Side Effects of Tylenol 3 With Codeine

Tylenol 3 with codeine is a prescription medication used to relieve moderate to severe pain 1. Although the medication can be effective at reducing or eliminating pain, it also may produce undesirable side effects for some people. Individuals should discuss their questions and concerns about the side effects of Tylenol 3 with codeine with a doctor 14.

Is This an Emergency?

If you are experiencing serious medical symptoms, seek emergency treatment immediately.

Side Effects

Serious side effects are less common, but may include:

  • nausea
  • appetite loss
  • stomach pain
  • itching
  • dark urine
  • clay-colored stools
  • jaundice
  • easy bruising or bleeding
  • seizures
  • confusion
  • unusual thoughts or behavior
  • shallow breathing
  • slow heartbeat
  • according to

Individuals experiencing any of these serious side effects should seek immediate medical attention.

Allergic Reaction

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Some people may experience an allergic reaction to Tylenol 3 with codeine 1. Signs of an allergic reaction may include hives, difficulty breathing or swelling of the lips, face, throat or tongue. Those experiencing this reaction should call a doctor or 911 immediately.


Accidentally or intentionally taking more than the recommended amount of this medication may result in an acetaminophen and codeine overdose 234. Symptoms of an overdose may include:

  • kidney failure
  • liver failure
  • vomiting
  • stomach or intestinal spasms
  • nausea
  • heavy sweating
  • clammy skin
  • bluish skin
  • stupor
  • drowsiness
  • convulsions
  • coma
  • low blood pressure
  • pinpoint pupils
  • respiratory arrest
  • slow or labored breathing or shallow breathing
  • according to MedlinePlus [2]( 'inline-reference::MedlinePlus: Acetaminophen
  • Codeine Overdose')

Individuals experiencing an overdose need emergency medical attention.

Drug Interactions

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Certain medications may interact with Tylenol 3 with codeine and alter or intensify side effects 14. Drugs known to interact with Tylenol 3 with codeine include:

  • irritable bowel medications
  • bronchodilators
  • bladder or urinary medications
  • atropine
  • benztropine
  • dimenhydrinate
  • ethscopolamine
  • scopolamine
  • mepenozoalte
  • glycopyrrolate
  • according to 1

Medications that cause

  • drowsiness may also increase the drowsiness side effect of the codeine in Tylenol 3
  • including cold or allergy medications
  • sedatives
  • sleeping pills
  • muscle relaxers
  • antidepressants
  • anti-anxiety medications
  • seizure medications
  • other pain relievers 1


Individuals should always call a doctor if they are concerned about a side effect they are experiencing while taking Tylenol 3 with codeine 1. A physician may be able to offer suggestions of how to reduce or prevent certain side effects from occurring, explains 4. People may also consider reporting side effects to the U.S. Food and Drug Administration by calling (800) FDA-1088.