What does fact checked mean?
At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
How do I Take Bromelain?
Bromelain is a group of protein-digesting enzymes obtained from the fruit and stem of pineapple. These enzymes are useful for treating a wide range of health conditions, according to the University of Maryland Medical Center 1. As an herbal remedy, bromelain is available in tablets and capsules, and it also can be applied topically. Consult with a qualified health care provider before beginning any herbal therapy.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Benefits
Bromelain is particularly beneficial for decreasing inflammation, explains the UMMC. Commission E, the German regulatory agency for herbs, has approved bromelain to treat swelling and inflammation following surgery. These enzymes also may reduce healing time, swelling and pain caused by injuries, including sprains and muscle strains. Bromelain may relieve the pain of osteoarthritis and rheumatoid arthritis. In addition, bromelain may decrease symptoms of sinusitis and hay fever. As a group of protein-digesting enzymes, bromelain may relieve upset stomach and heartburn. Topically, it can decrease swelling from insect stings and bites and help remove damaged tissue from severe burns.
- Bromelain is particularly beneficial for decreasing inflammation, explains the UMMC.
- Topically, it can decrease swelling from insect stings and bites and help remove damaged tissue from severe burns.
General Guidelines
Side Effects of Bioflavonoid Quercetin & Bromelain
Learn More
Because you may experience side effects from bromelain supplements, and because bromelain interacts with some medications, the UMMC recommends taking bromelain only with the supervision of a qualified health care provider. It's best not to give bromelain to children, because pediatric research is lacking on this supplement. You generally should not take bromelain for longer than 10 days consecutively.
Dosage
Commission E recommends taking 80 to 320 mg of bromelain two or three times per day, according to MedlinePlus. In contrast, some herbalists recommend taking 500 to 1,000 mg three times daily. The UMMC notes standard doses for specific conditions include 500 mg per day in divided doses for digestive issues, 500 mg four times per day for injuries and 500 to 2,000 mg per day in two divided doses for arthritis. For digestive problems, take the supplement with meals, and otherwise, take it on an empty stomach. You might consider starting with a low dose and increasing the amount if necessary.
- Commission E recommends taking 80 to 320 mg of bromelain two or three times per day, according to MedlinePlus.
- In contrast, some herbalists recommend taking 500 to 1,000 mg three times daily.
Topical Bromelain
Borage Oil Side Effects
Learn More
Bromelain also is available in topical creams. Some health care providers clean wounds and treat severe burns with these topical preparations. The UMMC cautions people not to attempt treating severe burns without professional medical attention.
Drug Interactions
Bromelain interacts with numerous drugs, as noted by MedlinePlus, so you might not want to take bromelain if you are using these medications. The substance can increase the risk of bleeding when taken with drugs that have blood-thinning effects, such as:
- warfarin
- heparin
- clopidogrel
- ibuprofen
- aspirin
Bromelain may increase absorption of some antibiotics, particularly amoxicillin and tetracycline, which can increase side effects of these drugs. Bromelain also may increase the effects of some sedatives, high blood pressure drugs and chemotherapy medications.
Related Articles
References
- University of Maryland Medical Center: Bromelain
- Ameye LG, Chee WS. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther. 2006;8(4): R127.
- Baez R, Lopes MT, Salas CE, Hernandez M. In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain. Planta Med. 2007 Oct;73(13):1377-83.
- Braun JM, Schneider B, Beuth HJ. Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany. In Vivo. 2005;19:417–421.
- Brien S, Lewith G, Walker A, Hicks SM, Middleton D. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257.
- Brien S1, Lewith G, Walker AF, Middleton R, Prescott P, Bundy R. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM. 2006 Dec;99(12):841-50.
- Buttner L, et al. Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis—a pilot study. B-ENT. 2013;9(3):217-25.
- Chobotova K1, Vernallis AB, Majid FA. Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives. Cancer Lett. 2010 Apr 28;290(2):148-56.
- Dhandayuthapani S1, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A. Bromelain-induced apoptosis in GI-101A breast cancer cells. J Med Food. 2012 Apr;15(4):344-9.
- Guo R, Canter PH, Ernst E. Herbal medicines for the treatment of rhinosinusitis: a systematic review. Otolaryngol Head Neck Surg. 2006 Oct;135(4):496-506.
- Hale LP1, Greer PK, Trinh CT, Gottfried MR. Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease. Clin Immunol. 2005 Aug;116(2):135-42.
- Memorial Sloan Kettering Cancer Center. Bromelain.
- National Center for Complementary and Integrative Health. Bromelain.
- Onken JE, Greer PK, Calingart B, Hale LP. Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro. Clin Immunol. 2008 Mar;126(3):345-52. Epub 2007 Dec 21.
- Pavan R1, Jain S, Shraddha, Kumar A. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203.
- Rathnavelu Vidhya, et al. Potential role of bromelain in clinical and therapeutic applications. Biomed Rep. 2016 Sep; 5(3): 283–288.
- Rosenberg L, Shoham Y, Krieger Y, et al. Minimally invasive burn care: a review of seven clinical studies of rapid and selective debridement using a bromelain-based debriding enzyme (Nexobrid). Ann Burns Fire Disasters. 2015 Dec 31;28(4):264-274.
- Ryan RE. A double-blind clinical evaluation of bromelains in the treatment of acute sinusitis. Headache. 1967;7:13-17.
- Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma. Altern Ther Health Med. 2012 Sep-Oct;18(5):9-17.
- Tejpal Singh, Vinayak More, Umayra Fatima, Tanveer Karpe, Mohammed A. Aleem, J. Prameela. Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars. J Int Soc Prev Community Dent. 2016 Dec; 6(Suppl 3): S197–S204.
- Walker AF1, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine. 2002 Dec;9(8):681-6.
Writer Bio
Shelley Moore is a journalist and award-winning short-story writer. She specializes in writing about personal development, health, careers and personal finance. Moore has been published in "Family Circle" magazine and the "Milwaukee Sentinel" newspaper, along with numerous other national and regional magazines, daily and weekly newspapers and corporate publications. She has a Bachelor of Science in psychology.