotonin reuptake inhibitor discontinuation: a systematic review. Psychother Psychosom. 2015;84(2):72-81. doi:10.1159/000370338
- Horowitz MA, Taylor D. Tapering of SSRI treatment to mitigate withdrawal symptoms. Lancet Psychiatry. 2019 Jun;6(6):538-546. doi:10.1016/S2215-0366(19)30032-X
- Burcusa SL, Iacono WG. Risk for recurrence in depression. Clin Psychol Rev. 2007;27(8):959–985. doi:10.1016/j.cpr.2007.02.005
- Harvard Health Publishing. Going off antidepressants. Updated 2018.
Resources
Writer Bio
Karla Casco began writing in 2010, focusing her work on diseases and treatments and their side effects. She has also created patient handouts, PowerPoint presentations and journal clubs. Karla has a doctorate in pharmacy from St. John's University and holds a pharmacy license for the state of New York.